Efferocytosis in health and disease

Doran, Amanda C.; Yurdagul, Arif; Tabas, Ira

doi:10.1038/s41577-019-0240-6

Cited by 1,066Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

Efferocytosis in health and disease

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Doran, Amanda C., Yurdagul, Arif, Tabas, Ira·2020·Nature Reviews Immunology

DOI 10.1038/s41577-019-0240-6PMC PMC7667664

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Abstract

The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and uptake, several key areas remain incompletely understood. This Review focuses on new discoveries related to how phagocytes process the metabolic cargo they receive during apoptotic cell uptake; the links between efferocytosis and the resolution of inflammation in health and disease; and the roles of efferocytosis in host defence. Understanding these aspects of efferocytosis sheds light on key physiological and pathophysiological processes and suggests novel therapeutic strategies for diseases driven by defective efferocytosis and impaired inflammation resolution.

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Efferocytosis in other settings can promote fibrosis as part of tissue resolution, for example, by secreting TGF-β1.
“efferocytosis in other settings can promote fibrosis as part of the tissue resolution process, for example, by secreting TGF-β1 (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [12]
The Conclusions (page unavailable) say a fibrotic response can follow efferocytosis. In “Myocardial infarction and heart failure” (page unavailable), the review says efferocytic myofibroblasts upregulate Tgfb and that their TGFβ production may promote excessive fibrosis. It does not establish secretion of TGF-β1 specifically or characterize that fibrosis as part of tissue resolution; it cautions that the fibrosis may be harmful. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Accumulation of dead cells in disease indicates impaired clearance by macrophages.
“The accumulation of dead cells in disease settings indicates impaired clearance of dead cells by macrophages (“efferocytosis”) (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [12]
Efferocytosis prevents dead cell accumulation and reprograms macrophages for tissue resolution, and its impairment contributes to many chronic inflammatory diseases.
“Efferocytosis not only prevents dead cell accumulation but also reprograms macrophages to execute tissue resolution functions, and impaired efferocytosis contributes to many human chronic inflammatory diseases (12, 13).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [12]
Efferocytosis can reprogram macrophages toward a proresolving, disease-suppressing state.
“Efferocytosis can reprogram macrophages to a proresolving, disease-suppressing state (12, 39)”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [12]

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Authors: Doran, A. C., Yurdagul, A., & Tabas, I.
Affiliations: Vanderbilt University (US)
Columbia University Irving Medical Center (US)
Corresponding author: Tabas, Ira
ORCID: Doran, Amanda C.
Yurdagul, Arif
Tabas, Ira
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2019-12-10
Volume: 20
Issue: 4
Pages: 254-267
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-019-0240-6
PMC: PMC7667664
OpenAlex: W2995149669
Cited by: 1,066
References: 163
Citations by year: 2026: 208 · 2025: 240 · 2024: 184 · 2023: 174 · 2022: 125 · 2021: 93 · 2020: 42
FWCI: 5.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (K99HL145131, R01HL127464, P01HL087123, R35HL145228)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: efferocytosis, phagocytes, tissue homeostasis, inflammation resolution, chronic inflammatory diseases, apoptotic cell recognition, host defense, treatment options
MeSH terms: Homeostasis, Humans, Inflammation, Phagocytes, Phagocytosis, Apoptosis

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