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Cited by 160Plant-Microbe Interactions and ImmunityImmune Response and InflammationInsect-Plant Interactions and Control

The function of plant PR1 and other members of the CAP protein superfamily in plant–pathogen interactions

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Han, Zhu, Xiong, Dianguang, Schneiter, Roger, Tian, Chengming·2023·Molecular Plant Pathology
DOI 10.1111/mpp.13320PMC PMC10189770
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Abstract

The pathogenesis‐related (PR) proteins of plants have originally been identified as proteins that are strongly induced upon biotic and abiotic stress. These proteins fall into 17 distinct classes (PR1–PR17). The mode of action of most of these PR proteins has been well characterized, except for PR1, which belongs to a widespread superfamily of proteins that share a common CAP domain. Proteins of this family are not only expressed in plants but also in humans and in many different pathogens, including phytopathogenic nematodes and fungi. These proteins are associated with a diverse range of physiological functions. However, their precise mode of action has remained elusive. The importance of these proteins in immune defence is illustrated by the fact that PR1 overexpression in plants results in increased resistance against pathogens. However, PR1‐like CAP proteins are also produced by pathogens and deletion of these genes results in reduced virulence, suggesting that CAP proteins can exert both defensive and offensive functions. Recent progress has revealed that plant PR1 is proteolytically cleaved to release a C‐terminal CAPE1 peptide, which is sufficient to activate an immune response. The release of this signalling peptide is blocked by pathogenic effectors to evade immune defence. Moreover, plant PR1 forms complexes with other PR family members, including PR5, also known as thaumatin, and PR14, a lipid transfer protein, to enhance the host's immune response. Here, we discuss possible functions of PR1 proteins and their interactors, particularly in light of the fact that these proteins can bind lipids, which have important immune signalling functions.

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Cited by

Sorted by citations

Authors
Han, Z., Xiong, D., Schneiter, R., & Tian, C.
Affiliations
  • University of Fribourg (CH)
  • Beijing Forestry University (CN)
Corresponding author
  • Xiong, Dianguang
  • Schneiter, Roger
ORCID
Venue
Molecular Plant Pathology
Publisher
Wiley
Published
2023-03-17
Volume
24
Issue
6
Pages
651-668
ISSN
  • 1364-3703 (ISSN-L)
  • 1464-6722
DOI
10.1111/mpp.13320
PMC
PMC10189770
OpenAlex
W4327811341
Cited by
160
References
2
Citations by year
2026: 53 · 2025: 52 · 2024: 44 · 2023: 10 · 2022: 1
FWCI
3.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Plant Pathology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Greater South Information System
Funders
  • China Scholarship Council (202106510019)
  • National Natural Science Foundation of China (31800540)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030L_182725, 310030_207870, 31003A_173003)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords
pathogenesis-related proteins, PR1, plant-pathogen interaction, plant immunity, proteolytic cleavage, virulence, PR5, thaumatin, lipid transfer proteins, lipid binding, immune signaling, disease resistance
MeSH terms
Humans, Plant Diseases, Plant Proteins, Plants, Proteins

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