Kyphoplasty increases vertebral height, decreases both pain score and opiate requirements while improving functional status
Open accessAbstract
Vertebral compression fractures can result from advanced osteoporosis, or less commonly from metastatic or traumatic insults to the vertebral column, and result in disabling pain and decreased functional capacity. Various vertebral augmentation options including kyphoplasty aim at preventing the sequelae of pain and immobility that can develop as the result of the vertebral fractures. The mechanism for pain relief following kyphoplasty is not entirely understood, and the restoration of a portion of the lost vertebral height is a subject of debate. We retrospectively reviewed radiographic imaging, pain relief, analgesic intake and functional outcomes in 67 consecutive patients who underwent single‐ or multilevel kyphoplasty with the primary goal of quantifying the restoration of lost vertebral height. We observed a mean of 45% of the lost vertebral height restored postprocedurally. Secondarily, kyphoplasty was associated with significant decreases in pain scores, daily morphine consumption and improvement in patient‐reported functional measures.
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A second smaller study in a tertiary academic center confirmed decrease in pain scores, daily morphine consumption, and improvement in functional status after kyphoplasty.
“In this vein, a second smaller study in a tertiary academic center confirmed decrease in pain scores, daily morphine consumption and improvement in functional status after kyphoplasty (236).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [236]
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- Authors
- Tolba, R., Bolash, R. B., Shroll, J., Costandi, S., Dalton, J. E., Sanghvi, C., & Mekhail, N.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Mekhail, Nagy
- Venue
- Pain Practice
- Publisher
- Wiley
- Published
- 2013-10-25
- Volume
- 14
- Issue
- 3
- Pages
- E91-7
- ISSN
- 1530-7085 (ISSN-L)
- 1533-2500
- PMC
- PMC3949154
- OpenAlex
- W2085080449
- Semantic Scholar
- 6d24f353902996db36e3463ba4fface3794a1e22
- Cited by
- 21
- References
- 34
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain Practice (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cleveland Clinic
- National Institutes of Health (5kl2rr024990-05, KL2TR000440)
- Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University
- National Center for Research Resources (KL2-RR-024990)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Spinal Fractures and Fixation Techniques
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spine and Intervertebral Disc Pathology
- Health Sciences › Medicine › Surgery › Scoliosis diagnosis and treatment
- Keywords
- kyphoplasty, vertebral compression fractures, vertebral augmentation, vertebral height restoration, analgesia, morphine consumption, functional status, osteoporosis, patient-reported outcomes
- MeSH terms
- Aged, Aged, 80 and over, Analgesics, Opioid, Female, Humans, Male, Middle Aged, Pain, Pain Measurement, Radiography, Retrospective Studies, Spine, Spinal Fractures, Treatment Outcome, Fractures, Compression, Kyphoplasty
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