A dual pathway inhibition strategy using BKM120 combined with vemurafenib is poorly tolerated in BRAF V600E/K mutant advanced melanoma
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Despite attempts to verify the efficacy of combined PI3K and MEK inhibition, no desirable clinical result has been achieved for mutant-RAS tumors, and none of the approved PI3K inhibitors is adapted to treat them.
“Despite attempts to verify the efficacy of combined inhibition of PI3K and MEK, no desirable clinical result has been achieved for mutant-RAS tumors, and none of the approved PI3K inhibitors is adapted to treat them.620–622”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [622]
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- Authors
- Algazi, A. P., Rotow, J., Posch, C., Ortiz‐Urda, S., Pelayo, A., Munster, P. N., & Daud, A.
- Affiliations
- University of California, San Francisco (US)
- Sigmund Freud Privatuniversität Wien (AT)
- UCSF Hematology and Oncology San Francisco California
- Corresponding author
- Algazi, Alain Patrick
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2019-04-13
- Volume
- 32
- Issue
- 4
- Pages
- 603-606
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W2915308757
- Cited by
- 23
- References
- 12
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pigment Cell & Melanoma Research (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Novartis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Keywords
- BKM120, vemurafenib, BRAF V600E mutation, BRAF V600K, advanced melanoma, dual pathway inhibition, combination therapy, treatment toxicity, MAPK inhibitors, BRAF inhibitors
- MeSH terms
- Vemurafenib, Aminopyridines, Humans, Melanoma, Morpholines, Mutation, Disease Progression, Proto-Oncogene Proteins B-raf
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