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Cited by 7Cellular transport and secretionFungal and yeast genetics researchPlant Pathogens and Fungal Diseases

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Golgi‐associated retrograde protein ( GARP ) complex recruits retromer to trans ‐Golgi network for FgKex2 and FgSnc1 recycling, necessary for the development and pathogenicity of Fusarium graminearum

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Long, Yunfei, Chen, Xin, Chen, Jia, Zhang, Haoran, Lin, Ying, Cheng, Shuyuan, Pu, Neng, Zhou, Xuandong, Sheng, Renzhi, Abubakar, Yakubu Saddeeq, Zheng, Huawei, Yun, Yingzi, Lu, Guodong, Wang, Zonghua, Zheng, Wenhui·2025·New Phytologist
DOI 10.1111/nph.70006

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Abstract

Summary: In eukaryotes, the retromer complex plays a crucial role in the sorting and retrograde transport of cargo proteins from endosomes to the trans ‐Golgi network (TGN). Despite its importance, the molecular details of this intracellular transport process remain unclear. Here, we have identified a Golgi‐associated retrograde protein (GARP) complex as a mediator of vesicle transport that facilitates the recruitment of the retromer complex to the TGN to exert its functions. The GARP complex is mainly localized in the TGN where it interacts with the retromer complex. This interaction is evolutionarily conserved across species. Furthermore, we identified FgKex2 and FgSnc1 as cargo proteins in the GARP/retromer‐mediated recycling pathway. Loss of GARP or retromer results in a complete missorting of FgKex2 and FgSnc1 into the vacuolar degradation pathway, which affects the growth, development, biogenesis of toxisomes and pathogenicity of Fusarium graminearum . In summary, we demonstrate for the first time that GARP promotes the recruitment of retromer from endosomes to the TGN, thereby establishing a GARP/retromer transport pathway that coordinates the recycling of cargo proteins FgKex2 and FgSnc1. This process is essential for maintaining sustained growth and development and significantly contributes to the pathogenicity of F. graminearum .

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Metadata

Authors
Long, Y., Chen, X., Chen, J., Zhang, H., Lin, Y., Cheng, S., Pu, N., Zhou, X., Sheng, R., Abubakar, Y. S., Zheng, H., Yun, Y., Lu, G., Wang, Z., & Zheng, W.
Affiliations
  • Fujian Agriculture and Forestry University (CN)
  • Jiangxi Agricultural University College of Agriculture Nanchang Jiangxi 330000 China
  • Agricultural and Rural Comprehensive Service Center Shuitang Town Xinping County Yunnan 653400 China
  • Ahmadu Bello University (NG)
  • Minjiang University (CN)
Corresponding author
Zheng, Wenhui
ORCID
Venue
New Phytologist
Publisher
Wiley
Published
2025-02-15
Volume
246
Issue
2
Pages
666-688
ISSN
  • 0028-646X (ISSN-L)
  • 1469-8137
DOI
10.1111/nph.70006
OpenAlex
W4407605929
Cited by
7
References
2
Citations by year
2026: 4 · 2025: 2
FWCI
3.00
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • New Phytologist (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Fujian Province (2021J06015)
  • National Natural Science Foundation of China (32122071, 32272481)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
Keywords
GARP complex, retromer complex, trans-Golgi network, retrograde transport, protein recycling, Fusarium graminearum, fungal pathogenicity, endosomal sorting, vesicle trafficking
MeSH terms
Fungal Proteins, Fusarium, Golgi Apparatus, Protein Binding, Endosomes, Vacuoles, Virulence, Protein Transport, trans-Golgi Network, Vesicular Transport Proteins

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