Topical Peptide Treatments with Effective Anti-Aging Results
Open accessAbstract
In the last two decades, many new peptides have been developed, and new knowledge on how peptides improve the skin has been uncovered. The spectrum of peptides in the field of cosmetics is continuously growing. This review summarizes some of the effective data on cosmeceutical peptides that work against intrinsic and extrinsic aging. Some peptides have been proven in their efficacy through clinical skin trials. Well-known and documented peptides like copper tripeptide are still under research to obtain more details on their effectiveness, and for the development of new treatments. Palmitoyl pentapeptide-4 and Carnosine are other well-researched cosmeceuticals. Additionally, there are many more peptides that are used in cosmetics. However, study results for some are sparse, or have not been published in scientific journals. This article summarizes topical peptides with proven efficacy in controlled in vivo studies.
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Schagen's article lacks clinical trials to support claims of anti-aging results from peptide treatments.
“Furthermore, there is a lack of clinical trials mentioned in the article to support the claims of anti‐aging results from peptide treatments.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [51]
The Introduction says the article summarizes clinical studies confirming peptide efficacy on human skin, and the Conclusions discuss clinical in vivo trials. Schagen identifies limitations in some studies, including formulations with other active ingredients and small participant numbers, but does not say the article lacks clinical trials. (LLM, conf=0.90)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredSchagen's article on topical peptide treatments has low level of evidence because it primarily relies on anecdotal evidence and in vitro studies.
“However, the level of evidence provided in this article is low, as the author primarily relies on anecdotal evidence and in vitro studies.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [51]
The Introduction says the article summarizes clinical studies on human skin, and §2.7 describes double-blind, placebo-controlled trials—not primarily anecdotal or in vitro evidence. The Conclusions acknowledge limitations in some clinical studies, including small samples and formulations with other active ingredients, but do not support the stated reason for calling the article’s evidence low. Page numbers were not available in our copy. (LLM, conf=0.87)
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“The article by Schagen 51 titled “Topical peptide treatments with effective anti-aging results” provides a comprehensive review of the use of peptides in skincare products.”
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- Authors
- Schagen, S.
- Affiliations
- Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (FR)
- Corresponding author
- Schagen, Silke
- Venue
- Cosmetics
- Publisher
- MDPI AG
- Published
- 2017-05-22
- Volume
- 4
- Issue
- 2
- Pages
- 16
- ISSN
- 2079-9284 (ISSN-L)
- OpenAlex
- W2617896390
- Cited by
- 195
- References
- 49
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 21 · 2023: 18 · 2022: 25 · 2021: 19 · 2020: 20 · 2019: 14 · 2018: 9 · 2017: 2
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cosmetics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- cosmeceuticals, skin aging, anti-aging, intrinsic aging, extrinsic aging, carnosine, in vivo efficacy
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