A serum containing vitamins C & E and a matrix‐repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto‐perception
Open accessAbstract
Background: Allegations on the benefits of incorporating vitamin C, vitamin E, and combinations thereof in topical skincare formulations are mostly based on in vitro and ex vivo experiments and/or limited protocols of specific stress conditions (pollution, UV exposure, laser irradiation,…). Objective: To evaluate the instrumentally measurable effects and quantitative consumer perceptions of a protective and reparative serum on a panel of volunteers under normal nonstressed conditions of use, employing FOITS technology and innovative self‐assessment methods. Method: In an open‐label study women of ≥40 years with visible signs of photoaging applied a serum comprising l‐ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide‐38 to the face once daily for 56 days. Skin roughness and isotropy changes were evaluated on days 0, 28, and 56, visual instrumental evaluation of skin‐tone parameters was assessed on days 0 and 56. Subjects completed self‐assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance. Results: Skin‐roughness parameters decreased significantly by 8%‐9% (P < .05) and subjects experienced a significant increase in skin isotropy (P < .05). Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles. Conclusion: The study confirms statistically significant correlation between objectively measured and quantitative subjectively perceived benefits of the bespoke serum containing antioxidants and a matrix‐restoring peptide.
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Combining topical vitamins C and E has been shown to significantly improve signs of aging, including skin smoothing, brightening of the skin tone, and wrinkle reduction.
“Combining topical vitamins C and E has also been shown to significantly improve signs of aging, including skin smoothing, brightening of the skin tone, and wrinkle reduction.25”
From A Double-Blinded, Split-Face Clinical Trial Evaluating the Effects of a Vitamin C, E, and Ferulic Acid Serum Combined with Microneedling on Facial Photoaging (2026) · cites this paper as [25]
The Conclusion reports significant smoothing, skin-tone brightening, and anti-wrinkle effects from a serum containing vitamins C and E plus a matrix-restoring peptide. The Discussion says the study did not test the ingredients separately, so it cannot establish that combining the two vitamins produced those improvements. (LLM, conf=0.90)
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Cites
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Cited by
Sorted by citations
Liu, C., Boo, J., Kim, H., Hwang, S., Yan, X., Brieva, P., Kim, J., & Kim, J. (2026) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s565035 · Cited by 1 · see citing works
- Authors
- Lintner, K., Gerstein, F., & Solish, N.
- Affiliations
- KAL'IDEES S.A.S. Paris France
- True MediSpa Toronto ON Canada
- University of Toronto (CA)
- Corresponding author
- Lintner, Karl
- Venue
- Journal of Cosmetic Dermatology
- Publisher
- Wiley
- Published
- 2020-10-26
- Volume
- 19
- Issue
- 12
- Pages
- 3262-3269
- ISSN
- 1473-2130 (ISSN-L)
- 1473-2165
- PMC
- PMC7756752
- OpenAlex
- W3093794730
- Cited by
- 19
- References
- 4
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Cosmetic Dermatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- photoaging, facial aging, serum, vitamin C, vitamin E, skin roughness, skin tone, skin redness, self-perception, antioxidants, women over 40
- MeSH terms
- Aging, Face, Female, Humans, Perception, Vitamins, Skin Aging
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