Rome III vs Rome IV criteria for irritable bowel syndrome: A comparison of clinical characteristics in a large cohort study
Open accessAbstract
Background: The Rome criteria for irritable bowel syndrome (IBS) have been revised and are expected to apply only to the subset of Rome III IBS subjects with abdominal pain as predominant symptom, occurring at least once a week. The aim of this study was to determine the percentage of Rome III IBS subjects that fulfills Rome IV criteria and to evaluate differences between Rome IV‐positive and Rome IV‐negative subjects. Methods: Four hundred and four Rome III IBS subjects completed a 14‐day end‐of‐day symptom diary, the Gastrointestinal Symptom Rating Scale (GSRS), Hospital Anxiety and Depression Scale, and RAND 36‐item Short‐Form Health Survey (SF‐36). Diary‐based surrogate Rome IV criteria were defined as occurrence of abdominal pain at least 1 day each week with a severity of ≥2 (mild; definition 1) or ≥3 (considerable; definition 2). Key Results: Using surrogate Rome IV criteria, 353 (87.4%, definition 1) and 249 (61.6%, definition 2) subjects were defined as Rome IV positive. These patients were more often female, younger, and recruited from secondary/tertiary care compared with Rome IV‐negative subjects. They also presented with higher abdominal pain scores and gastrointestinal (GI) symptom severity on both end‐of‐day diary and GSRS, higher psychological symptom scores, and lower quality of life compared with Rome IV‐negative subjects. Conclusions and Inferences: The Rome IV IBS population likely reflects a subgroup of Rome III IBS patients with more severe GI symptomatology, psychological comorbidities, and lower quality of life. This implies that results from Rome III IBS studies may not be directly comparable to those from Rome IV IBS populations.
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- Authors
- Vork, L., Weerts, Z. Z. R. M., Mujagic, Z., Kruimel, J. W., Hesselink, M. A. M., Muris, J. W. M., Keszthelyi, D., Jonkers, D. M. A. E., & Masclee, A. A. M.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Corresponding author
- Vork, L.
- ORCID
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2017-08-14
- Volume
- 30
- Issue
- 2
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2748216236
- Cited by
- 101
- References
- 25
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 13 · 2021: 18 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 1
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- irritable bowel syndrome, Rome III criteria, Rome IV criteria, diagnostic criteria comparison, abdominal pain, gastrointestinal symptom severity, quality of life, anxiety and depression, symptom diary, patient subgroups
- MeSH terms
- Female, Humans, Male, Surveys and Questionnaires, Severity of Illness Index, Cohort Studies, Abdominal Pain, Irritable Bowel Syndrome
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