Cited by 219PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

Open access

Perl, Andras·2015·Annals of the New York Academy of Sciences

Open this paper in CoChat — free account

Abstract

The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase, which plays pivotal roles in integrating growth signals on a cellular level. To support proliferation and survival under stress, two interacting complexes that harbor mTOR, mTORC1 and mTORC2, promote the transcription of genes involved in carbohydrate metabolism and lipogenesis, enhance protein translation, and inhibit autophagy. Although rapamycin was originally developed as an inhibitor of T cell proliferation for preventing organ transplant rejection, its molecular target, mTOR, has been subsequently identified as a central regulator of metabolic cues that drive lineage specification in the immune system. Owing to oxidative stress, the activation of mTORC1 has emerged as a central pathway for the pathogenesis of systemic lupus erythematosus and other autoimmune diseases. Paradoxically, mTORC1 has also been identified as a mediator of the Warburg effect that allows cell survival under hypoxia. Rapamycin and new classes of mTOR inhibitors are being developed to block not only transplant rejection and autoimmunity but also to treat obesity and various forms of cancer. Through preventing these diseases, personalized mTOR blockade holds promise to extend life span.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/nyas.12756

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
Hochberg, M. C. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400928 · Cited by 11,409
International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Surfing the p53 network
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
Petri, M., Orbai, A., Alarcón, G. S., Gordon, C., Merrill, J. T., Fortin, P. R., Bruce, I. N., Isenberg, D., Wallace, D. J., Nived, O., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34473 · Cited by 5,322
Systemic Lupus Erythematosus
Tsokos, G. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37754-6.50094-4 · Cited by 3,990
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923

Flagged first, then by citations

Show all 144 references

Sorted by citations

Items 101–200 of 219

The role of autoantibodies in bridging obesity, aging, and immunosenescence
Valentino, T. R., Chen, N., Makhijani, P., Khan, S. M., Winer, S., Revelo, X. S., & Winer, D. A. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00489-2 · Cited by 27
Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation
Godavarthy, A., Kelly, R., Jimah, J. R., Beckford, M., Caza, T. N., Fernández, D., Huang, N., Duarte, M., Lewis, J., Fadel, H. J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.134010 · Cited by 25
Self-citation
Rapamycin alleviates renal damage in mice with systemic lupus erythematosus through improving immune response and function
Song, X., Gao, J., Liu, H., Liu, X.-H., & Tang, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111289 · Cited by 25
Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats
Luck, C., DeMarco, V. G., Mahmood, A., Gavini, M. P., & Pulakat, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5724046 · Cited by 25
The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions
Moskalev, A., Shaposhnikov, M. V., Proshkina, E., Belyi, A., Fedintsev, A., Zhikrivetskaya, S. O., Guvatova, Z. G., Садритдинова, А. Ф., Snezhkina, A., Krasnov, G. S., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-3356-0 · Cited by 24
miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling
Li, Y., Sun, Y., Hao, R., Pin, W., Zhang, L., Ma, X., Ma, Y., Wang, P., Xie, N., Xie, S., et al. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4276 · Cited by 24
The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus
Ren, J., Panther, E. J., Liao, X., Grammer, A. C., Lipsky, P. E., & Reilly, C. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124007 · Cited by 25
Aberrant expression of microRNA-99a and its target gene mTOR associated with malignant progression and poor prognosis in patients with osteosarcoma
Zhao, J., Chen, F., Zhou, Q., Pan, W., Wang, X., Xu, J., Li, N., & Yang, H. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s102421 · Cited by 23
Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element‐binding protein‐1 signaling
Chang, S., Huang, K., Cheng, C., Su, Y., Lee, K., Chen, C., & Chang, H. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25869 · Cited by 23
mTOR inhibitor INK128 attenuates systemic lupus erythematosus by regulating inflammation-induced CD11b+Gr1+ cells
Shi, G., Li, D., Li, X., Ren, J., Xu, J., Ding, L., Dou, H., & Hou, Y. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.007 · Cited by 22
Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway
Chen, X., Jiang, X., Cheng, C., Chen, J., Huang, S., Xu, M., & Liu, S. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06977-z · Cited by 22
The interplay between HPIP and casein kinase 1α promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway
Mai, H., Xu, X., Mei, G., Hong, T., Huang, J., Wang, T., Yan, Z., Li, Y., Liang, Y., Li, L., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.44 · Cited by 21
Interplay Between mTOR and Hippo Signaling in the Ovary: Clinical Choice Guidance Between Different Gonadotropin Preparations for Better IVF
Papageorgiou, K., Mastora, E., Zikopoulos, A., Grigoriou, M. E., Georgiou, I. A., & Michaelidis, T. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.702446 · Cited by 21
Redox Homeostasis Involvement in the Pharmacological Effects of Metformin in Systemic Lupus Erythematosus
Teng, X., Brown, J., & Morel, L. M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0070 · Cited by 21
Vitamin D3 affects browning of white adipocytes by regulating autophagy via PI3K/Akt/mTOR/p53 signaling in vitro and in vivo
Zhao, Y., & Qin, R. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01765-6 · Cited by 21
Stomatitis associated with mammalian target of rapamycin inhibition
Chambers, M. S., Rugo, H. S., Litton, J. K., & Meiller, T. F. (2018) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2017.10.024 · Cited by 21
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer
Wang, G., Dai, S., Chen, J., Zhang, K., Huang, C., Zhang, J., Xie, K., Lin, F., Wang, H., Gao, Y., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01426-y · Cited by 24
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway
Luo, J., Luo, X., Liu, X., Fang, Z., Xu, J., & Li, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s239407 · Cited by 20
Sirolimus therapy restores the PD-1+ICOS+Tfh:CD45RA-Foxp3high activated Tfr cell balance in primary Sjögren’s syndrome
Wang, Y., Guo, H., Liang, Z., Feng, M., Wu, Y., Qin, Y., Zhao, X., Gao, C., Liu, G., & Luo, J. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.04.006 · Cited by 21
Deciphering Obesity-Related Gene Clusters Unearths SOCS3 Immune Infiltrates and 5mC/m6A Modifiers in Ossification of Ligamentum Flavum Pathogenesis
Zhang, B., Yuan, L., Chen, G., Chen, X., Yang, X., Fan, T., Sun, C., Fan, D., & Chen, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.861567 · Cited by 19
RNA ‐binding proteins in autoimmunity: From genetics to molecular biology
Lodde, V., Floris, M., Zoroddu, E., Zarbo, I. R., & Idda, M. L. (2023) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1772 · Cited by 19
Systemic lupus erythematosus-myasthenia gravis overlap syndrome: Presentation and treatment depend on prior thymectomy
Minchenberg, S. B., Chaparala, G., Oaks, Z., Bánki, K., & Perl, A. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.07.007 · Cited by 19
Self-citation
UCHL1 aggravates skin fibrosis through an IGF ‐1‐induced Akt/ mTOR / HIF ‐1α pathway in keloid
Guo, C., Liang, L., Zheng, J.-B., Xie, Y., Qiu, X., Tan, G., Huang, J., & Wang, L. (2023) · The FASEB Journal · doi:10.1096/fj.202300153rr · Cited by 18
Hypoxia induced responses are reflected in the stromal proteome of breast cancer
Kjølle, S., Finne, K., Birkeland, E., Ardawatia, V. V., Winge, I., Aziz, S. M., Knutsvik, G., Wik, E., Paulo, J. A., Vethe, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39287-7 · Cited by 18
Rapamycin Added to Diet in Late Mid-Life Delays Age-Related Hearing Loss in UMHET4 Mice
Altschuler, R. A., Kabara, L. L., Martin, C., Kanicki, A. C., Stewart, C. E., Kohrman, D. C., & Dolan, D. F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.658972 · Cited by 22
Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer
Guo, H., Zhong, Y., Jackson, A. L., Clark, L. H., Kilgore, J., Zhang, L., Han, J., Sheng, X., Gilliam, T. P., Gehrig, P. A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7934 · Cited by 18
Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea
Altschuler, R. A., Kanicki, A. C., Martin, C., Kohrman, D. C., & Miller, R. A. (2018) · Hearing Research · doi:10.1016/j.heares.2018.09.003 · Cited by 20
An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch
Aronoff, J. E., & Trumble, B. C. (2025) · Evolution Medicine and Public Health · doi:10.1093/emph/eoaf010 · Cited by 17
The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice
Qiu, Z., Zhang, S., Li, A., Yu, J., Li, N., Huang, F., & Liu, B. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.035 · Cited by 16
Association of Oxidative Stress with Disease Activity and Damage in Systemic Lupus Erythematosus: A Cross Sectional Study from a Tertiary Care Centre in Southern India
Shruthi, S., Thabah, M. M., Bobby, Z., & Negi, V. S. (2020) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-020-00879-5 · Cited by 16
Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis
Fan, Y., Ma, K., Lin, Y., Ren, J., Peng, H., Yuan, L., Nasser, M. I., Jiang, X., & Wang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1520570 · Cited by 16
Role of the mTOR signalling pathway in salivary gland development
Sakai, M., Fukumoto, M., Ikai, K., Minagi, H. O., Inagaki, S., Kogo, M., & Sakai, T. (2019) · FEBS Journal · doi:10.1111/febs.14937 · Cited by 15
Azithromycin modulates Teff/Treg balance in retinal inflammation via the mTOR signaling pathway
Huang, J. C., Li, Z., Hu, Y., Chen, G., Li, Z., Xie, Y., Huang, H., Su, W., Chen, X., & Liang, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114793 · Cited by 15
Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth
Patra, T., Bose, S. K., Kwon, Y., Meyer, K., & Ray, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118764 · Cited by 16
Older Human B Cells and Antibodies
Dunn‐Walters, D. K., & O’Hare, J. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_21-1 · Cited by 14
Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway
Geng, S., Wen, J., Shen, C., Liu, L.-Z., Jiang, Y., Fu, J., Guan, Y., Ye, Z., Wu, Y., Li, C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1567193 · Cited by 14
Proteodynamics and aging of eukaryotic cells
Witkowski, J. M., Bryl, E., & Fülöp, T. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111430 · Cited by 14
Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics
Hua, Y., Xie, D., Zhang, Y., Wang, M., Wen, W., & Sun, J. M. (2023) · Gene · doi:10.1016/j.gene.2023.147755 · Cited by 13
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
Mota‐Martorell, N., Jové, M., & Pamplona, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158747 · Cited by 13
mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation.
André, C., Catania, C., Rémus-Borel, J., Ladevèze, E., Leste-Lasserre, T., Mazier, W., Binder, E., Gonzales, D., Clark, S., Guzmán-Quevedo, O., et al. (2018) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2018.03.014 · Cited by 11
mTOR-dependent autophagy contributes to end-organ resistance and serves as target for treatment in autoimmune disease
Perl, A. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.033 · Cited by 13
Self-citation
Autoimmune Hepatitis and Stellate Cells: An Insight into the Role of Autophagy
Golbabapour, S., Lankarani, K. B., Ghavami, S., & Geramizadeh, B. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190402120231 · Cited by 13
Context-Specific Function of S6K2 in Th Cell Differentiation
Pai, C., Walsh, C. M., & Fruman, D. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600167 · Cited by 12
Identification and clinical validation of key genes as the potential biomarkers in colorectal adenoma
Wang, B., Zhang, J., Wang, X., Zhao, L., Wang, Y., Fan, Z., Liu, L., & Gao, W. (2023) · BMC Cancer · doi:10.1186/s12885-022-10422-9 · Cited by 12
Metformin displays in vitro and in vivo antitumor effect against osteosarcoma
Ko, Y., Choi, A., Lee, M., & Lee, J. A. (2016) · Korean Journal of Pediatrics · doi:10.3345/kjp.2016.59.9.374 · Cited by 13
T cell aging and exhaustion: Mechanisms and clinical implications
Zhang, W., Kong, D., Zhang, X., Hu, L., Nian, Y., & Shen, Z. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110486 · Cited by 13
Pan-Cancer Analysis Reveals Alternative Splicing Characteristics Associated With Immune-Related Adverse Events Elicited by Checkpoint Immunotherapy
He, X., Yu, J., & Shi, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797852 · Cited by 11
The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in patients with rheumatic disorders during glucocorticoid treatment
Yoshikawa, N., Shimizu, N., Uehara, M., Oda, A., Matsumiya, R., Matsubara, E., Kobayashi, H., Hosono, O., Souta-Kuribara, A., Baba, H., et al. (2016) · Modern Rheumatology · doi:10.1080/14397595.2016.1213480 · Cited by 11
Role of the mTOR‑FOXO1 pathway in obesity‑associated renal tubulointerstitial inflammation
Sun, H. Q., Shao, X., He, J., Golos, M., & Shi, B. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9727 · Cited by 11
Decreased Expression of Urinary Mammalian Target of Rapamycin mRNA Is Related to Chronic Renal Fibrosis in IgAN
Cao, Y., Wang, Y., Liu, Y., Zhu, X., Zhang, G., Wang, S., Chen, X., Liu, D., & Fu, C. (2019) · Disease Markers · doi:10.1155/2019/2424751 · Cited by 10
The dual role of mTOR signaling in lung development and adult lung diseases
Bao, J., Bao, W., Song, Y., Li, Z., Kan, L., Fu, J., & Zhang, D. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01428-4 · Cited by 10
Signaling pathways shaping the field of lipidomics
Ahi, E. P., & House, A. H. (2025) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2025.107053 · Cited by 9
Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway
Sorice, M., Profumo, E., Capozzi, A., Recalchi, S., Riitano, G., Veroli, B. D., Saso, L., & Buttari, B. (2023) · Biomolecules · doi:10.3390/biom13081221 · Cited by 10
Immunologic Effects of Sirolimus in Patients With Vascular Anomalies
Nozawa, A., Ozeki, M., Yasue, S., Endo, S., Kawamoto, N., Ohnishi, H., Fumino, S., Furukawa, T., Tajiri, T., Maekawa, T., et al. (2019) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000001650 · Cited by 8
Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity
Föh, B., Buhre, J. S., Sina, C., & Ehlers, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004644 · Cited by 7
Integrated analysis identifies a novel lncRNA prognostic signature associated with aerobic glycolysis and hub pathways in breast cancer
Li, Z., Zheng, J., Feng, Y., Li, Y., Liang, Y., Liu, Y., Wang, X., & Yang, Q. (2021) · Cancer Medicine · doi:10.1002/cam4.4291 · Cited by 8
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
Park, H.-W., Lee, S.-Y., & Lee, H. S. (2025) · Inflammation Research · doi:10.1007/s00011-025-01992-y · Cited by 7
Protocadherin gamma C3: a new player in regulating vascular barrier function
Burek, M., Kaupp, V., Blecharz-Lang, K. G., Dilling, C., & Meybohm, P. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.343896 · Cited by 7
The Bidirectional Role of Obesity and Aging in the Pathogenesis of Osteoarthritis: Molecular Mechanisms, Epigenetic Insights, and Therapeutic Implications
Lin, C., Yang, J., Su, H., Zhang, X., & Wang, B. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s514521 · Cited by 7
Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice
Queiroz, L. A. D., de Barros, R. S., de Assis, J. B., Silva, C. C. C., Turato, W. M., Bustia, S. X., Rodrigues, S. F., Sá‐Nunes, A., & Martins, J. O. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682406 · Cited by 6
Metabolic Modulators in Cardiovascular Complications of Systemic Lupus Erythematosus
Miñano, S., González‐Correa, C., Moleón, J., & Duarte, J. (2023) · Biomedicines · doi:10.3390/biomedicines11123142 · Cited by 6
Genetic Variants Within MTORC1 Genes Predict Gastric Cancer Prognosis in Chinese Populations
Xue, W., Wang, M., Zhang, L., Gu, J. H., Zhu, X., Wang, Y., Wang, R., Wang, L., Wang, W., Wang, X., et al. (2018) · Journal of Cancer · doi:10.7150/jca.23566 · Cited by 6
Distinct CD4+ T cell signature in ANA-positive young adult patients
Zotti, F. D., Moriconi, C., Qiu, A., Miller, A., & Hudson, K. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.972127 · Cited by 5
Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function
Qian, T., Huo, B., Deng, X., Song, X., Jiang, Y., Yang, J., & Hao, F. (2023) · International Immunology · doi:10.1093/intimm/dxad027 · Cited by 5
Activation of the mTOR dependent signaling pathway underlies ketamine‐induced uropathy
Lin, C., Yang, A., & Lin, A. T. (2017) · Neurourology and Urodynamics · doi:10.1002/nau.23234 · Cited by 6
Phytochemical modulation of mTOR signaling: emerging nanotechnology-driven therapeutics for rheumatoid arthritis management
Mandlik, D. S., Adgaonkar, P., & Mandlik, S. K. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01844-5 · Cited by 5
PPAR-γ Signaling and Common Protective Pathways against Obesity and Alzheimer's Disease
SHARMA, A. K., Devi, S., Mannan, A., Kumar, M., & Singh, T. G. (2024) · Current Signal Transduction Therapy · doi:10.2174/0115743624267214241016103515 · Cited by 4
Rapamycin relieves lupus nephritis by regulating TIM-3 and CD4+CD25+Foxp3+ Treg cells in an MRL/lpr mouse model
Gao, Y., Fan, X.-Z., Li, R., & Zhou, X. (2022) · Central European Journal of Immunology · doi:10.5114/ceji.2022.118778 · Cited by 4
Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells
Kucińska, M., Piotrowska‐Kempisty, H., Lisiak, N., Kaczmarek, M., Dams‐Kozlowska, H., Granig, W. H., Höferl, M., Jäger, W. R., Zehl, M., Murias, M., et al. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2016.09.017 · Cited by 4
The final gate: bacterial subversion of autophagosome-lysosome fusion as a conserved immune evasion strategy
Chowdhury, I. J. K., Siregar, T. A. P., Haque, M. F., & Ponpuak, M. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2562930 · Cited by 4
Small-molecule mTOR inhibitors in the clinic: From bench to bedside
Chen, Y., Sun, X., Yu, Z., Liu, D., & Hu, R. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109048 · Cited by 3
Metabolic control of pathogenesis in autoimmune diseases
Perl, A., & Morel, L. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00059-x · Cited by 3
Self-citation
Cell Injury and Necrosis
d’Avila, J. C., Levin, S., & Radi, Z. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64220-4 · Cited by 3
Maternal pre‐pregnancy body mass index and offspring with overweight/obesity at preschool age: The possible role of epigenome‐wide DNA methylation changes in cord blood
Chang, R., Zhang, Y., Sun, J., Xu, K., Li, C., Zhang, J., Mei, W., Zhang, H., & Zhang, J. (2022) · Pediatric Obesity · doi:10.1111/ijpo.12969 · Cited by 3
Composition and Functional Capacity of Gut Microbes are Associated with Arterial Stiffness: A Prospective Study
Li, J., Zhong, Y., Bai, J., Chen, S., Cai, J., Wu, S., & Zhang, W. (2023) · Cardiology Discovery · doi:10.1097/cd9.0000000000000085 · Cited by 3
Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation
Madrakhimov, S. B., Yang, J. Y., Park, H. Y., & Park, T. K. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2692-5 · Cited by 3
The db mutation improves memory in younger mice in a model of Alzheimer's disease
Zhang, L., Fernandez-Kim, S.-O., Beckett, T. L., Niedowicz, D. M., Köhler, K., Dasuri, K., Bruce‐Keller, A. J., Murphy, M. P., & Keller, J. N. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.013 · Cited by 3
Association between glomerular mTORC1 activation and crescents formation in lupus nephritis patients
Ding, Y., Luan, Z.-Q., Mao, Z., Qu, Z., & Yu, F. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109288 · Cited by 2
Cellular cholesterol metabolism rewiring through SREBP2-LXR-mTOR signaling convergence orchestrates T cell fate and keratinocyte apoptosis in oral lichen planus
Jiang, Q. L., Tang, Y.-X., & Zhou, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115457 · Cited by 2
Podocyte, tubular epithelial-immune cell interplay in the pathogenesis of lupus nephritis
Chen, J., Chen, Z.-X., Mou, X., Rui, K., & Tian, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682075 · Cited by 3
Protective and multi-organ effects of MOTS-c and other mitochondrial-derived peptides in the endocrine system
Kamiński, K., Szyszka, M., Blatkiewicz, M., & Ruciński, M. (2023) · Medical Journal of Cell Biology · doi:10.2478/acb-2023-0017 · Cited by 2
Cancer Biology: Severe Cumulative Delayed Type Hypersensitivity Reactions
Khatami, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-66475-0_6 · Cited by 2
The human erythrocyte can become both a metabolic “Achilles’ Heel” and a “Trojan Horse”: Likely consequences of persistent excessive glycolysis
Hipkiss, A. R. (2019) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000244 · Cited by 2
Metabolic and mitochondrial dysfunction in SLE
Perl, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820583-9.00014-2 · Cited by 2
Self-citation
Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis
Simonovich, J. A., Macias, S. L., Zhou, M., Portelli, M., Verma, I., Wanchoo, A., Kwiatkowski, A. J., Helm, E. Y., Ngo, T. B., Islam, S., et al. (2025) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00040-y · Cited by 1
Psychoneuroimmunology of Aging
Yan, Q. (2016) · Springer eBooks · doi:10.1007/978-3-319-45111-4_9 · Cited by 1
Noninvasive Analysis Using Data‐Independent Acquisition Mass Spectrometry: New Epidermal Proteins That Reveal Sex Differences in the Aging Process
Chen, S., Zhang, H., Liu, M., Wang, Y., Xin, C., Ma, J., Zheng, X., Zhang, X., Sun, L., & Yang, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8849328 · Cited by 1
Twin and family studies on epigenetics of autoimmune diseases
Jokkel, Z., Piroska, M., Szalontai, L., Hernyes, A., Tárnoki, D. L., & Tárnoki, Á. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820951-6.00009-0 · Cited by 1
BMI ‐dependent prognostic role of EEF1G in breast cancer: A 15‐year follow‐up of the Guangzhou Breast Cancer Cohort Study
Li, N., Xiao, C., Han, S., Lu, M., Chen, Q., Yang, Y., Tang, L., Ren, Z., & Xu, L. (2025) · Cancer Medicine · doi:10.1002/cam4.70227 · Cited by 1
Type 2 diabetes mellitus, drug addiction, bipolar disorder and epilepsy display overlapping aetiopathogenic mechanisms: Implication for prevention and pharmacotherapy
Oriaifo, S. E. (2015) · International Research Journal of Medicine and Medical Sciences · doi:10.14303/jmms.2015.116 · Cited by 1
Autophagy: A new insight into pathogenesis and treatment possibilities in age-related macular degeneration
Kubicka‐Trząska, A., Karska‐Basta, I., & Żuber-Łaskawiec, K. (2020) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.2495 · Cited by 1
Evaluating the value of p70s6k and mTOR signaling pathway in monitoring exercise-induced central fatigue in rats
He, G., Jiang, H., Zhang, E., Wan, P., Liu, G., & Ji, Z. (2022) · Cellular and Molecular Biology · doi:10.14715/cmb/2022.68.10.12 · Cited by 1
High-carbohydrate, High-fat Diet-induced Hyperlipidemia Hampers the Differentiation Balance of Bone Marrow Mesenchymal Stem Cells by Suppressing Autophagy via the AMPK/ mTOR Pathway in Rat ModelsPreprint
Shang, Z., Zhang, T., Jiang, M., Yin, X., Sun, H. Q., & Liang, X. (2020) · doi:10.21203/rs.3.rs-42244/v1 · Cited by 1
Translational Control and mTOR in Cancer
Seeböck, R., Golob‐Schwarzl, N., & Krassnig, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-53659-0_5
Chronic mTOR Inhibition by Rapamycin and Diabetes
Yan, L., & Cai, Z. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00009-8
An Insight on Selective Signaling Pathways Linking Obesity and Cancer
Akshayavardhani, A., & Pratheesh, P. (2018) · SBV Journal of Basic Clinical and Applied Health Science · doi:10.5005/jp-journals-10082-01124
Tissue Damage in Lupus
Oates, J. C., & Nowling, T. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47927-1.00018-9
Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host DiseasePreprint
Park, G., Kim, D., Huuhtanen, J., Lundgren, S., Khajuria, R. K., Hurtado, A. M., Muñoz‐Calleja, C., Cardeñoso, L., de Soria, V. G.-G., Chen‐Liang, T. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/747196
Activación de vías redox en respuesta a cargas únicas de ejercicio
Espinoza, B. L. A., Legleu, C. E. C., González-Rodríguez, E., & Reza‐López, S. A. (2020) · Revista de Ciencias del Ejercicio FOD · doi:10.29105/rcefod15.1-26
The sequential role of Mst1/mTORC1/STAT1 activity in chemokine receptor 2-regulated B cell receptor signalingPreprint
Zhu, Y., Gu, H., Yang, L., Li, N., Chen, Q., Kang, D., Jing, Y., Jiang, P., Chen, Q., Luo, L., et al. (2021) · doi:10.22541/au.161540733.35848371/v1

Authors: Perl, A.
Affiliations: Division of Rheumatology, Department of Medicine State University of New York, Upstate Medical University College of Medicine Syracuse New York
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2015-04-23
Volume: 1346
Issue: 1
Pages: 33-44
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.12756
PMC: PMC4480196
OpenAlex: W1749413658
Cited by: 218
References: 144
Citations by year: 2026: 7 · 2025: 16 · 2024: 9 · 2023: 16 · 2022: 18 · 2021: 26 · 2020: 20 · 2019: 29 · 2018: 31 · 2017: 20 · 2016: 21 · 2015: 5
FWCI: 2.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (AI 048079, AI 072648)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mTOR, mTORC1, mTORC2, rapamycin, mTOR inhibitors, autoimmune disease, systemic lupus erythematosus, cancer, obesity, aging, Warburg effect, hypoxia, oxidative stress, autophagy, mRNA translation, biomarkers
MeSH terms: Aging, Animals, Autoimmune Diseases, Humans, Neoplasms, Obesity, Signal Transduction, Biomarkers, Sirolimus, Precision Medicine, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks