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Neutrophils direct preexisting matrix to initiate repair in damaged tissues

Fischer, A., Wannemacher, J., Christ, S., Koopmans, T., Kadri, S., Zhao, J., Gouda, M., Ye, H., Mück-Häusl, M., Krenn, P. W., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01166-6 · Cited by 114 · see citing works

Molecular Pathophysiology of Chronic Wounds: Current State and Future DirectionsPreprint

Pastar, I., Balukoff, N. C., Marjanović, J., Chen, V. Y., Stone, R. C., & Tomic‐Canic, M. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041243 · Cited by 122 · see citing works

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Riha, S. M., Maarof, M., & Fauzi, M. B. (2021) · Polymers · doi:10.3390/polym13101546 · Cited by 110 · see citing works

Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review

Viganò, P., Ottolina, J., Bartiromo, L., Bonavina, G., Schimberni, M., Villanacci, R., & Candiani, M. (2019) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2019.11.011 · Cited by 109 · see citing works

Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing

Jiang, D., & Scharffetter‐­Kochanek, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00697 · Cited by 107 · see citing works

Human keratinocyte-derived microvesicle miRNA-21 promotes skin wound healing in diabetic rats through facilitating fibroblast function and angiogenesis

Li, Q., Zhao, H., Chen, W., Huang, P., & Bi, J. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105570 · Cited by 101 · see citing works

Chronic Wound Healing Models

Flynn, K., Mahmoud, N. N., Sharifi, S., Gould, L. J., & Mahmoudi, M. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00030 · Cited by 101 · see citing works

The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling

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Development of photosynthetic sutures for the local delivery of oxygen and recombinant growth factors in wounds

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Living Electrospun Short Fibrous Sponge via Engineered Nanofat for Wound Healing

Fu, X., Wang, J., Qian, D., Chen, Z., Chen, L., Cui, W., & Wang, Y. (2022) · Advanced Fiber Materials · doi:10.1007/s42765-022-00229-5 · Cited by 89 · see citing works

Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside

Ghonim, M. A., Boyd, D. F., Flerlage, T., & Thomas, P. G. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170499 · Cited by 87 · see citing works

Current Therapeutic Approach to Hypertrophic Scars

Mokoš, Z. B., Balić, A., Grgurević, L., Dumić-Čule, I., Kostović, K., Čeović, R., & Marinović, B. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00083 · Cited by 87 · see citing works

Regulatory T cells in skin regeneration and wound healing

Knoedler, S. A., Knoedler, L., Kauke‐Navarro, M., Rinkevich, Y., Hundeshagen, G., Harhaus, L., Kneser, U., Pomahač, B., Orgill, D. P., & Panayi, A. C. (2023) · Military Medical Research · doi:10.1186/s40779-023-00484-6 · Cited by 89 · see citing works

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Jiang, X., Zeng, Y., Li, C., Wang, K., & Yu, D. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1354286 · Cited by 85 · see citing works

Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease

Khalili‐Tanha, G., Radisky, E. S., Radisky, D. C., & Shoari, A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06447-w · Cited by 90 · see citing works

PROLIDASE: A Review from Discovery to its Role in Health and Disease

Eni-Aganga, I., Lanaghan, Z. M., Balasubramaniam, M., Dash, C., & Pandhare, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.723003 · Cited by 85 · see citing works

Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

Wietecha, M. S., Pensalfini, M., Cangkrama, M., Mueller, B., Jin, J., Brinckmann, J., Mazza, E., & Werner, S. (2020) · Nature Communications · doi:10.1038/s41467-020-16409-z · Cited by 82 · see citing works

Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation

Feng, Y., Wu, J., Sun, Z., Liu, S., Zou, M., Yuan, Z., Yu, S., Lv, G., & Yuan, F. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102715 · Cited by 79 · see citing works

Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms

Ahangar, P., Mills, S. J., Smith, L. E., Gronthos, S., & Cowin, A. J. (2020) · npj Regenerative Medicine · doi:10.1038/s41536-020-00109-9 · Cited by 79 · see citing works

IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation

Li, S., Ding, X., Zhang, H., Ding, Y., & Tan, Q. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108605 · Cited by 79 · see citing works

Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection

Hiebert, P., & Werner, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163856 · Cited by 78 · see citing works

Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology

Guo, S. (2022) · Reproduction · doi:10.1530/rep-22-0224 · Cited by 79 · see citing works

Diversity of Fibroblasts and Their Roles in Wound HealingPreprint

Jiang, D., Guo, R., Machens, H., & Rinkevich, Y. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041222 · Cited by 76 · see citing works

Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds

Wlaschek, M., Singh, K., Sindrilaru, A., Crisan, D., & Scharffetter-Kochanek, K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.036 · Cited by 76 · see citing works

Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis

Blander, H. D., Morel, A., Senaratne, A. P., Ouzounova, M., & Puisieux, A. (2021) · Cancers · doi:10.3390/cancers13184561 · Cited by 74 · see citing works

Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing

Arndt, S., Schmidt, A., Karrer, S., & von Woedtke, T. (2018) · Clinical Plasma Medicine · doi:10.1016/j.cpme.2018.01.002 · Cited by 72 · see citing works

Application of ADSCs and their Exosomes in Scar Prevention

Li, C., Wei, S., Xu, Q., Sun, Y., Ning, X., & Wang, Z. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10252-5 · Cited by 75 · see citing works

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing

Piperigkou, Z., Götte, M., Theocharis, A. D., & Karamanos, N. K. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.008 · Cited by 71 · see citing works

Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes

ten Brink, T., Damanik, F., Rotmans, J. I., & Moroni, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202301939 · Cited by 71 · see citing works

Induced Pluripotent Stem Cell-Derived Smooth Muscle Cells Increase Angiogenesis and Accelerate Diabetic Wound Healing

Gorecka, J., Gao, X., Fereydooni, A., Dash, B. C., Luo, J., Lee, S.-R., Taniguchi, R., Hsia, H. C., Qyang, Y., & Dardik, A. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0086 · Cited by 66 · see citing works

Intracellular signaling dynamics and their role in coordinating tissue repair

Ghilardi, S. J., O’Reilly, B. M., & Sgro, A. E. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1479 · Cited by 65 · see citing works

Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing

Zou, M., Teng, Y., Wu, J., Liu, S., Tang, X., Jia, Y., Chen, Z.-H., Zhang, K., Sun, Z., Li, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.713605 · Cited by 65 · see citing works

Immunomodulatory Nanosystems: Advanced Delivery Tools for Treating Chronic Wounds

Chu, X., Xiong, Y., Knoedler, S. A., Lü, L., Panayi, A. C., Alfertshofer, M. G., Jiang, D., Rinkevich, Y., Lin, Z., Zhao, Z., et al. (2023) · Research · doi:10.34133/research.0198 · Cited by 65 · see citing works

Wound healing: insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation

Lacina, L., Kolář, M., Pfeiferová, L., Gál, P., & Smetana, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403570 · Cited by 65 · see citing works

Epigenetic regulation of cellular functions in wound healing

Pastar, I., Marjanović, J., Stone, R. C., Chen, V., Burgess, J. L., Mervis, J. S., & Tomic‐Canic, M. (2021) · Experimental Dermatology · doi:10.1111/exd.14325 · Cited by 60 · see citing works

A gerophysiology perspective on healthy ageing

Kémoun, P., Ader, I., Planat‐Benard, V., Dray, C., Fazilleau, N., Monsarrat, P., Cousin, B., Paupert, J., Ousset, M., Lorsignol, A., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101537 · Cited by 60 · see citing works

Biological approaches for hypertrophic scars

Zhong, L.-Z., Li, M.-R., & Fu, X.-B. (2019) · International Wound Journal · doi:10.1111/iwj.13286 · Cited by 50 · see citing works

In vitro , in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss

Chernyavsky, I. L., RUSSELL, R. J., Saunders, R. M., Morris, G. E., Berair, R., Singapuri, A., Chachi, L., Mansur, A. H., Howarth, P. H., Dennison, P. W., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01680-2017 · Cited by 57 · see citing works

Dermal Fibroblast Heterogeneity and Its Contribution to the Skin Repair and Regeneration

Xue, M., Zhao, R., MARCH, L. M., & Jackson, C. (2021) · Advances in Wound Care · doi:10.1089/wound.2020.1287 · Cited by 55 · see citing works

Granulation tissue myofibroblasts during normal and pathological skin healing: The interaction between their secretome and the microenvironment

Arif, S., Attiogbe, E., & Moulin, V. J. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12919 · Cited by 55 · see citing works

Fibroblasts in Diabetic Foot Ulcers

Voza, F. A., Huerta, C. T., Le, N., Shao, H., Ribieras, A. J., Ortiz, Y. Y., Atkinson, C., Machuca, T., Liu, Z., & Velazquez, O. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042172 · Cited by 55 · see citing works

Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †

Chellini, F., Tani, A., Vallone, L., Nosi, D., Pavan, P., Bambi, F., Orlandini, S. Z., & Sassoli, C. (2018) · Cells · doi:10.3390/cells7090142 · Cited by 53 · see citing works

The role of lipid-based signalling in wound healing and senescence

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Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions

Jenkins, B. H., Buckingham, J. F., Hanley, C. J., & Thomas, G. J. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108231 · Cited by 52 · see citing works

The effects of mechanical force on fibroblast behavior in cutaneous injury

Berry, C. E., Downer, M. A., Morgan, A. G., Griffin, M., Liang, N. E., Kameni, L. E., Parker, J. B. L., Guo, J. L., Longaker, M. T., & Wan, D. C. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1167067 · Cited by 53 · see citing works

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts

Kühl, T., & Lagares, D. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.020 · Cited by 49 · see citing works

Understanding Drivers of Ocular Fibrosis: Current and Future Therapeutic Perspectives

Mallone, F., Costi, R., Marenco, M., Plateroti, R., Minni, A., Attanasio, G., Artico, M., & Lambìase, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111748 · Cited by 49 · see citing works

Activation of mTORC1 in fibroblasts accelerates wound healing and induces fibrosis in mice

Hu, X., Zhang, H., Li, X., Li, Y., & Chen, Z. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12759 · Cited by 46 · see citing works

Bisphosphonate‐induced reactive oxygen species inhibit proliferation and migration of oral fibroblasts: A pathogenesis of bisphosphonate‐related osteonecrosis of the jaw

Taniguchi, N., Osaki, M., Onuma, K., Ishikawa, M., Ryoke, K., Kodani, I., & Okada, F. (2019) · Journal of Periodontology · doi:10.1002/jper.19-0385 · Cited by 46 · see citing works

Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds

Wan, L., Jiang, D., Correa‐Gallegos, D., Ramesh, P., Zhao, J., Ye, H., Zhu, S., Wannemacher, J., Volz, T., & Rinkevich, Y. (2021) · Matrix Biology · doi:10.1016/j.matbio.2021.01.005 · Cited by 46 · see citing works

The Role of the Fibronectin Synergy Site for Skin Wound Healing

Gimeno-LLuch, I., Benito-Jardón, M., Guerrero-Barberà, G., Burday, N., & Costell, M. (2022) · Cells · doi:10.3390/cells11132100 · Cited by 47 · see citing works

Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing

Song, J., Zhu, K., Wang, H., Wu, M., Wu, Y., & Zhang, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88461 · Cited by 45 · see citing works

Acceleration of chronic wound healing by bio-inorganic polyphosphate: In vitro studies and first clinical applications

Schepler, H., Neufurth, M., Wang, S., She, Z., Schröder, H. C., Wang, X., & Müller, W. E. G. (2021) · Theranostics · doi:10.7150/thno.67148 · Cited by 44 · see citing works

Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo

Knight, K. M., King, G. E., Palcsey, S. L., Suda, A., Liang, R., & Moalli, P. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.051 · Cited by 45 · see citing works

Allogeneic platelet‐rich plasma (PRP) is superior to platelets or plasma alone in stimulating fibroblast proliferation and migration, angiogenesis, and chemotaxis as relevant processes for wound healing

van der Bijl, I., Vlig, M., Middelkoop, E., & de Korte, D. (2019) · Transfusion · doi:10.1111/trf.15535 · Cited by 44 · see citing works

Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage

Eremichev, R. Y., Kulebyakina, M., Alexandrushkina, N. A., Nimiritsky, P., Basalova, N. A., Grigorieva, O., Egiazaryan, M., Dyikanov, D. T., Va, T., & Макаревич, П. И. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.616893 · Cited by 41 · see citing works

Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super‐Regenerator Vertebrates to Combat Scarring

Durant, F., & Whited, J. L. (2021) · Advanced Science · doi:10.1002/advs.202100407 · Cited by 41 · see citing works

Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming

Hoerst, K., van den Broek, L., Sachse, C., Klein, O., von Fritschen, U., Gibbs, S., & Hedtrich, S. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01772-2 · Cited by 41 · see citing works

Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice

Men, S., Huo, Q., Shi, L., Yan, Y., Yang, C., Yu, W. H., & Liu, B. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13042 · Cited by 41 · see citing works

CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF-mediated pathway that intersects with TGFβR/p38MAPK signaling in murine skin fibroblasts

Wang, Y., Mack, J. A., & Maytin, E. V. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007834 · Cited by 41 · see citing works

The Role of Airway Myofibroblasts in Asthma

Jendzjowsky, N. G., & Kelly, M. M. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.08.1917 · Cited by 41 · see citing works

Application of Electrospun Nanofiber Membrane in the Treatment of Diabetic Wounds

Gao, Z., Wang, Q., Yao, Q., & Zhang, P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010006 · Cited by 42 · see citing works

Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing

Latif, A., Fisher, L. E., Dundas, A. A., Crucitti, V. C., Imir, Z., Lawler, K., Pappalardo, F., Muir, B., Wildman, R., Irvine, D., et al. (2022) · Advances in Materials · doi:10.1002/adma.202208364 · Cited by 35 · see citing works

Gelatin–chitosan–cellulose nanocrystals as an acellular scaffold for wound healing application: fabrication, characterisation and cytocompatibility towards primary human skin cells

Cheah, Y. J., Yunus, M. H. M., Fauzi, M. B., Tabata, Y., Hiraoka, Y., Phang, S. J., Chia, M. R., Buyong, M. R., & Yazid, M. D. (2023) · Cellulose · doi:10.1007/s10570-023-05212-w · Cited by 38 · see citing works

A Preliminary Study for an Intraoperative 3D Bioprinting Treatment of Severe Burn Injuries

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Fibrosis in burns: an overview of mechanisms and therapies

Faour, S., Farahat, M., Aijaz, A., & Jeschke, M. G. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00254.2023 · Cited by 37 · see citing works

Emerging biomedical technologies for scarless wound healing

Cao, X., Wu, X., Zhang, Y., Qian, X., Sun, W., & Zhao, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.001 · Cited by 37 · see citing works

Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing

Ha, S. S., Song, E. S., Du, P., Suhaeri, M., Lee, J.-H., & Park, K. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00657 · Cited by 38 · see citing works

Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy

Allam, A. H., Yakou, M. H., Pang, L., Ernst, M., & Huynh, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767939 · Cited by 36 · see citing works

3D-Bioprinted Biomimetic Multilayer Implants Comprising Microfragmented Adipose Extracellular Matrix and Cells Improve Wound Healing in a Murine Model of Full-Thickness Skin Defects

Zhang, D., Lai, L., Fu, H., Fu, Q., & Chen, M. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c21629 · Cited by 35 · see citing works

PGE2 in fibrosis and cancer: Insights into fibroblast activation

Elwakeel, E., Brüne, B., & Weigert, A. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106339 · Cited by 35 · see citing works

S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway

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p53 and Myofibroblast Apoptosis in Organ Fibrosis

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The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

Schuster, R., Younesi, F., Ezzo, M., & Hinz, B. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041231 · Cited by 232 · see citing works

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Targeting the myofibroblast to improve wound healing

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The myofibroblast in connective tissue repair and regeneration

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Mechanisms of pathological scarring: Role of myofibroblasts and current developments

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