Cited by 23Melanoma and MAPK PathwaysColorectal Cancer Treatments and StudiesLung Cancer Treatments and Mutations

A dual pathway inhibition strategy using BKM120 combined with vemurafenib is poorly tolerated in BRAF V600E/K mutant advanced melanoma

Algazi, Alain Patrick, Rotow, Julia, Posch, Christian, Ortiz‐Urda, Susana, Pelayo, Alyson, Munster, Pamela N., Daud, Adil·2019·Pigment Cell & Melanoma Research

Abstract

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Integrity signals

Registry

Crossref · 10.1111/pcmr.12777

Cites

12 of 12 references verified0 citation errors · 0 not checkable

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  • Despite attempts to verify the efficacy of combined PI3K and MEK inhibition, no desirable clinical result has been achieved for mutant-RAS tumors, and none of the approved PI3K inhibitors is adapted to treat them.

    “Despite attempts to verify the efficacy of combined inhibition of PI3K and MEK, no desirable clinical result has been achieved for mutant-RAS tumors, and none of the approved PI3K inhibitors is adapted to treat them.620–622”

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Authors
Algazi, A. P., Rotow, J., Posch, C., Ortiz‐Urda, S., Pelayo, A., Munster, P. N., & Daud, A.
Affiliations
  • University of California, San Francisco (US)
  • Sigmund Freud Privatuniversität Wien (AT)
  • UCSF Hematology and Oncology San Francisco California
Corresponding author
Algazi, Alain Patrick
Venue
Pigment Cell & Melanoma Research
Publisher
Wiley
Published
2019-04-13
Volume
32
Issue
4
Pages
603-606
ISSN
  • 1755-1471 (ISSN-L)
  • 1755-148X
OpenAlex
W2915308757
Cited by
23
References
12
Citations by year
2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Locations
  • Pigment Cell & Melanoma Research (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
Funders
Novartis
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords
BKM120, vemurafenib, BRAF V600E mutation, BRAF V600K, advanced melanoma, dual pathway inhibition, combination therapy, treatment toxicity, MAPK inhibitors, BRAF inhibitors
MeSH terms
Vemurafenib, Aminopyridines, Humans, Melanoma, Morpholines, Mutation, Disease Progression, Proto-Oncogene Proteins B-raf

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