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Cited by 62

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Immune-related hepatitis related to checkpoint inhibitors: clinical and prognostic factors

Riveiro‐Barciela, Mar, Barreira‐Díaz, Ana, Vidal‐González, Judit, Muñoz‐Couselo, Eva, Martínez‐Valle, Fernando, Viladomiu, Lluís, Mínguez, Beatriz, Ortiz‐Velez, Carolina, Castells, Lluís, Esteban, Rafael, Buti, María·2020·Liver International
DOI 10.1111/liv.14489
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Abstract

Background & Aims: Check point inhibitors (CPI) have improved survival of oncology patients but adverse effects that mimic autoimmune disorders have been reported. Our aim was describe the characteristics of immune‐related hepatitis (irH) and prognosis, and compared them to those of patients with autoimmune hepatitis (AIH). Methods: This is a retrospective study including all grade ≥ 3 (severe) irH diagnosed among 414 patients treated with CPI from 2016 to 2018. Results: Twenty‐eight cases of severe irH were recorded: 10 on anti‐CTLA‐4 ± anti‐PD1/PD‐L1 and 18 on anti‐PD1/PD‐L1. Half were female, age 63 years, median time on CPI three cycles. Four (14.3%) presented acute liver injury or failure and one (3.6%) died as consequence. 94% presented normal immunoglobulin G (IgG). Six (21.4%) patients were retreated with CPI and none presented relapse or new immune‐related adverse events after a median cycles of 11 (range 6‐36). Subjects with irH were older and had lower IgG values than a cohort of AIH (N = 38). Presentation tended to be more severe in AIH. Twenty‐five percent of irH and 84% AIH presented ANAs ≥ 1:80 ( P = .001). In irH Initial dose of corticosteroids was higher (60 vs 30 mg, P < .001) but duration shorter (2.3 vs 7 months, P < .001) and frequently in monotherapy (41.7% vs 91.3%, P < .001). Conclusions: Immune‐related hepatitis can lead to acute liver failure, with absence of increased values of IgG and ANAs. In contrast to autoimmune hepatitis, initial corticosteroids dose were higher, duration shorter with few requiring additional immunosuppression. Retreatment with CPI was not associated with recurrence.

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Crossref · 10.1111/liv.14489

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6 of 6 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 20

  1. 10.1016/j.ejca.2017.01.035 · DOI
  2. 10.1053/j.seminoncol.2015.05.013 · DOI
  3. 10.1016/j.jhep.2018.06.012 · DOI
  4. 10.1111/liv.13746 · DOI · Paper page
  5. 10.1016/j.jhep.2018.08.014 · DOI
  6. 10.1038/s41379-018-0013-y · DOI · Paper page
  7. 10.1016/j.echo.2007.11.011 · DOI
  8. 10.1016/0895-4356(93)90101-6 · DOI · Paper page
  9. 10.1016/S0168-8278(99)80297-9 · DOI · Paper page
  10. 10.1002/hep.510260305 · DOI
  11. 10.1016/j.jhep.2016.12.003 · DOI · Paper page
  12. 10.1038/clpt.2011.58 · DOI
  13. 10.1002/hep.23584 · DOI · Paper page
  14. 10.1016/j.jhep.2016.11.015 · DOI
  15. 10.1016/j.jhep.2018.01.033 · DOI · Paper page
  16. 10.1200/JCO.2015.60.8448 · DOI · Paper page
  17. 10.1097/COC.0000000000000374 · DOI · Paper page
  18. 10.1001/jamaoncol.2018.3923 · DOI · Paper page
  19. 10.1016/j.jhep.2018.03.034 · DOI
  20. 10.1001/jamaoncol.2019.1022 · DOI

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Metadata

Authors
Riveiro‐Barciela, M., Barreira‐Díaz, A., Vidal‐González, J., Muñoz‐Couselo, E., Martínez‐Valle, F., Viladomiu, L., Mínguez, B., Ortiz‐Velez, C., Castells, L., Esteban, R., & Buti, M.
Affiliations
  • Liver Unit Internal Medicine Department Hospital Universitario Vall de Hebrón Barcelona Spain
  • Oncology Department Instituto de Oncología Vall d’Hebron (VHIO) Hospital Universitario Vall de Hebrón Barcelona Spain
  • Systemic Autoimmune Diseases Unit Internal Medicine Department Hospital Universitario Vall d’Hebron Barcelona Spain
ORCID
Riveiro‐Barciela, Mar
Venue
Liver International
Publisher
Wiley
Published
2020-06-03
Volume
40
Issue
8
Pages
1906-1916
ISSN
  • 1478-3223
  • 1478-3231
DOI
10.1111/liv.14489
Cited by
62
References
6
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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