Role of myofibroblasts in normal and pathological periodontal wound healing
Abstract
Myofibroblasts represent specific subpopulations of cells with important roles in tissue remodeling in both health and disease. They are not usually found in resting healthy tissues. However, they increase in number during the proliferative phase of wound healing. In these conditions, myofibroblasts secrete and organize different molecular components of the extracellular matrix that with time will reconstitute and hopefully regenerate the damaged tissue. Importantly, these cell populations must be eliminated after wound healing has been completed. However, deficiencies in their differentiation or the persistence of this cell population has been associated with the development of delayed wound healing and fibrosis, respectively. In the present review, we analyze the involvement of myofibroblasts in periodontal wound healing and their potential contribution to tissue homeostasis and disease.
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PDGF has a direct effect by increasing expression of COX-2.
“Apart from the indirect effect of PDGF, there is a direct effect by increasing the expression of COX-2 which has been proven in some studies [59, 60].”
From An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth (2019) · cites this paper as [60]
Cites
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
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Inflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415 · see citing works
Serini, G., Bochaton-Piallat, M.-L., Ropraz, P., Geinoz, A., Borsi, L., Zardi, L., & Gabbiani, G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.3.873 · Cited by 847 · see citing works
The role of myofibroblasts in wound healing
Hinz, B. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.09.003 · Cited by 328 · see citing works
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An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth
Farook, F. F., M. Nizam, M. N., & Alshammari, A. (2019) · The Open Dentistry Journal · doi:10.2174/1874210601913010430 · Cited by 18 · see citing works
- Authors
- Smith, P.
- Affiliations
- School of Dentistry Faculty of Medicine Pontificia Universidad Católica de Chile Santiago Chile
- ORCID
- Smith, PC
- Venue
- Oral Diseases
- Publisher
- Wiley
- Published
- 2018-02-26
- Volume
- 24
- Issue
- 1-2
- Pages
- 26-29
- ISSN
- 1354-523X (ISSN-L)
- 1601-0825
- OpenAlex
- W2793140478
- Cited by
- 14
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico (1170555)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- myofibroblasts, periodontal healing, extracellular matrix, tissue remodeling, fibrosis, delayed wound healing, tissue homeostasis, periodontal disease
- MeSH terms
- Homeostasis, Humans, Wound Healing, Gingival Overgrowth, Myofibroblasts
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