Nanoferulic: From a by-product of the beer industry toward the regeneration of the skin
Open accessAbstract
BACKGROUND: Brewers' spent grain (BSG) is one of the most abundant by-products of the beer industry and causes serious environmental problems. Ferulic acid (FA) is an antioxidant with potential cosmeceutical applications. FA was extracted from BSG, developing a method of high extraction performance in order to be encapsulated in ultradeformable liposomes (Nanoferulic, NF). AIMS: To obtain a product with high added value such as FA, from a residue currently underused, using simple and economical chemical methods. To load FA into a nanosystem designed for the topical route, its encapsulation has the purpose to take profit from its photoprotective, anti-inflammatory, and antioxidant properties in the deep layers of the skin. METHODS: Ferulic acid was obtained from dried BSG using acid and basic treatments in series. NF was prepared by lipid film resuspension of a solution containing FA obtained from BSG. Size and Z-potential were determined. Cytotoxicity was assessed in vitro. Skin penetration was assessed by NF determination at different skin depths and by confocal microscopy. RESULTS: The yield of the extraction process was 0.43% on a dry basis. Encapsulation rendered liposomes of around 140 nm with 92% of encapsulation efficiency. No toxicity was observed in all the tested concentrations. Successful results were obtained from the regeneration studies. CONCLUSIONS: It was possible to develop a nanosystem containing FA, generating a high-value commercial input for the pharmaceutical and cosmeceutical industry. The use of BSG generated in industrial scale would help to reduce the volume of highly polluting waste.
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Regeneration studies have shown a significant improvement in skin condition during application of a liposomal nanosystem containing ferulic acid.
“Moreover, the regeneration studies have shown a significant improvement in skin condition during application of a liposomal nanosystem containing ferulic acid.”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [93]
Ferulic acid does not exhibit toxicity even at higher concentrations.
“It has been proved that ferulic acid does not exhibit toxicity even at higher concentrations.”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [93]
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“In the non-edible parts of fruits (peels or twigs), the content of bioactive compounds, such as polyphenols, is often higher than in the edible parts (pulp) [65,73].”
- Authors
- Bucci, P. L., Santos, M. V., Montanari, J., & Zaritzky, N.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National University of Quilmes (AR)
- Centro de Investigación y Desarrollo en Criotecnología de los Alimentos (CONICET, Facultad de Ciencias Exactas UNLP, CIC.PBA, Argentina) Universidad Nacional de la Plata La Plata Argentina
- Corresponding author
- Bucci, Paula Lorena
- Venue
- Journal of Cosmetic Dermatology
- Publisher
- Wiley
- Published
- 2020-04-19
- Volume
- 19
- Issue
- 11
- Pages
- 2958-2964
- ISSN
- 1473-2130 (ISSN-L)
- 1473-2165
- OpenAlex
- W3016709289
- Cited by
- 18
- References
- 25
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 6 · 2023: 4 · 2021: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Cosmetic Dermatology (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- ferulic acid, brewer's spent grain, brewing by-products, transfersomes, liposome encapsulation, skin regeneration, antioxidants, photoprotection, anti-inflammatory agents, cosmeceuticals, waste valorization, encapsulation efficiency
- MeSH terms
- Antioxidants, Beer, Edible Grain, Humans, Regeneration
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