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Cited by 261Oral microbiology and periodontitis researchDental Health and Care UtilizationBacterial biofilms and quorum sensing

Advances in the microbial etiology and pathogenesis of early childhood caries

Open access
Hajishengallis, E., Parsaei, Y., Klein, M.I., Koo, H.·2017·Molecular Oral Microbiology
DOI 10.1111/omi.12152PMC PMC4929038
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Abstract

Early childhood caries (ECC) is one of the most prevalent infectious diseases affecting children worldwide. ECC is an aggressive form of dental caries, which, left untreated, can result in rapid and extensive cavitation in teeth (rampant caries) that is painful and costly to treat. Furthermore, it affects mostly children from impoverished backgrounds, and so constitutes a major challenge in public health. The disease is a prime example of the consequences arising from complex, dynamic interactions between microorganisms, host, and diet, leading to the establishment of highly pathogenic (cariogenic) biofilms. To date, there are no effective methods to identify those at risk of developing ECC or to control the disease in affected children. Recent advances in deep-sequencing technologies, novel imaging methods, and (meta)proteomics-metabolomics approaches provide an unparalleled potential to reveal new insights to illuminate our current understanding about the etiology and pathogenesis of the disease. In this concise review, we provide a broader perspective about the etiology and pathogenesis of ECC based on previous and current knowledge on biofilm matrix, microbial diversity, and host-microbe interactions, which could have direct implications for developing new approaches for improved risk assessment and prevention of this devastating and costly childhood health condition.

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Crossref · 10.1111/omi.12152

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  • At the structural level, access barriers, poverty, rurality, and historic inequities influence both risk and the ability to complete timely treatment.

    “At the structural level, access barriers, poverty, rurality, and historic inequities influence both risk and the ability to complete timely treatment.”

    From Equity or Two-Tier Care? Guardrails for Silver Diamine Fluoride and Delegated Early Childhood Caries Pathways (2026) · cites this paper as [2]

    The Introduction says early childhood caries disproportionately affects children from poor socioeconomic families and identifies socioeconomic factors as part of its etiology. It does not address rurality, historic inequities, access barriers, or whether these factors affect the ability to complete timely treatment. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Early childhood caries is a multifactorial disease shaped by biological, behavioral, and structural determinants.

    “Early childhood caries (ECC) is widely understood as a multifactorial disease that arises from interactions among biological, behavioral, and structural determinants.”

    From Equity or Two-Tier Care? Guardrails for Silver Diamine Fluoride and Delegated Early Childhood Caries Pathways (2026) · cites this paper as [2]

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Research works printed but not linked: 1

  1. [31]Klein MI Falsetta ML Xiao J Bowen WH Koo H 2013 The role of extracellular polysaccharides matrix in virulent oral biofilms Oral Microbial Ecology: Current Research and New Perspectives Jakubovics NS Palmer RJ Jr Norfolk, UK Caister Academic Press 63 83

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Authors
Hajishengallis, E., Parsaei, Y., Klein, M. I., & Koo, H.
Affiliations
  • University of Pennsylvania (US)
  • Universidade Estadual Paulista (Unesp) (BR)
Corresponding author
  • Hajishengallis, E.
  • Koo, H.
ORCID
Klein, M.I.
Venue
Molecular Oral Microbiology
Publisher
Wiley
Published
2016-02-04
Volume
32
Issue
1
Pages
24-34
ISSN
  • 2041-1006 (ISSN-L)
  • 2041-1014
DOI
10.1111/omi.12152
PMC
PMC4929038
OpenAlex
W2219527059
Cited by
261
References
72
Citations by year
2026: 17 · 2025: 24 · 2024: 25 · 2023: 32 · 2022: 39 · 2021: 28 · 2020: 23 · 2019: 30 · 2018: 23 · 2017: 15 · 2016: 3 · 2014: 1
FWCI
2.34
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Molecular Oral Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Funders
  • National Institutes of Health
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2014/05423‐0)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
early childhood caries, microbial etiology, pathogenesis, cariogenic biofilm, biofilm matrix, microbial diversity, host-microbe interactions, host diet, risk assessment, dental caries prevention, proteomics, metabolomics, deep sequencing
MeSH terms
Child, Preschool, Dental Caries, Feeding Behavior, Humans, Infant, Public Health, Risk Assessment, Biodiversity, Microbiota

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