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Cited by 76Birth, Development, and HealthGestational Diabetes Research and ManagementObesity, Physical Activity, Diet

Mother's pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood: Mother's BMI and childhood metabolic risk

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Tan, Hong Chang, Roberts, James, Catov, Janet, Krishnamurthy, Ramkumar, Shypailo, Roman, Bacha, Fida·2015·Pediatric Diabetes
DOI 10.1111/pedi.12273PMC PMC4534350
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Abstract

OBJECTIVE: Maternal adiposity is associated with poor offspring cardiometabolic health. We aimed to evaluate the relationship of maternal pre-pregnancy body mass index (BMI) on the BMI, body composition and cardiometabolic characteristics of the offspring. METHODS: Forty offspring of overweight/obese mothers (O-OW) and 28 offspring of normal weight mothers (O-NW) underwent evaluation of body composition, abdominal fat distribution, blood pressure measurement, fasting lipids and an oral glucose tolerance test. The anthropometric and cardiometabolic characteristics of O-OW were compared with those of O-NW, and the relationship to maternal BMI was evaluated. RESULTS: Subjects (mean age: 12.6 ± 0.4, female: 52.9%) had similar gestational age, birth weight, age, gender, and Tanner stage. However, O-OW had a significantly higher BMI (24.4 ± 1.2 vs. 19.7 ± 0.8 kg/m(2) , p = 0.001), % body fat (31.7 ± 1.6 vs. 24.6 ± 1.1%, p < 0.001), visceral fat (41.9 ± 4.7 vs. 26.1 ± 3.9 cm(2) , p = 0.012) with no difference in lean body mass compared with O-NW. O-OW had lower whole body insulin sensitivity index (WBISI) with an adverse cardiovascular disease risk profile [higher blood pressure (BP), triglycerides to high-density lipoprotein (HDL) ratio, hs-C-reactive protein (CRP) and lower HDL]. In addition to offspring's %body fat (β = -0.60, p < 0.001), maternal pre-pregnancy BMI (β = -0.19, p = 0.046) contributed significantly and independently to the offspring's WBISI (R(2) =0.55, p < 0.001). CONCLUSIONS: High pre-pregnancy BMI is an important contributor to excess adiposity, insulin resistance, and cardiometabolic disease risk in the offspring during childhood.

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  • Individuals exposed to maternal obesity or GDM in utero are, as adults, more likely to develop type-2 diabetes.

    “Individuals who are exposed to maternal obesity or GDM in utero are, as adults, more likely to be obese, 93 develop type‐2 diabetes 94 , 95 and die as a result of cardiovascular disease. 96”

    From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [95]

    The Discussion reports that maternal BMI predicted later type-2 diabetes in offspring in a cohort followed for over 20 years. It does not report an adult type-2 diabetes finding for offspring exposed to gestational diabetes, and this paper’s own results concern cardiometabolic risk in childhood. (LLM, conf=0.86)

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  • Maternal obesity is responsible for programming long-term health and wellbeing in the growing fetus.

    “A growing body of evidence suggests that maternal obesity is responsible for programming long‐term health and wellbeing in the growing fetus.”

    From Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: A narrative review (2022) · cites this paper as [95]

    The Introduction proposes that maternal obesity may influence offspring obesity risk through intra-uterine programming, and the Discussion describes emerging evidence for that possibility. The paper supports a link to later childhood adiposity and cardiometabolic risk, but does not establish that maternal obesity is responsible for programming long-term health and wellbeing broadly; it says the mechanisms remain unresolved. (LLM, conf=0.82)

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Authors
Tan, H. C., Roberts, J., Catov, J., Krishnamurthy, R., Shypailo, R., & Bacha, F.
Affiliations
  • Baylor College of Medicine (US)
  • University of Pittsburgh (US)
  • Texas Children's Hospital (US)
Corresponding author
Bacha, Fida
ORCID
Venue
Pediatric Diabetes
Publisher
Wiley
Published
2015-03-20
Volume
16
Issue
6
Pages
419-426
ISSN
1399-543X (ISSN-L)
DOI
10.1111/pedi.12273
PMC
PMC4534350
OpenAlex
W1945085254
Cited by
76
References
3
Citations by year
2026: 4 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 11 · 2021: 6 · 2020: 11 · 2019: 14 · 2018: 9 · 2017: 4 · 2016: 3 · 2015: 2
FWCI
5.98
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 165 d)
Locations
  • Pediatric Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R03HD059798, UL1 RR024153)
  • Children’s Hospital of Pittsburgh Foundation
  • USDA/ARS (6250-5100-054)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
maternal pre-pregnancy BMI, maternal obesity, childhood obesity, body composition, visceral fat, insulin resistance, blood pressure, dyslipidemia, C-reactive protein, abdominal fat distribution
MeSH terms
Adolescent, Cardiovascular Diseases, Child, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Male, Obesity, Pennsylvania, Pregnancy, Risk Factors, Texas, Cohort Studies, Biomarkers, Body Mass Index, Metabolic Syndrome, Maternal Nutritional Physiological Phenomena, Fetal Development, Adiposity, Overweight, Pediatric Obesity

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