CoChat
Sign Up
Cited by 119Cerebrospinal fluid and hydrocephalusIon Transport and Channel RegulationTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.

Astrogliosis and impaired aquaporin‐4 and dystrophin systems in idiopathic normal pressure hydrocephalus

Eide, P. K., Hansson, H.‐A.·2018·Neuropathology and Applied Neurobiology
DOI 10.1111/nan.12420
Open this paper in CoChat — free account

Abstract

Aims: Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia that may improve following drainage of cerebrospinal fluid (CSF). This prospective observational study explored whether expression of the water channel aquaporin‐4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient. Observations were related to measurements of pulsatile and static intracranial pressure (ICP). Methods: The study included iNPH patients undergoing overnight monitoring of the pulsatile/static ICP in whom a biopsy was taken from the frontal cerebral cortex during placement of the ICP sensor. Reference (Ref) biopsies were sampled from 13 patients who underwent brain surgery for epilepsy, tumours or cerebral aneurysms. The brain tissue specimens were examined by light microscopy, immunohistochemistry, densitometry and morphometry. Results: iNPH patients responding to surgery ( n = 44) had elevated pulsatile ICP, indicative of impaired intracranial compliance. As compared to the Ref patients, the cortical biopsies of iNPH patients revealed prominent astrogliosis and reduced expression of AQP4 and Dp71 immunoreactivities in the astrocytic perivascular endfeet and in parts of the adjacent neuropil. There was a significant correlation between degree of astrogliosis and reduction of AQP4 and Dp71 at astrocytic perivascular endfeet. Conclusions: Idiopathic normal pressure hydrocephalus patients responding to CSF diversion present with abnormal pulsatile ICP, indicative of impaired intracranial compliance. A main histopathological finding was astrogliosis and reduction of AQP4 and of Dp71 in astrocytic perivascular endfeet. We propose that the altered AQP4 and Dp71 complex contributes to the subischaemia prevalent in the brain tissue of iNPH.

Overview

Integrity signals

Registry

Crossref · 10.1111/nan.12420

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 64 references

1 of the 64 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Winters HV, 2015, Greenfield's Neuropathology, 1

Cited by

Sorted by citations

See all 119

Related

Metadata

Authors
Eide, P. K., & Hansson, H. ‐.
Affiliations
  • Oslo University Hospital (NO)
  • University of Gothenburg (SE)
Corresponding author
Eide, P. K.
ORCID
Venue
Neuropathology and Applied Neurobiology
Publisher
Wiley
Published
2017-07-19
Volume
44
Issue
5
Pages
474-490
ISSN
  • 0305-1846 (ISSN-L)
  • 1365-2990
DOI
10.1111/nan.12420
OpenAlex
W2664710281
Cited by
119
References
64
Citations by year
2026: 13 · 2025: 18 · 2024: 14 · 2023: 18 · 2022: 18 · 2021: 13 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 2
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Neuropathology and Applied Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Stiftelserna Wilhelm och Martina Lundgrens
Topics
  • Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
idiopathic normal pressure hydrocephalus, astrocyte activation, aquaporin-4, intracranial compliance, cerebrospinal fluid drainage
MeSH terms
Aged, Female, Gliosis, Humans, Hydrocephalus, Normal Pressure, Male, Middle Aged, Dystrophin, Aquaporin 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review