Functional imaging predicts cognitive decline in Alzheimer's disease.
Abstract
Eighteen patients with Alzheimer's disease were studied with positron emission tomographic measurements of regional cerebral metabolism of glucose. All patients were initially diagnosed and evaluated, underwent positron emission tomography, and then were followed with annual reevaluations, at which time the Mini-Mental State Examination (MMSE) was performed. Patients were followed for an average of 2.5 years, and the rate of cognitive decline was calculated by determining the rate of change in the MMSE score defined as the MMSE score at the initial evaluation minus the MMSE score at the last examination, divided by the number of months between testing. The regional cerebral metabolic rates for glucose determined at the time of the first MMSE were then regressed on these changes in scores. Results showed that glucose metabolic rates in posterior temporal and primary visual cortex regions were significantly correlated with the subsequent rate of cognitive deterioration. These associations were not confounded by age, length of follow-up, baseline MMSE score, or education. Stratification on gender suggested that these associations were much stronger in women than in men. These results replicate previous findings showing that functional brain imaging is predictive of the rate of cognitive decline in Alzheimer's disease.
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Occipital regions are also atrophic in this study, although changes are not always detected in metabolic or perfusion studies of Alzheimer's disease.
“Occipital regions are also atrophic in this study; changes are not always detected in metabolic or perfusion studies of AD, in which visual cortices often serve as a control region in PET or single photon emission computed tomography imaging studies (Jagust et al., 1996).”
From Dynamics of Gray Matter Loss in Alzheimer's Disease (2003) · cites this paper as Jagust et al., 1996
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
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Self-citationDynamics of Gray Matter Loss in Alzheimer's Disease
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- Authors
- Jagust, W. J., Haan, M. N., Eberling, J. L., Wolfe, N., & Reed, B. R.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- University of California, Davis (US)
- Venue
- Journal of Neuroimaging
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 6
- Issue
- 3
- Pages
- 156-160
- ISSN
- 1051-2284 (ISSN-L)
- 1552-6569
- OpenAlex
- W2416046030
- Cited by
- 39
- References
- 15
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag007793-08)
- National Institute on Aging (P30AG010129, AG07793, AG-10129, R03AG033751)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060753)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, cognitive decline, regional cerebral glucose metabolism, positron emission tomography, posterior temporal cortex, primary visual cortex, Mini-Mental State Examination, sex differences
- MeSH terms
- Age Factors, Aged, Alzheimer Disease, Brain, Cognition, Cognition Disorders, Educational Status, Female, Follow-Up Studies, Forecasting, Glucose, Humans, Male, Mental Status Schedule, Sex Factors, Temporal Lobe, Tomography, Emission-Computed, Visual Cortex
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