Phylogenetic Distribution of Fungal Sterols
Open accessAbstract
BACKGROUND: Ergosterol has been considered the "fungal sterol" for almost 125 years; however, additional sterol data superimposed on a recent molecular phylogeny of kingdom Fungi reveals a different and more complex situation. METHODOLOGY/PRINCIPAL FINDINGS: The interpretation of sterol distribution data in a modern phylogenetic context indicates that there is a clear trend from cholesterol and other Delta(5) sterols in the earliest diverging fungal species to ergosterol in later diverging fungi. There are, however, deviations from this pattern in certain clades. Sterols of the diverse zoosporic and zygosporic forms exhibit structural diversity with cholesterol and 24-ethyl -Delta(5) sterols in zoosporic taxa, and 24-methyl sterols in zygosporic fungi. For example, each of the three monophyletic lineages of zygosporic fungi has distinctive major sterols, ergosterol in Mucorales, 22-dihydroergosterol in Dimargaritales, Harpellales, and Kickxellales (DHK clade), and 24-methyl cholesterol in Entomophthorales. Other departures from ergosterol as the dominant sterol include: 24-ethyl cholesterol in Glomeromycota, 24-ethyl cholest-7-enol and 24-ethyl-cholesta-7,24(28)-dienol in rust fungi, brassicasterol in Taphrinales and hypogeous pezizalean species, and cholesterol in Pneumocystis. CONCLUSIONS/SIGNIFICANCE: Five dominant end products of sterol biosynthesis (cholesterol, ergosterol, 24-methyl cholesterol, 24-ethyl cholesterol, brassicasterol), and intermediates in the formation of 24-ethyl cholesterol, are major sterols in 175 species of Fungi. Although most fungi in the most speciose clades have ergosterol as a major sterol, sterols are more varied than currently understood, and their distribution supports certain clades of Fungi in current fungal phylogenies. In addition to the intellectual importance of understanding evolution of sterol synthesis in fungi, there is practical importance because certain antifungal drugs (e.g., azoles) target reactions in the synthesis of ergosterol. These findings also invalidate use of ergosterol as an indicator of biomass of certain fungal taxa (e.g., Glomeromycota). Data from this study are available from the Assembling the Fungal Tree of Life (AFTOL) Structural and Biochemical Database: http://aftol.umn.edu.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ergosterol is the main membrane sterol in most fungal species and has an important role in controlling membrane fluidity.
“Similar to cholesterol in animals, ergosterol is the main membrane sterol in most fungal species, holding an important role in controlling membrane fluidity [19].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A higher-level phylogenetic classification of the Fungi
Hibbett, D. S., Binder, M., Bischoff, J. F., Blackwell, M., Cannon, P. F., Eriksson, O. E., Huhndorf, S. M., James, T. Y., Kirk, P. M., Lücking, R., et al. (2007) · Mycological Research · doi:10.1016/j.mycres.2007.03.004 · Cited by 2,388 · see citing works
Self-citationReconstructing the early evolution of Fungi using a six-gene phylogeny
James, T. Y., Kauff, F., Schoch, C. L., Matheny, P. B., Hofstetter, V., Cox, C. J., Celio, G. J., Gueidan, C., Fraker, E., Miądlikowska, J., et al. (2006) · Nature · doi:10.1038/nature05110 · Cited by 1,807 · see citing works
Sterol, Structure and Membrane Function
Bloch, K. E. (1983) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238309102790 · Cited by 677 · see citing works
Ainsworth & Bisby's Dictionary of the Fungi
Schmid, R., Hawksworth, D. L., Kirk, P. M., Sutton, B. C., & Pegler, D. N. (1996) · Taxon · doi:10.2307/1224699 · Cited by 481 · see citing works
Binder, M., Hibbett, D. S., Larsson, K., Larsson, E., Langer, E. J., & Langer, G. J. (2005) · Systematics and Biodiversity · doi:10.1017/s1477200005001623 · Cited by 403 · see citing works
Lipid Biochemistry of Fungi and Other Organisms
Weete, J. D. (1980) · Springer eBooks · doi:10.1007/978-1-4757-0064-0 · Cited by 373 · see citing works
Self-citationThe Class Mesomycetozoea: A Heterogeneous Group of Microorganisms at the Animal-Fungal Boundary
Mendoza, L., Taylor, J. W., & Ajello, L. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160950 · Cited by 322 · see citing works
Newell, S. Y., Arsuffi, T. L., & Fallon, R. D. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.7.1876-1879.1988 · Cited by 264 · see citing works
Multiple functions for sterols in Saccharomyces cerevisiae
Rodriguez, R. J., Low, C., Bottema, C. D. K., & Parks, L. W. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90057-8 · Cited by 253 · see citing works
Phylogeny of the Zygomycota based on nuclear ribosomal sequence data
White, M. M., James, T. Y., O'Donnell, K. L., Cafaro, M. J., Tanabe, Y., & Sugiyama, J. (2006) · Mycologia · doi:10.3852/mycologia.98.6.872 · Cited by 188 · see citing works
The functional importance of structural features of ergosterol in yeast.
Nes, W. R., Sekula, B. C., Nes, W. D., & Adler, J. H. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34602-1 · Cited by 161 · see citing works
Structure and Function of Sterols in Fungi
Weete, J. D. (1989) · Advances in lipid research · doi:10.1016/b978-0-12-024923-7.50007-8 · Cited by 155 · see citing works
Self-citationSalmanowicz, B. B., & Nylund, J. (1988) · European Journal of Forest Pathology · doi:10.1111/j.1439-0329.1988.tb00216.x · Cited by 139 · see citing works
Lipid Biochemistry of Fungi and Other Organisms
Packter, N. (1981) · Biochemical Education · doi:10.1016/0307-4412(81)90142-4 · Cited by 127 · see citing works
A requirement for ergosterol to permit growth of yeast sterol auxotrophs on cholestanol
Rodriguez, R. J., Taylor, F. R., & Parks, L. W. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91129-9 · Cited by 103 · see citing works
Ramgopal, M., & Bloch, K. E. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.3.712 · Cited by 90 · see citing works
Weete, J. D., Sancholle, M., & Montant, C. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90228-x · Cited by 72 · see citing works
Self-citationSterol distribution in arbuscular mycorrhizal fungi
Grandmougin‐Ferjani, A., Dalpé, Y., Hartmann, M.-A., Laruelle, F., & Sancholle, M. (1999) · Phytochemistry · doi:10.1016/s0031-9422(98)00636-0 · Cited by 71 · see citing works
Trichomycetes and Other Fungal Groups
(2001) · CRC Press eBooks · doi:10.1201/9781482279825 · Cited by 66 · see citing works
Insect-Fungus Symbiosis: Nutrition, Mutualism, and Commensalism.
Rossman, A. Y., & Batra, L. R. (1980) · Brittonia · doi:10.2307/2806805 · Cited by 64 · see citing works
Wallander, H., Massicotte, H. B., & Nylund, J. (1997) · Soil Biology and Biochemistry · doi:10.1016/s0038-0717(96)00263-5 · Cited by 59 · see citing works
Fatty acids and sterols of selected hyphochytriomycetes and chytridiomycetes
Weete, J. D., Fuller, M. S., Huang, M. Q., & Gandhi, S. R. (1989) · Experimental Mycology · doi:10.1016/0147-5975(89)90023-6 · Cited by 56 · see citing works
Self-citationSterols of the phylum Zygomycota: Phylogenetic implications
Weete, J. D., & Gandhi, S. R. (1997) · Lipids · doi:10.1007/s11745-006-0169-y · Cited by 55 · see citing works
Self-citationSterol biosynthesis by the arbuscular mycorrhizal fungus Glomus intraradices
Fontaine, J., Grandmougin‐Ferjani, A., Hartmann, M.-A., & Sancholle, M. (2001) · Lipids · doi:10.1007/s11745-001-0852-z · Cited by 42 · see citing works
Sterols and fatty acids of the Mortierellaceae: taxonomic implications
Weete, J. D., & Gandhi, S. R. (1999) · Mycologia · doi:10.1080/00275514.1999.12061063 · Cited by 38 · see citing works
Self-citationDebieu, D. (1995) · Phytochemistry · doi:10.1016/0031-9422(95)00015-y · Cited by 35 · see citing works
Distribution of sterols in fungi. II. Brassicasterol in Tuber and Terfezia species
Weete, J. D., Kulifaj, M., Montant, C., Nes, W. R., & Sancholle, M. (1985) · Canadian Journal of Microbiology · doi:10.1139/m85-212 · Cited by 35 · see citing works
Self-citationSterols and Fatty Acids of the Mortierellaceae: Taxonomic Implications
Weete, J. D., & Gandhi, S. R. (1999) · Mycologia · doi:10.2307/3761250 · Cited by 29 · see citing works
Self-citationSteroids and related natural products—X
Pettit, G. R., Green, B., KASTURI, T. R., & GHATAK, U. R. (1962) · Tetrahedron · doi:10.1016/s0040-4020(01)92749-8 · Cited by 27 · see citing works
The sterol composition of powdery mildews
Loeffler, R. S. T., Butters, J. A., & Hollomon, D. W. (1992) · Phytochemistry · doi:10.1016/0031-9422(92)83106-9 · Cited by 25 · see citing works
Harpellales (Trichomycetes); mycobionts of insecta
Moss, S. T. (1998) · Botanical Journal of Scotland · doi:10.1080/03746609808684911 · Cited by 21 · see citing works
Fatty acids and sterols ofCronartium fusiforme basidiospores
Weete, J. D., & Kelley, W. D. (1977) · Lipids · doi:10.1007/bf02533645 · Cited by 16 · see citing works
Self-citationErgosterol, the unusual dominant sterol of the pythiaceous fungus Zoophagus insidians
Warner, S. A., Sovocool, G. W., & Domnas, A. J. (1982) · Phytochemistry · doi:10.1016/0031-9422(82)83069-0 · Cited by 14 · see citing works
Steroids and Related Natural Products. XII. Fomes applanatus1, 2
Pettit, G. R., & KNIGHT, J. C. (1962) · The Journal of Organic Chemistry · doi:10.1021/jo01054a544 · Cited by 13 · see citing works
Chemistry of fungi. Part III. Constituents of Coriolus sanguineus Fr.
Cambie, R. C., & Quesne, P. W. L. (1966) · Journal of the Chemical Society C Organic · doi:10.1039/j39660000072 · Cited by 9 · see citing works
Mycelial lipids as an aid in identifying rust fungi in culture—Cronartium fusiforme
Weete, J. D., Kelley, W. D., & Hollis, C. A. (1979) · Canadian Journal of Microbiology · doi:10.1139/m79-230 · Cited by 7 · see citing works
Self-citationFatty acid metabolism inTaphrina deformans treated with sterol biosynthesis inhibitors
Weete, J. D., Sancholle, M., Patterson, K. A., Miller, K. S., Huang, M. Q., Campbell, F., & Van Den Reek, M. (1991) · Lipids · doi:10.1007/bf02536434 · Cited by 6 · see citing works
Self-citationThe Classification and Phylogeny of the Trichomycetes and Zygomycetes
Calun, M. (2001) · CRC Press eBooks · doi:10.1201/9781482279825-12 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
FungalTraits: a user-friendly traits database of fungi and fungus-like stramenopiles
Põlme, S., Abarenkov, K., Nilsson, R. H., Lindahl, B. D., Clemmensen, K. E., Kauserud, H., Nguyen, N., Kjøller, R., Bates, S. T., Baldrián, P., et al. (2020) · Fungal Diversity · doi:10.1007/s13225-020-00466-2 · Cited by 1,151 · see citing works
Biosynthesis of Cholesterol and Other Sterols
Nes, W. D. (2011) · Chemical Reviews · doi:10.1021/cr200021m · Cited by 635 · see citing works
Fungal evolution: diversity, taxonomy and phylogeny of the Fungi
Naranjo-Ortíz, M. A., & Gabaldón, T. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12550 · Cited by 401 · see citing works
Propagating annotations of molecular networks using in silico fragmentation
Silva, R., Wang, M., Nothias-Scaglia, L.-F., van der Hooft, J. J. J., Caraballo‐Rodríguez, A. M., Fox, E., Balunas, M. J., Klassen, J. L., Lopes, N. P., & Dorrestein, P. C. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006089 · Cited by 361 · see citing works
Vega, F. E., Meyling, N. V., Luangsa-ard, J. J., & Blackwell, M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384984-7.00006-3 · Cited by 361 · see citing works
Self-citationA Review of Mushrooms as a Potential Source of Dietary Vitamin D
Cardwell, G., Bornman, J. F., James, A. P., & Black, L. J. (2018) · Nutrients · doi:10.3390/nu10101498 · Cited by 348 · see citing works
Potential of Chlorella as a Dietary Supplement to Promote Human Health
Bito, T., Okumura, E., Fujishima, M., & Watanabe, F. (2020) · Nutrients · doi:10.3390/nu12092524 · Cited by 326 · see citing works
Enkavi, G., Javanainen, M., Kulig, W., Róg, T., & Vattulainen, I. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00538 · Cited by 285 · see citing works
The Fungal Tree of Life: from Molecular Systematics to Genome-Scale Phylogenies
Spatafora, J., Aime, M. C., Grigoriev, I., Martin, F., Stajich, J., & Blackwell, M. (2017) · Microbiology spectrum · doi:10.1128/microbiolspec.funk-0053-2016 · Cited by 233 · see citing works
Self-citationAncient steroids establish the Ediacaran fossil<i>Dickinsonia</i>as one of the earliest animals
Bobrovskiy, I., Hope, J. M., Ivantsov, A., Nettersheim, B. J., Hallmann, C., & Brocks, J. J. (2018) · Science · doi:10.1126/science.aat7228 · Cited by 236 · see citing works
Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
Ksiezopolska, E., & Gabaldón, T. (2018) · Genes · doi:10.3390/genes9090461 · Cited by 230 · see citing works
ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND?
Dupont, S., Lemetais, G., Ferreira, T., Cayot, P., Gervais, P., & Beney, L. (2012) · Evolution · doi:10.1111/j.1558-5646.2012.01667.x · Cited by 233 · see citing works
Distribution and Functions of Sterols and SphingolipidsPreprint
Hannich, J. T., Umebayashi, K., & Riezman, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004762 · Cited by 193 · see citing works
Fan, J., Urban, M., Parker, J. E., Brewer, H. C., Kelly, S. L., Hammond-Kosack, K. E., FRAAIJE, B. A., Liu, X., & Cools, H. J. (2013) · New Phytologist · doi:10.1111/nph.12193 · Cited by 175 · see citing works
Kodedová, M., & Sychrová, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139306 · Cited by 177 · see citing works
Prost, K., Birk, J. J., Lehndorff, E., Gerlach, R., & Amelung, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0164882 · Cited by 167 · see citing works
Han, Z., Xiong, D., Schneiter, R., & Tian, C. (2023) · Molecular Plant Pathology · doi:10.1111/mpp.13320 · Cited by 160 · see citing works
Saslis‐Lagoudakis, C. H., Klitgaard, B. B., Forest, F., Francis, L., Savolainen, V., Williamson, E. M., & Hawkins, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022275 · Cited by 160 · see citing works
Sterol and genomic analyses validate the sponge biomarker hypothesis
Gold, D. A., Grabenstatter, J., de Mendoza, A., Riesgo, A., Ruiz-Trillo, I., & Summons, R. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512614113 · Cited by 145 · see citing works
Sandargo, B., Chepkirui, C., Cheng, T., Chaverra-Muñoz, L., Thongbai, B., Stadler, M., & Hüttel, S. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.01.011 · Cited by 151 · see citing works
Plasma membrane lipids and their role in fungal virulence
Rella, A., Farnoud, A. M., & Poeta, M. D. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.11.003 · Cited by 150 · see citing works
Steroid-transforming enzymes in fungi
Kristan, K., & Rižner, T. L. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.08.012 · Cited by 149 · see citing works
Parro, V., de Diego-Castilla, G., Moreno‐Paz, M., Blanco, Y., Cruz‐Gil, P., Rodríguez-Manfredi, J. A., Fernández‐Remolar, D. C., Gómez, F., Gómez, M. J., Rivas, L. A., et al. (2011) · Astrobiology · doi:10.1089/ast.2011.0654 · Cited by 138 · see citing works
Pogozheva, I. D., Armstrong, G. A., Kong, L., Hartnagel, T. J., Carpino, C. A., Gee, S. E., Picarello, D. M., Rubin, A. S., Lee, J., Park, S., et al. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c01514 · Cited by 135 · see citing works
Vallejo, M. C., Nakayasu, E. S., Longo, L. V. G., Ganiko, L., Lopes, F. G., Matsuo, A. L., de Almeida, I. C., & Puccia, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039463 · Cited by 134 · see citing works
Kramer, S., Marhan, S., Rueß, L., Armbruster, W., Butenschoen, O., Haslwimmer, H., Kuzyakov, Y. V., Pausch, J., Scheunemann, N., Schoene, J., et al. (2011) · Pedobiologia · doi:10.1016/j.pedobi.2011.12.001 · Cited by 128 · see citing works
Lee, J., Kim, Y., Khadke, S. K., & Lee, J. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13710 · Cited by 120 · see citing works
Davey, M. L., Heegaard, E., Halvorsen, R., Ohlson, M., & Kauserud, H. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04215.x · Cited by 116 · see citing works
Perczak, A., Gwiazdowska, D., Marchwińska, K., Juś, K., Gwiazdowski, R., & Waśkiewicz, A. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01673-5 · Cited by 115 · see citing works
Arctic marine fungi: biomass, functional genes, and putative ecological roles
Hassett, B. T., Borrego, E. J., Vonnahme, T. R., Rämä, T., Kolomiets, M. V., & Gradinger, R. (2019) · The ISME Journal · doi:10.1038/s41396-019-0368-1 · Cited by 102 · see citing works
Nature of sterols affects plasma membrane behavior and yeast survival during dehydration
Dupont, S., Beney, L., Ferreira, T., & Gervais, P. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.11.012 · Cited by 102 · see citing works
Tracking the sterol biosynthesis pathway of the diatom P haeodactylum tricornutum
Fabris, M., Matthijs, M., Carbonelle, S., Moses, T., Pollier, J., Dasseville, R., Baart, G. J. E., Vyverman, W., & Goossens, A. (2014) · New Phytologist · doi:10.1111/nph.12917 · Cited by 96 · see citing works
Hammann, S., & Cramp, L. (2018) · Journal of Archaeological Science · doi:10.1016/j.jas.2018.02.017 · Cited by 96 · see citing works
A Molecular Window into the Biology and Epidemiology of Pneumocystis spp
Ma, L., Cissé, O. H., & Kovacs, J. A. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00009-18 · Cited by 94 · see citing works
Inserra, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00330 · Cited by 91 · see citing works
Agha, R., Saebelfeld, M., Manthey, C., Rohrlack, T., & Wolinska, J. (2016) · Scientific Reports · doi:10.1038/srep35039 · Cited by 89 · see citing works
What Defines the “Kingdom” Fungi?
Richards, T. A., Leonard, G., & Wideman, J. G. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0044-2017 · Cited by 87 · see citing works
Antioxidant Properties of Ergosterol and Its Role in Yeast Resistance to Oxidation
Dupont, S., Fleurat‐Lessard, P., da Cruz, R. G., Lafarge, C., Grangeteau, C., Yahou, F., Gerbeau‐Pissot, P., Abrahão, O., Gervais, P., Simon-Plas, F., et al. (2021) · Antioxidants · doi:10.3390/antiox10071024 · Cited by 87 · see citing works
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Ho, N., Yap, W. S., Xu, J., Wu, H., Koh, J. H., Goh, W. W. B., George, B., Chong, S. C., Taubert, S., & Thibault, G. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201909165 · Cited by 79 · see citing works
Shyu, P. T., Ng, B. S. H., Ho, N., Chaw, R., Seah, Y. L., Marvalim, C., & Thibault, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-45020-6 · Cited by 82 · see citing works
Polanowska, K., Grygier, A., Kuligowski, M., Rudzińska, M., & Nowak, J. S. (2020) · LWT · doi:10.1016/j.lwt.2020.109024 · Cited by 83 · see citing works
A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis
Pollier, J., Vancaester, E., Kuzhiumparambil, U., Vickers, C., Vandepoele, K., Goossens, A., & Fabris, M. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0305-5 · Cited by 71 · see citing works
Blosser, S. J., & Cramer, R. A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05027-11 · Cited by 79 · see citing works
Diploid-dominant life cycles characterize the early evolution of Fungi
Amses, K. R., Simmons, D. R., Longcore, J. E., Mondo, S. J., Seto, K., Jerônimo, G. H., Bonds, A. E., Quandt, C. A., Davis, W. J., Chang, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116841119 · Cited by 78 · see citing works
Genome analysis of medicinal Ganoderma spp. with plant-pathogenic and saprotrophic life-styles
Kües, U., Nelson, D. R., Liu, C., Yu, G., Zhang, J., Li, J., Wang, X., & Sun, H. Z. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2014.11.019 · Cited by 76 · see citing works
Stoichiometry of the soil microbial biomass in response to amendments with varying C/N/P/S ratios
Khan, K. S., & Joergensen, R. G. (2019) · Biology and Fertility of Soils · doi:10.1007/s00374-019-01346-x · Cited by 76 · see citing works
Awad, A., Majcherczyk, A., Schall, P., Schröter, K., Schöning, I., Schrumpf, M., Ehbrecht, M., Boch, S., Kahl, T., Bauhus, J., et al. (2018) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2018.12.014 · Cited by 74 · see citing works
Davey, M. L., Heegaard, E., Halvorsen, R., Kauserud, H., & Ohlson, M. (2012) · Molecular Ecology · doi:10.1111/mec.12122 · Cited by 73 · see citing works
Linking Soil Biotic and Abiotic Factors to Apple Replant Disease: a Greenhouse Approach
Spath, M., Insam, H., Peintner, U., Kelderer, M., Kuhnert-Finkernagel, R., & Franke, I. H. (2014) · Journal of Phytopathology · doi:10.1111/jph.12318 · Cited by 71 · see citing works
Tang, M., Li, L., Wang, X., You, J., Li, J., & Chen, X. (2020) · Scientific Reports · doi:10.1038/s41598-020-69441-w · Cited by 70 · see citing works
Bhople, P., Keiblinger, K. M., Djukic, I., Liu, D., Zehetner, F., Zechmeister‐Boltenstern, S., Joergensen, R. G., & Murugan, R. (2021) · Geoderma · doi:10.1016/j.geoderma.2020.114922 · Cited by 69 · see citing works
Bitter and sweet make tomato hard to (b)eat
You, Y., & van Kan, J. A. L. (2020) · New Phytologist · doi:10.1111/nph.17104 · Cited by 68 · see citing works
Carter, H. E., FRAAIJE, B. A., West, J. S., Kelly, S. L., Mehl, A., Shaw, M. W., & Cools, H. J. (2013) · Molecular Plant Pathology · doi:10.1111/mpp.12106 · Cited by 66 · see citing works
Ramírez, A. M. C., Amézquita, A., Cardona, J., Matiz-Céron, L., Andrade-Martínez, J. S., Triana, S., Mantilla, M. J., Restrepo, S., Barrios, A. F. G., & de Cock, H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00338 · Cited by 66 · see citing works
The Fungal Tree of Life: From Molecular Systematics to Genome-Scale Phylogenies
Spatafora, J. W., Aime, M. C., Grigoriev, I. V., Martin, F. M., Stajich, J., & Blackwell, M. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch1 · Cited by 67 · see citing works
Self-citationStructure and Biological Activity of Ergostane-Type Steroids from Fungi
Zhabinskii, V. N., Drašar, P., & Khripach, V. A. (2022) · Molecules · doi:10.3390/molecules27072103 · Cited by 65 · see citing works
Fungal Growth and Biomass Development is Boosted by Plants in Snow-Covered Soil
Kuhnert-Finkernagel, R., Oberkofler, I., & Peintner, U. (2012) · Microbial Ecology · doi:10.1007/s00248-011-0001-y · Cited by 63 · see citing works
Lopes, G., Sousa, C., Valentão, P., & Andrade, P. B. (2013) · doi:10.1002/9781118412893.ch9 · Cited by 63 · see citing works
Phillips, K. M., Horst, R. L., Koszewski, N. J., & Simon, R. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040702 · Cited by 62 · see citing works
Zhang, X., Lin, K., & Li, Y. (2020) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2020.08.021 · Cited by 62 · see citing works
Olsson, P. A., & Lekberg, Y. (2022) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2022.108574 · Cited by 61 · see citing works
Peeling the onion: the outer layers of Cryptococcus neoformans
Agustinho, D. P., Miller, L., Li, L. X., & Doering, T. L. (2018) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760180040 · Cited by 62 · see citing works
Gerphagnon, M., Agha, R., Martin‐Creuzburg, D., Bec, A., Pérrière, F., Rad‐Menéndez, C., Gachon, C. M. M., & Wolinska, J. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14489 · Cited by 61 · see citing works
Merényi, Z., Krizsán, K., Sahu, N., Liu, X., Bálint, B., Stajich, J., Spatafora, J. W., & Nagy, L. G. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-023-02095-9 · Cited by 60 · see citing works
Benny, G. L., Humber, R. A., & Voigt, K. (2014) · Springer eBooks · doi:10.1007/978-3-642-55318-9_8 · Cited by 60 · see citing works
Characterization of mycelia from wood-decay species by TGA and IR spectroscopy
Girometta, C. E., Dondi, D., Baiguera, R. M., Bracco, F., Branciforti, D. S., Buratti, S., Lazzaroni, S., & Savino, E. (2020) · Cellulose · doi:10.1007/s10570-020-03208-4 · Cited by 59 · see citing works
Corrêa, R. C. G., Peralta, R. M., Bracht, A., & Ferreira, I. C. F. R. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.06.012 · Cited by 59 · see citing works
Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp
Eliaš, D., Tóth Hervay, N., & Gbelská, Y. (2024) · Stresses · doi:10.3390/stresses4040041 · Cited by 63 · see citing works
The biology and chemistry of a mutualism between a soil bacterium and a mycorrhizal fungus
Anckaert, A., Declerck, S., Poussart, L.-A., Lambert, S., Helmus, C., Boubsi, F., Steels, S., Arias, A. A., Calonne-Salmon, M., & Ongena, M. (2024) · Current Biology · doi:10.1016/j.cub.2024.09.019 · Cited by 56 · see citing works
Fungal Decomposers in Freshwater Environments
Gulis, V., Su, R., & Kuehn, K. A. (2019) · Advances in environmental microbiology · doi:10.1007/978-3-030-16775-2_5 · Cited by 53 · see citing works
Sánchez-Maldonado, A. F., Schieber, A., & Gänzle, M. G. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13056 · Cited by 54 · see citing works
Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans
de Oliveira, F. F. M., Paes, H. C., Peconick, L. D. F., Fonseca, F. L., Marina, C. L., Bocca, A. L., Homem-de-Mello, M., Rodrigues, M. L., Albuquerque, P., Nicola, A. M., et al. (2020) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2020.103368 · Cited by 50 · see citing works
Deng, G., Yang, Q., He, W., Li, C., Yang, J., Zuo, C.-W., Gao, J., Sheng, O., Lu, S., Zhang, S., et al. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6768-x · Cited by 52 · see citing works
Sterol Biosynthesis Inhibitors
Kuck, K., Stenzel, K., & Vors, J. (2011) · doi:10.1002/9783527644179.ch19 · Cited by 53 · see citing works
A hitchhiker’s guide: estimates of microbial biomass and microbial gene abundance in soil
Joergensen, R. G., Hemkemeyer, M., Beule, L., Iskakova, J., Oskonbaeva, Z., Rummel, P. S., Schwalb, S. A., & Wichern, F. (2024) · Biology and Fertility of Soils · doi:10.1007/s00374-024-01810-3 · Cited by 52 · see citing works
Rahimi-Verki, N., Shapoorzadeh, A., Razzaghi‐Abyaneh, M., Atyabi, S.-M., Shams‐Ghahfarokhi, M., Jahanshiri, Z., & Gholami‐Shabani, M. (2015) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2015.12.007 · Cited by 52 · see citing works
Pacifico, D., Lanzanova, C., Pagnotta, E., Bassolino, L., Mastrangelo, A. M., Marone, D., Matteo, R., Scalzo, R. L., & Balconi, C. (2021) · Molecules · doi:10.3390/molecules26082174 · Cited by 49 · see citing works
Guo, Z., Liu, X., Wang, N., Mo, P., Shen, J., Liu, M., Zhang, H., Wang, P., & Zhang, Z. (2022) · New Phytologist · doi:10.1111/nph.18575 · Cited by 49 · see citing works
Toxic eburicol accumulation drives the antifungal activity of azoles against Aspergillus fumigatus
Elsaman, H., Golubtsov, E., Brazil, S., Ng, N., Klugherz, I., Martin, R., Dichtl, K., Müller, C., & Wagener, J. (2024) · Nature Communications · doi:10.1038/s41467-024-50609-1 · Cited by 50 · see citing works
Sharma, R., Gassel, S., Steiger, S., Xia, X., Bauer, R., Sandmann, G., & Thines, M. (2015) · BMC Genomics · doi:10.1186/s12864-015-1380-0 · Cited by 49 · see citing works
Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport
Соколов, С. С., Trushina, N. I., Severin, F. F., & Кнорре, Д. А. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919040023 · Cited by 47 · see citing works
Boron paleosalinity proxy for deeply buried Paleozoic and Ediacaran fossils
Retallack, G. J. (2019) · Palaeogeography Palaeoclimatology Palaeoecology · doi:10.1016/j.palaeo.2019.109536 · Cited by 45 · see citing works
Eilam, Y., Pintel, N., Khattib, H., Shagug, N., Taha, R., & Avni, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213667 · Cited by 48 · see citing works
Benny, G. L., Smith, M. E., Kirk, P. M., Tretter, E. D., & White, M. M. (2016) · Fungal biology · doi:10.1007/978-3-319-29137-6_5 · Cited by 44 · see citing works
Fagundes, M. B., Falk, R. B., Facchi, M. M. X., Vendruscolo, R. G., Maroneze, M. M., Zepka, L. Q., Lopes, E. J., & Wagner, R. C. (2018) · Food Research International · doi:10.1016/j.foodres.2018.10.060 · Cited by 44 · see citing works
De novo phytosterol synthesis in animals
Michellod, D., Bien, T., Birgel, D., Violette, M. J., Kleiner, M., Fearn, S., Zeidler, C., Gruber‐Vodicka, H. R., Dubilier, N., & Liebeke, M. (2023) · Science · doi:10.1126/science.add7830 · Cited by 43 · see citing works
Targeting pathogen sterols: Defence and counterdefence?
Kazan, K., & Gardiner, D. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006297 · Cited by 43 · see citing works
Bhople, P., Djukic, I., Keiblinger, K. M., Zehetner, F., Liu, D., Bierbaumer, M., Zechmeister‐Boltenstern, S., Joergensen, R. G., & Murugan, R. (2019) · Geoderma · doi:10.1016/j.geoderma.2019.03.022 · Cited by 43 · see citing works
Engineering Cell Wall Integrity Enables Enhanced Squalene Production in Yeast
Son, S., Kim, J.-E., Oh, S. S., & Lee, J. Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00967 · Cited by 42 · see citing works
Diversity and biomass dynamics of unicellular marine fungi during a spring phytoplankton bloom
Priest, T., Fuchs, B. M., Amann, R., & Reich, M. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15331 · Cited by 42 · see citing works
Heim, C., Quéric, N. V., Ionescu, D., Schäfer, N., & Joachim Reitner, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177542 · Cited by 40 · see citing works
Wang, Y., Sen, K., He, Y., Xie, Y., & Wang, G. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.204 · Cited by 41 · see citing works
Ergosterol as an objective indicator for grape rot and fungal biomass in grapes
Porep, J. U., Walter, R., Kortekamp, A., & Carle, R. (2013) · Food Control · doi:10.1016/j.foodcont.2013.09.012 · Cited by 40 · see citing works
Zheng, B., Yan, L., Liang, W., & Yang, Q. (2018) · Pest Management Science · doi:10.1002/ps.5127 · Cited by 39 · see citing works
Cline, L. C., Huggins, J. A., Hobbie, S. E., & Kennedy, P. G. (2018) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2018.07.008 · Cited by 38 · see citing works
Teixeira, T. R., dos Santos, G. S., Turatti, I. C. C., Paziani, M. H., Kress, M. R. V. Z., Colepicolo, P., & Debonsi, H. M. (2019) · Polar Biology · doi:10.1007/s00300-019-02529-w · Cited by 38 · see citing works
Rainfall drives atmospheric ice-nucleating particles in the coastal climate of southern Norway
Conen, F., Eckhardt, S., Gundersen, H., Stohl, A., & Yttri, K. E. (2017) · Atmospheric chemistry and physics · doi:10.5194/acp-17-11065-2017 · Cited by 37 · see citing works
Haubrich, B. A., Collins, E. K., Howard, A. L., Wang, Q., Snell, W. J., Miller, M. B., Thomas, C. D., Pleasant, S. K., & Nes, W. D. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.07.019 · Cited by 37 · see citing works
Topical Voriconazole as Supplemental Treatment for Acanthamoeba Keratitis
Musayeva, A., Riedl, J. C., Schuster, A. K.-G., Wasielica‐Poslednik, J., Pfeiffer, N., & Gericke, A. (2020) · Cornea · doi:10.1097/ico.0000000000002315 · Cited by 36 · see citing works
Gorka, S., Darcy, S. R., Horak, J., Imai, B., Mohrlok, M., Salas, E., Richter, A. A., Schmidt, H., Wanek, W., Kaiser, C., et al. (2023) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2023.109205 · Cited by 35 · see citing works
- Authors
- Weete, J. D., Abril, M., & Blackwell, M.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Blackwell, Meredith
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-05-28
- Volume
- 5
- Issue
- 5
- Pages
- e10899
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2878339
- OpenAlex
- W2043642851
- Cited by
- 316
- References
- 37
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 23 · 2023: 28 · 2022: 25 · 2021: 22 · 2020: 36 · 2019: 28 · 2018: 22 · 2017: 18 · 2016: 12 · 2015: 13 · 2014: 9 · 2013: 8 · 2012: 12
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation (0732671)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- fungal sterols, ergosterol, sterol biosynthesis, fungal phylogeny, cholesterol, brassicasterol, rust fungi, Glomeromycota, zoosporic fungi, azole antifungals
- MeSH terms
- Fungi, Phylogeny, Seawater, Sterols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
