The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Diagnosis and treatment of primary aldosteronism: practical clinical perspectives
Abstract
Primary aldosteronism (PA), the most common form of secondary hypertension, can be either surgically cured or treated with targeted pharmacotherapy. PA is frequently undiagnosed and untreated, leading to aldosterone‐specific cardiovascular morbidity and nephrotoxicity. Thus, clinicians should perform case detection testing for PA at least once in all patients with hypertension. Confirmatory testing is indicated in most patients with positive case detection testing results. The next step is to determine whether patients with confirmed PA have a disease that can be cured with surgery or whether it should be treated medically; this step is guided by computed tomography scan of the adrenal glands and adrenal venous sampling. With appropriate surgical expertise, laparoscopic unilateral adrenalectomy is safe, efficient and curative in patients with unilateral adrenal disease. In patients who have bilateral aldosterone hypersecretion, the optimal management is a low‐sodium diet and lifelong treatment with a mineralocorticoid receptor antagonist administered at a dosage to maintain a high–normal serum potassium concentration without the aid of oral potassium supplements.
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Funder, J. W., Carey, R. M., Mantero, F., Murad, M. H., Reincke, M., Shibata, H., Stowasser, M., & Young, W. F. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4061 · Cited by 2,925
Self-citationFunder, J. W., Carey, R. M., Fardella, C., Gomez-Sanchez, C. E., Mantero, F., Stowasser, M., Young, W. F., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0104 · Cited by 1,554
Self-citationEvidence for an increased rate of cardiovascular events in patients with primary aldosteronism
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A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients
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K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
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Williams, T. A., Lenders, J. W. M., Mulatero, P., Burrello, J., Rottenkolber, M., Adolf, C., Satoh, F., Amar, L., Quinkler, M., Deinum, J., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30135-3 · Cited by 969
Self-citationMulatero (2004) · doi:10.1210/jc.2003-031337 · Cited by 961
Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome.
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Cited by
Primary Aldosteronism: Cardiovascular Outcomes Pre- and Post-treatment
Hundemer, G. L. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1185-x · Cited by 27
Metadata
- Authors
- Young, W. F.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2018-09-25
- Volume
- 285
- Issue
- 2
- Pages
- 126-148
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2893337330
- Cited by
- 325
- References
- 189
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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