The role of lymph node sinus macrophages in host defense
Abstract
Strategically positioned along lymphatic vessels, lymph nodes act as filter stations preventing systemic pathogen dissemination; they are primary sites of innate immune responses and provide the staging grounds for the generation of adaptive immunity. Critical mediators of these lymph node functions are two phenotypically and functionally distinct subsets of macrophages: the subcapsular sinus macrophages and the medullary macrophages. This review focuses on the phenotype and function of these lymph node sinus-resident macrophages and summarizes methods for their proper identification and experimental manipulation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SCS sinus macrophages can capture larger molecules, viruses, and bacteria and can mount a protective immune response even in the absence of antigen-presenting DCs.
“These macrophages can capture larger molecules, viruses, and bacteria (89, 90) and are capable of mounting a protective immune response even in the absence of antigen-presenting DCs (91).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [89]
Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works
Trophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178 · see citing works
Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., et al. (2007) · Nature · doi:10.1038/nature06287 · Cited by 846 · see citing works
Self-citationLinehan, S. A., Martínez-Pomares, L., Stahl, P. D., & Gordon, S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1961 · Cited by 285 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bernsmeier, C., Pop, O. T., Singanayagam, A., Triantafyllou, E., Patel, V. C., Weston, C. J., Curbishley, S., Sadiq, F., Vergis, N., Khamri, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.11.045 · Cited by 287 · see citing works
Transport and Immune Functions of the Lymphatic System.
Davis, M. J., Zawieja, S. D., & King, P. D. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-104908 · Cited by 42 · see citing works
- Authors
- Kuka, M., & Iannacone, M.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Iannacone, Matteo
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2014-03-04
- Volume
- 1319
- Issue
- 1
- Pages
- 38-46
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1502600357
- Cited by
- 80
- References
- 4
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 5 · 2014: 3
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- European Research Council (281648)
- Associazione italiana per la Ricerca sul Cancro (9965)
- Giovanni Armenise-Harvard Foundation (Career Development Award)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- lymph node macrophages, subcapsular sinus macrophages, host defense, innate immunity, adaptive immunity, macrophage phenotype, macrophage identification
- MeSH terms
- Animals, Humans, Immunity, Innate, Lymph Nodes, Macrophages, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
