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Cited by 42Hepatitis C virus researchHelicobacter pylori-related gastroenterology studiesLiver Disease Diagnosis and Treatment

Knowledge about infection is the only predictor of treatment in patients with chronic hepatitis C

Younossi, Z. M., Stepanova, M., Afendy, M., Lam, B. P., Mishra, A.·2013·Journal of Viral Hepatitis
DOI 10.1111/jvh.12080
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Abstract

Summary: HCV is the leading cause of cirrhosis and liver cancer in the U.S . The C enter for D isease C ontrol ( CDC ) has recently recommended ‘ B irth C ohort S creening’ of the U.S . Adult population to reduce the future burden of undiagnosed HCV infections in the U.S . Our aim was to assess independent predictors of receiving treatment in a cohort of HCV ‐infected patients. The H epatitis C follow‐up questionnaires of the N ational H ealth and N utrition E xamination S urveys ( NHANES ) conducted from 2001 to 2010 were used. The NHANES participants who tested positive for HCV RNA were followed by CDC 6 months after initial testing with questions related to their awareness of their infection and history or intention to receive treatment. A total of 500 NHANES participants tested positive for HCV RNA and were targeted for follow‐up. Of these, only 203 had completed the follow‐up questionnaire (response rate of 40.6%). Of these, only 101 (50%) knew about their HCV positivity before NHANES , and from them, only 34 (17%) had received treatment. In multivariate analysis, prior knowledge about their HCV infection in HCV ‐positive individuals was independently associated with receiving routine care from a doctor or HMO , with higher income, female gender, being in poor or fair health and not consuming excessive amounts of alcohol. On the other hand, the knowledge about HCV infection was the only independent predictor of receiving anti‐ HCV treatment (odds ratio 6.14). Knowledge about having HCV infection is the only independent predictor of receiving treatment. Therefore, birth cohort screening of the U.S . General population could lead to wider identification of HCV and potentially better management of the future burden of HCV and its complications.

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  • The survey was limited by nonresponse bias, although the response rate is similar to those of similar mailed efforts.

    “our survey was limited by nonresponse bias, although our response rate is similar to those of similar mailed efforts.”

    From Depression and anxiety are common among patients with cirrhosis (2022) · cites this paper as [36]

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Authors
Younossi, Z. M., Stepanova, M., Afendy, M., Lam, B. P., & Mishra, A.
Affiliations
  • Inova Health System (US)
  • Inova Fairfax Hospital (US)
Corresponding author
Younossi, Z. M.
ORCID
Venue
Journal of Viral Hepatitis
Publisher
Wiley
Published
2013-03-25
Volume
20
Issue
8
Pages
550-555
ISSN
  • 1352-0504 (ISSN-L)
  • 1365-2893
DOI
10.1111/jvh.12080
OpenAlex
W2120263188
Cited by
42
References
25
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 2
FWCI
4.57
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Viral Hepatitis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
chronic hepatitis C, HCV treatment uptake, predictors of treatment, birth cohort screening, HCV RNA, NHANES, health care utilization, socioeconomic factors, alcohol consumption
MeSH terms
Adult, Aged, Female, Humans, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Patient Acceptance of Health Care, Surveys and Questionnaires, United States, Hepatitis C, Chronic

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