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Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study

Open access
Park, Joong‐Won, Chen, Minshan, Colombo, Massimo, Roberts, Lewis R., Schwartz, Myron, Chen, Pei‐Jer, Kudo, Masatoshi, Johnson, Philip, Wagner, Samuel, Orsini, Lucinda S., Sherman, Morris·2015·Liver International

Abstract

Background & Aims: Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. The global HCC BRIDGE study was a multiregional, large‐scale, longitudinal cohort study undertaken to improve understanding of real‐life management of patients with HCC, from diagnosis to death. Methods: Data were collected retrospectively from January 2005 to September 2012 by chart reviews of eligible patients newly diagnosed with HCC at participating institutions. Results: Forty‐two sites in 14 countries contributed final data for 18 031 patients. Asia accounted for 67% of patients, Europe for 20% and North America for 13%. As expected, the most common risk factor was hepatitis C virus in North America, Europe and Japan, and hepatitis B virus in China, South Korea and Taiwan. The most common Barcelona Clinic Liver Cancer stage at diagnosis was C in North America, Europe, China and South Korea, and A in Taiwan and Japan. Across all stages, first HCC treatment was most frequently transarterial chemoembolization in North America, Europe, China and South Korea, percutaneous ethanol injection or radiofrequency ablation in Japan and resection in Taiwan. Survival from first HCC treatment varied significantly by region, with median overall survival not reached for Taiwan and 60, 33, 31, 24 and 23 months for Japan, North America, South Korea, Europe and China respectively (P < 0.0001). Conclusions: Initial results from the BRIDGE study confirm previously reported regional trends in patient demographic characteristics and HCC risk factors, document the heterogeneity of treatment approaches across regions/countries and underscore the need for earlier HCC diagnosis worldwide.

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Metadata

Authors
Park, J., Chen, M., Colombo, M., Roberts, L. R., Schwartz, M., Chen, P., Kudo, M., Johnson, P., Wagner, S., Orsini, L. S., & Sherman, M.
Venue
Liver International
Publisher
Wiley
Published
2015-03-25
Volume
35
Issue
9
Pages
2155-2166
ISSN
  • 0106-9543 (ISSN-L)
  • 1478-3223
  • 1478-3231
OpenAlex
W2028319026
Cited by
1,245
References
35
FWCI
28.82
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. https://app.cochat.ai/papers/10.1111/liv.12818
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Park, J., Chen, M., Colombo, M., Roberts, L. R., Schwartz, M., Chen, P., Kudo, M., Johnson, P., Wagner, S., Orsini, L. S., & Sherman, M. (2015). Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver International. https://doi.org/10.1111/liv.12818

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