The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Resveratrol for Alzheimer's disease
Open accessAbstract
The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's disease (AD). Thus, targeting molecular mechanisms of aging may be a viable treatment approach. Caloric restriction prevents diseases of aging, including AD, in animal models, perhaps by activation of sirtuins. The sirtuins (e.g., mammalian SIRT1) are deacetylases that link energy balance (NAD+/NADH) to regulation of gene transcription. Resveratrol is a potent activator of SIRT1, and thus may mimic caloric restriction to prevent diseases of aging. We conducted a randomized, double‐blind, placebo‐controlled, phase II trial of resveratrol for individuals with mild‐to‐moderate AD. Resveratrol (1) is detectable in cerebrospinal fluid (at low nanomolar levels), (2) is safe and well tolerated, (3) alters AD biomarker trajectories, (4) preserves blood–brain barrier integrity, and (5) modulates the CNS immune response. Further studies are needed to determine the safety and efficacy of resveratrol and the validity of this approach in the treatment and prevention of AD and other diseases of aging.
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Cited by
Emerging roles of oxidative stress in brain aging and Alzheimer's disease
Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737
Aging and age‐related diseases: from mechanisms to therapeutic strategies
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Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
(2018) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 455
Effect of resveratrol and pterostilbene on aging and longevity
Li, Y., Li, S., & Lin, C. (2018) · BioFactors · doi:10.1002/biof.1400 · Cited by 346
Resveratrol and Its Effects on the Vascular System
Breuss, J. M., Atanasov, A. G., & Uhrin, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071523 · Cited by 328
Metadata
- Authors
- Sawda, C., Moussa, C., & Turner, R. S.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2017-08-16
- Volume
- 1403
- Issue
- 1
- Pages
- 142-149
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2747751876
- Cited by
- 276
- References
- 18
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- green
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