Clinical features of hyperadrenergic postural tachycardia syndrome in children
Abstract
Background Hyperadrenergic postural tachycardia syndrome (POTS) is the main phenotype of POTS. The aim of this study was to present our single-center experience of hyperadrenergic POTS in children and adolescents. Methods Thirty-seven patients who met the diagnostic criteria for POTS were enrolled in our study. Their orthostatic serum norepinephrine levels were determined by high-performance liquid chromatography. In a retrospective analysis, based on clinical and serum norepinephrine criteria, we analyzed the clinical features of POTS cases between the POTS-alone group and the hyperadrenergic POTS group. Results Nineteen patients (51.35%) met the diagnostic criteria for hyperadrenergic POTS and 18 patients were assigned to the POTS-alone group. Compared with the POTS-alone patients, dizziness, headache and tremulousness were more frequent in patients with hyperadrenergic POTS (P Conclusion Patients with hyperadrenergic POTS should be identified and differentiated from those with neuropathic POTS. Hyperadrenergic POTS in children and adolescents should be considered when POTS patients suffer from frequent dizziness, headache, and tremulousness. In head-up tilt testing, children and adolescents with hemodynamic characteristics of hyperadrenergic POTS had greater increments of systolic blood pressure and heart rate.
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An upright plasma NE ≥600 pg/mL is the criterion most often used to define hyperadrenergic POTS, and this threshold has been adapted in recent expert consensus statements.
“An upright plasma NE ≥600 pg/mL is the criterion most often used to define hyperadrenergic POTS,4–6 and this threshold has been adapted in recent expert consensus statements.7,8”
From Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine (2024) · cites this paper as [5]
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Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245 · see citing works
Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine
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“5,12,27 Patients with POTS have been characterized according to calf blood flow response to standing, 28 with low-flow patients probably representing those with a hyperadrenergic phenotype.”
- Authors
- Zhang, Q., Chen, X., Li, J., & Du, J.
- Affiliations
- Peking University First Hospital (CN)
- Department of Pediatrics Langfang Municipal People's Hospital Langfang Hebei China
- Corresponding author
- Du, Junbao
- Venue
- Pediatrics International
- Publisher
- Wiley
- Published
- 2014-10-15
- Volume
- 56
- Issue
- 6
- Pages
- 813-816
- ISSN
- 1328-8067 (ISSN-L)
- 1442-200X
- OpenAlex
- W1602406326
- Cited by
- 20
- References
- 13
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 1 · 2016: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatrics International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Beijing Municipal Science & Technology Commission, China (D121107001012051)
- National Twelfth 5-Year Plan for Science and Technology Support (2012BAI03B03)
- Major Basic Research Project of China (2012CB517806)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- postural orthostatic tachycardia syndrome, children, adolescents, dizziness, headache, head-up tilt, systolic blood pressure, heart rate, differential diagnosis
- MeSH terms
- Adolescent, Adrenocortical Hyperfunction, Child, Female, Humans, Male, Norepinephrine, Retrospective Studies, Postural Orthostatic Tachycardia Syndrome
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