Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis
Abstract
Background There is conflicting evidence, relying on heterogeneous studies, as to whether aldosterone excess is responsible for an increased risk of cardiovascular and cerebrovascular complications in patients with primary aldosteronism. We aimed to assess the association between primary aldosteronism and adverse cardiac and cerebrovascular events, target organ damage, diabetes, and metabolic syndrome, compared with the association of essential hypertension and these cardiovascular and end organ events, by integrating results of previous studies.Methods We did a meta-analysis of prospective and retrospective observational studies that compared patients with primary aldosteronism and essential hypertension, to analyse the association between primary aldosteronism and stroke, coronary artery disease (as co-primary endpoints), atrial fibrillation and heart failure, target organ damage, metabolic syndrome, and diabetes (as secondary endpoints). We searched MEDLINE and Cochrane Library for articles published up to Feb 28, 2017, with no start date restriction. Eligible studies compared patients with primary aldosteronism with patients with essential hypertension (as a control group) and reported on the clinical events or endpoints of interest. We also compared primary aldosteronism subtypes, aldosterone-producing adenoma, and bilateral adrenal hyperplasia.Findings We identified 31 studies including 3838 patients with primary aldosteronism and 9284 patients with essential hypertension. After a median of 8·8 years (IQR 6·2-10·7) from the diagnosis of hypertension, compared with patients with essential hypertension, patients with primary aldosteronism had an increased risk of stroke (odds ratio [OR] 2·58, 95% CI 1·93-3·45), coronary artery disease (1·77, 1·10-2·83), atrial fibrillation (3·52, 2·06-5·99), and heart failure (2·05, 1·11-3·78). These results were consistent for patients with aldosterone-producing adenoma and bilateral adrenal hyperplasia, with no difference between these subgroups. Similarly, primary aldosteronism increased the risk of diabetes (OR 1·33, 95% CI 1·01-1·74), metabolic syndrome (1·53, 1·22-1·91), and left ventricular hypertrophy (2·29, 1·65-3·17).Interpretation Diagnosing primary aldosteronism in the early stages of disease, with early initiation of specific treatment, is important because affected patients display an increased cardiovascular risk compared with patients with essential hypertension.Funding None.
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PA is associated with increased risk of stroke, coronary artery disease, atrial fibrillation, heart failure, and mortality compared with matched essential hypertension.
“PA is associated with an increased risk of stroke (odds ratio [OR] 2.58, 95% CI 1.93-3.45), coronary artery disease (1.77, 1.10-2.83), atrial fibrillation (3.52, 2.06-5.99), heart failure (2.05, 1.11-3.78), and mortality (hazard ratio [HR] 1.34, 95% CI 1.06-1.71) compared with matched populations with essential hypertension (278,279).”
From Adrenal incidentaloma (2020) · cites this paper as [278]
Diabetes/metabolic syndrome, renal damage, impaired bone mineral density, and osteoporosis have been reported more prevalent in AI patients with PA.
“Diabetes mellitus/metabolic syndrome (278,279), renal damage (280), impaired bone mineral density (81), and osteoporosis (264,281,282) have also been reported to be more prevalent in AI patients with PA.”
From Adrenal incidentaloma (2020) · cites this paper as [278]
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826 · see citing works
Funder, J. W., Carey, R. M., Mantero, F., Murad, M. H., Reincke, M., Shibata, H., Stowasser, M., & Young, W. F. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4061 · Cited by 2,925 · see citing works
Funder, J. W., Carey, R. M., Fardella, C., Gomez-Sanchez, C. E., Mantero, F., Stowasser, M., Young, W. F., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0104 · Cited by 1,554 · see citing works
Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
Milliez, P., Girerd, X. J., Plouin, P., Blacher, J., Safar, M. E., & Mourad, J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.015 · Cited by 1,541 · see citing works
A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients
Rossi, G. P., Bernini, G., Caliumi, C., Desideri, G., Fabris, B., Ferri, C., Ganzaroli, C., Giacchetti, G., Letizia, C., Maccario, M., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.059 · Cited by 1,467 · see citing works
Williams, T. A., Lenders, J. W. M., Mulatero, P., Burrello, J., Rottenkolber, M., Adolf, C., Satoh, F., Amar, L., Quinkler, M. O., Deinum, J., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30135-3 · Cited by 977 · see citing works
Self-citationOlsen, M. H., Angell, S. Y., Asma, S., Boutouyrie, P., Burger, D. E., Chirinos, J. A., Damasceno, A. A. M., Delles, C., Gimenez‐Roqueplo, A., Hering, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31134-5 · Cited by 940 · see citing works
Prevalence and Clinical Manifestations of Primary Aldosteronism Encountered in Primary Care Practice
Monticone, S., Burrello, J., Tizzani, D., Bertello, C., Viola, A., Buffolo, F., Gabetti, L., Mengozzi, G., Williams, T. A., Rabbia, F., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.052 · Cited by 888 · see citing works
Self-citationAldosterone induces a vascular inflammatory phenotype in the rat heart
Rocha, R., Rudolph, A. E., Frierdich, G. E., Nachowiak, D. A., Kekec, B. K., Blomme, E. A. G., McMahon, E. G., & Delyani, J. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01096.2001 · Cited by 653 · see citing works
Cardiovascular Outcomes in Patients With Primary Aldosteronism After Treatment
Catena, C. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.33 · Cited by 566 · see citing works
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
Blasi, E., Rocha, R., Rudolph, A. E., Blomme, E. A. G., Polly, M. L., & McMahon, E. G. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00929.x · Cited by 542 · see citing works
Nishikawa, T., Omura, M., Satoh, F., Shibata, H., Takahashi, K., Tamura, N., & Tanabe, A. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0133 · Cited by 535 · see citing works
Savard, S., Amar, L., Plouin, P.-F., & Steichen, O. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01060 · Cited by 505 · see citing works
Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy
Rocha, R., Stier, C. T., Kifor, I., Ochoa-Maya, M. R., Rennke, H. G., Williams, G. H., & Adler, G. K. (2000) · Endocrinology · doi:10.1210/endo.141.10.7711 · Cited by 475 · see citing works
Long-Term Cardio- and Cerebrovascular Events in Patients With Primary Aldosteronism
Mulatero, P., Monticone, S., Bertello, C., Viola, A., Tizzani, D., Iannaccone, A., Crudo, V. L., Burrello, J., Milan, A., Rabbia, F., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2805 · Cited by 413 · see citing works
Self-citationPrevalence and Characteristics of the Metabolic Syndrome in Primary Aldosteronism
Fallo, F., Veglio, F., Bertello, C., Sonino, N., Della Mea, P., Ermani, M., Rabbia, F., Federspil, G., & Mulatero, P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1733 · Cited by 372 · see citing works
Self-citationCatena, C., Colussi, G., Lapenna, R., Nadalini, E., Chiuch, A., Gianfagna, P., & Sechi, L. A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.095448 · Cited by 359 · see citing works
Rossi, G. P., Cesari, M., Cuspidi, C., Maiolino, G., Cicala, M. V., Bisogni, V., Mantero, F., & Pessina, A. C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01316 · Cited by 354 · see citing works
Sowers, J. R., Whaley-Connell, A., & Epstein, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-11-200906020-00005 · Cited by 351 · see citing works
Rocha, R., Martin-Berger, C. L., Yang, P.-C., Scherrer, R., Delyani, J. A., & McMahon, E. L. (2002) · Endocrinology · doi:10.1210/en.2002-220120 · Cited by 308 · see citing works
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism
Arlt, W., Lang, K., Sitch, A. J., Dietz, A. S., Rhayem, Y., Bancos, I., Feuchtinger, A., Chortis, V., Gilligan, L. C., Ludwig, P., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93136 · Cited by 281 · see citing works
Observational Study Mortality in Treated Primary Aldosteronism
Reincke, M., Fischer, E., Gerum, S., Merkle, K., Schulz, S., Pallauf, A., Quinkler, M. O., Hanslik, G., Lang, K., Hahner, S., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.197111 · Cited by 279 · see citing works
Keidar, S., Kaplan, M., Pavlotzky, E., Coleman, R., Hayek, T., Hamoud, S., & Aviram, M. (2004) · Circulation · doi:10.1161/01.cir.0000127949.05756.9d · Cited by 244 · see citing works
Fiebeler, A., Schmidt, F. H., Müller, D. N., Park, J.-K., Dechend, R., Bieringer, M., Shagdarsuren, E., Breu, V., Haller, H. G., & Luft, F. C. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.787 · Cited by 211 · see citing works
Nishizaka, M., Zaman, M. A., Green, S. A., Renfroe, K. Y., & Calhoun, D. A. (2004) · Circulation · doi:10.1161/01.cir.0000129307.26791.8e · Cited by 201 · see citing works
Aldosterone promotes atrial fibrillation
Reil, J., Hohl, M., Selejan, S., Lipp, P., Drautz, F., Kazakow, A., Münz, B., Müller, P., Paul Steendijk, A., Reil, G., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr266 · Cited by 199 · see citing works
Kuster, G. M., Kotlyar, E., Rude, M. K., Siwik, D. A., Liao, R., Colucci, W. S., & Sam, F. (2005) · Circulation · doi:10.1161/01.cir.0000153800.09920.40 · Cited by 194 · see citing works
Guidelines for primary aldosteronism
Mulatero, P., Monticone, S., Burrello, J., Veglio, F., Williams, T. A., & Funder, J. W. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001088 · Cited by 184 · see citing works
Self-citationTanabe, A., Naruse, M., Naruse, K., Mitsuyasu, H. A. S. E., Yoshimoto, T., Tanaka, M., Seki, T., Demura, R., & Demura, H. (1997) · Hypertension Research · doi:10.1291/hypres.20.85 · Cited by 161 · see citing works
Hanslik, G., Wallaschofski, H., Dietz, A., Riester, A., Reincke, M., Allolio, B., Lang, K., Quack, I., Rump, L. C., Willenberg, H. S., et al. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0450 · Cited by 155 · see citing works
Role of Aldosterone in Left Ventricular Hypertrophy in Hypertension
Matsumura, K., FUJII, K., Oniki, H., Oka, M., & Iida, M. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.013 · Cited by 134 · see citing works
Takeda, R., Matsubara, T., Miyamori, I., Hatakeyama, H., & Morise, T. (1995) · Journal of Endocrinological Investigation · doi:10.1007/bf03347840 · Cited by 132 · see citing works
Inappropriate Left Ventricular Mass in Patients With Primary Aldosteronism
Muiesan, M. L., Salvetti, M., Paini, A., Agabiti-Rosei, C., Monteduro, C., Galbassini, G., Belotti, E., Aggiusti, C., Rizzoni, D., Castellano, M., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114140 · Cited by 126 · see citing works
Fasting Plasma Glucose and Serum Lipids in Patients With Primary Aldosteronism
Matrozova, J., Steichen, O., Amar, L., Zacharieva, S., Jeunemaı̂tre, X., & Plouin, P. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.122002 · Cited by 117 · see citing works
Relations between cardiac and vascular structure in patients with primary and secondary hypertension
Rizzoni, D., Muiesan, M. L., Porteri, E., Salvetti, M., Castellano, M., Bettoni, G., Tiberio, G. A. M., Giulini, S. M., Monteduro, C., Garavelli, G., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00322-2 · Cited by 106 · see citing works
Relationships Among Plasma Aldosterone, High-Density Lipoprotein Cholesterol, and Insulin in Humans
Goodfriend, T. L., Egan, B. M., Stepniakowski, K. T., & Ball, D. L. (1995) · Hypertension · doi:10.1161/01.hyp.25.1.30 · Cited by 98 · see citing works
Is Primary Aldosteronism Associated with Diabetes Mellitus? Results of the German Conn's Registry
Reincke, M., Meisinger, C., Holle, R., Quinkler, M. O., Hahner, S., Beuschlein, F., Bidlingmaier, M., Seißler, J., & Endres, S. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0029-1246189 · Cited by 98 · see citing works
A possible association between primary aldosteronism and a lower β-cell function
Mosso, L. M., Carvajal, C. A., Maiz, A., Ortiz, E. H., Castillo, C. R., Artigas, R. A., & Fardella, C. E. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282861fa4 · Cited by 94 · see citing works
Aldosterone excess impairs first phase insulin secretion in primary aldosteronism
Fischer, E., Adolf, C., Pallauf, A., Then, C., Bidlingmaier, M., Beuschlein, F., Seissler, J., & Reincke, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3934 · Cited by 88 · see citing works
Muiesan, M. L., Rizzoni, D., Salvetti, M., Porteri, E., Monteduro, C., Guelfi, D., Castellano, M., Garavelli, G., & Agabiti‐Rosei, E. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00032 · Cited by 88 · see citing works
Pimenta, E., Gordon, R. D., Ahmed, A. H., Cowley, D., Leano, R., Marwick, T. H., & Stowasser, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0354 · Cited by 83 · see citing works
Adipokines and Cardiometabolic Profile in Primary Hyperaldosteronism
Iacobellis, G., Petramala, L., Cotesta, D., Pergolini, M., Zinnamosca, L., Cianci, R., Toma, G. D., Sciomer, S., & Letizia, C. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2204 · Cited by 80 · see citing works
Myocardial Ultrasonic Backscatter in Hypertension
Kozàkovà, M., Buralli, S., Palombo, C., Bernini, G. P., Moretti, A., Favilla, S., Taddei, S., & Salvetti, A. (2003) · Hypertension · doi:10.1161/01.hyp.0000052542.68896.2b · Cited by 76 · see citing works
Primary Aldosteronism and Metabolic Syndrome
Fallo, F., Pilon, C., & Urbanet, R. (2011) · Hormone and Metabolic Research · doi:10.1055/s-0031-1295412 · Cited by 75 · see citing works
The prevalence of metabolic syndrome and its components in two main types of primary aldosteronism
Šomlóová, Z., Widimský, J., Rosa, J., Wichterle, D., Štrauch, B., Petrák, O., Zelinka, T., Vlková, J., Mašek, M., Dvořáková, J., et al. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.65 · Cited by 68 · see citing works
Murata, M., Kitamura, T., Tamada, D., Mukai, K., Kurebayashi, S., Yamamoto, T., Hashimoto, K., Hayashi, R., Kouhara, H., Takeiri, S., et al. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001251 · Cited by 59 · see citing works
Aldosterone target organ protection by eplerenone
Rudolph, A. E., Rocha, R., & McMahon, E. G. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.047 · Cited by 57 · see citing works
Association of plasma aldosterone with the metabolic syndrome in two German populations
Hannemann, A., Meisinger, C., Bidlingmaier, M., Döring, A., Thorand, B., Heier, M., Belcredi, P., Ladwig, K., Wallaschofski, H., Friedrich, N., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1074 · Cited by 57 · see citing works
Chen, W., Li, F., He, C., Zhu, Y., & Tan, W. (2014) · Irish Journal of Medical Science · doi:10.1007/s11845-013-1007-x · Cited by 53 · see citing works
Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Mulatero, P., Milan, A., Williams, T. A., & Veglio, F. (2006) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152506775268776 · Cited by 43 · see citing works
Self-citationRossi, E., Perazzoli, F., Negro, A., & Magnani, A. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001384 · Cited by 42 · see citing works
Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus?
Widimsky, J., Jr., Štrauch, B., Šindelka, G., & Škrha, J. (2001) · Physiological Research · doi:10.33549/physiolres.930123 · Cited by 33 · see citing works
Prejbisz, A., Florczak, E., Klisiewicz, A., Dobrowolski, P., Janaszek-Sitkowska, H., Bieleń, P., Szwench-Pietrasz, E., Warchoł-Celińska, E., Kołodziejczyk-Kruk, S., Janas, J., et al. (2013) · Endokrynologia Polska · doi:10.5603/ep.2013.0019 · Cited by 33 · see citing works
QT interval in patients with primary aldosteronism and low-renin essential hypertension
Maule, S., Mulatero, P., Milan, A., Leotta, G., Caserta, M., Bertello, C., Rabbia, F., & Veglio, F. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000251908.93298.a0 · Cited by 30 · see citing works
Self-citationGoldkorn, R., Yurenev, A. P., Blumenfeld, J. D., Fishman, D., & Devereux, R. B. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02331-7 · Cited by 30 · see citing works
Hung, C., Ho, Y., Chang, Y., et al. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/294594 · Cited by 22 · see citing works
Aldosterone, Sodium, and Hypertension
Funder, J. W. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146936 · Cited by 21 · see citing works
Electrical and Myocardial Remodeling in Primary Aldosteronism
Curione, M., Petramala, L., Savoriti, C., Verrenti, M., Baiocco, E., Salvatore, S., Zinnamosca, L., Iannucci, G., Sciomer, S., & Letizia, C. (2014) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2014.00007 · Cited by 12 · see citing works
Left ventricle remodeling in men with moderate to severe volume-dependent hypertension
Indra, T., Holaj, R., Zelinka, T., Petrák, O., Štrauch, B., Rosa, J., Krátká, Z., Malík, J., Janota, T., Hradec, J., et al. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312446240 · Cited by 10 · see citing works
Flagged first, then by citations
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Sorted by citations
2024 ESC Guidelines for the management of elevated blood pressure and hypertension
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298 · see citing works
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“71) compared with matched populations with essential hypertension (278,279).”
BackgroundResultFinerenone and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes
Filippatos, G., Anker, S. D., Agarwal, R., Pitt, B., Ruilope, L. M., Rossing, P., Kolkhof, P., Schloemer, P., Tornus, I., Joseph, A., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.051898 · Cited by 294 · see citing works
Jones, D. W., Ferdinand, K. C., Taler, S. J., Johnson, H. M., Shimbo, D., Abdalla, M., Altieri, M. M., Bansal, N., Bello, N. A., Bress, A. P., et al. (2025) · JACC · doi:10.1016/j.jacc.2025.05.007 · Cited by 280 · see citing works
Samnani, S., Cenzer, I., Kline, G. A., Lee, S. J., Hundemer, G. L., McClurg, C., Pasieka, J. L., Boscardin, W. J., Ronksley, P. E., & Leung, A. A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad654 · Cited by 50 · see citing works
Primary Aldosteronism: Cardiovascular Outcomes Pre- and Post-treatment
Hundemer, G. L. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1185-x · Cited by 27 · see citing works
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Stavropoulos, K., Imprialos, K. P., Katsiki, N., Petidis, K., Kamparoudis, A., Petras, P., Georgopoulou, V., Finitsis, S., Papadopoulos, C., Athyros, V. G., et al. (2018) · The Journal of Clinical Hypertension · doi:10.1111/jch.13291 · Cited by 23 · see citing works
- Authors
- Monticone, S., D'Ascenzo, F., Moretti, C., Williams, T. A., Veglio, F., Gaita, F., & Mulatero, P.
- Affiliations
- University of Turin (IT)
- LMU Klinikum (DE)
- Corresponding author
- Mulatero, Paolo
- Venue
- The Lancet Diabetes & Endocrinology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 6
- Issue
- 1
- Pages
- 41-50
- ISSN
- 2213-8587 (ISSN-L)
- OpenAlex
- W2768057265
- Cited by
- 1,072
- References
- 63
- Citations by year
- 2026: 172 · 2025: 163 · 2024: 135 · 2023: 138 · 2022: 125 · 2021: 119 · 2020: 102 · 2019: 72 · 2018: 40 · 2017: 3 · 2013: 1
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Diabetes & Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- primary aldosteronism, essential hypertension, cardiovascular events, cerebrovascular events, stroke, coronary artery disease, atrial fibrillation, heart failure, target organ damage, left ventricular hypertrophy, diabetes mellitus, metabolic syndrome, aldosterone-producing adenoma, bilateral adrenal hyperplasia, aldosterone excess, cardiovascular risk stratification
- MeSH terms
- Essential Hypertension, Cardiovascular Diseases, Humans, Hyperaldosteronism, Prognosis, Prospective Studies, Retrospective Studies
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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