The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Beyond neurotransmission: acetylcholine in immunity and inflammation
Open accessAbstract
Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule identified. ACh signalling in the neuronal cholinergic system has long been known to regulate numerous biological processes (reviewed by Beckmann and Lips). In actuality, ACh is a ubiquitous signalling molecule that is produced by numerous non‐neuronal cell types and even by some single‐celled organisms. Within multicellular organisms, a non‐neuronal cholinergic system that includes the immune system functions in parallel with the neuronal cholinergic system. Several immune cell types both respond to ACh signals and can directly produce ACh. Recent work from our laboratory has demonstrated that the capacity to produce ACh is an intrinsic property of T cells responding to viral infection, and that this ability to produce ACh is dependent upon IL‐21 signalling to the T cells. Furthermore, during infection this immune‐derived ACh is necessary for the T cells to migrate into infected tissues. In this review, we will discuss the various sources of ACh that are relevant during immune responses and describe how ACh acts on immune cells to influence their functions. We will also address the clinical implications of this fascinating aspect of immunity, focusing on ACh’s role in the migration of T cells during infection and cancer.
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Cites
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Cited by
Shehata, M. K., Ismail, A. A., & Kamel, M. A. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s417928 · Cited by 55
Metadata
- Authors
- Cox, M. A., Bassi, C., Saunders, M. E., Nechanitzky, R., Morgado‐Palacin, I., Zheng, C., & Mak, T. W.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2019-12-03
- Volume
- 287
- Issue
- 2
- Pages
- 120-133
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2988471964
- Cited by
- 189
- References
- 10
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
