The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Inflammation and plaque vulnerability
Open accessAbstract
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers the formation of a thrombus. By occluding the lumen, the thrombus or emboli detaching from it elicits ischaemic symptoms that may be life‐threatening. Two types of surface damage can cause atherothrombosis: plaque rupture and endothelial erosion. Plaque rupture is thought to be caused by loss of mechanical stability, often due to reduced tensile strength of the collagen cap surrounding the plaque. Therefore, plaques with reduced collagen content are thought to be more vulnerable than those with a thick collagen cap. Endothelial erosion, on the other hand, may occur after injurious insults to the endothelium instigated by metabolic disturbance or immune insults. This review discusses the molecular mechanisms involved in plaque vulnerability and the development of atherothrombosis.
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Cites
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Self-citationMechanisms of plaque formation and rupture
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Cited by
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Self-citationNeutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Efferocytosis in health and disease
Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066
Self-citationResearch Progress on the Relationship between Atherosclerosis and Inflammation
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Gao, C., Huang, Q., Liu, C., Kwong, C. H. T., Yue, L., Wan, J.-B., Lee, S. M. Y., & Wang, R. (2020) · Nature Communications · doi:10.1038/s41467-020-16439-7 · Cited by 630
Metadata
- Authors
- Hansson, G. K., Libby, P., & Tabas, I.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2015-08-11
- Volume
- 278
- Issue
- 5
- Pages
- 483-493
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2150795824
- Cited by
- 805
- References
- 13
- FWCI
- 27.21
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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