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Cited by 354Bariatric Surgery and OutcomesBirth, Development, and HealthObesity, Physical Activity, Diet

Effects of Maternal Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity

Smith, J., Cianflone, K., Biron, S., Hould, F. S., Lebel, S., Marceau, S., Lescelleur, O., Biertho, L. +3 more·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2009-0709
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Abstract

BACKGROUND AND OBJECTIVES: By studying cardiometabolic risk factors in children born after maternal biliopancreatic diversion bariatric surgery (AMS) compared with those in children born before maternal surgery (BMS), we tested the hypothesis that significant maternal weight loss may modify obesity-related factors transmitted via the intrauterine environment. DESIGN: Anthropometry and fasting blood levels were studied in 49 mothers who had lost 36 +/- 1.8% body weight sustained for 12 +/- 0.8 yr and their 111 children (54 BMS and 57 AMS) aged 2.5-26 yr. RESULTS: AMS children had lower birth weight (2.9 +/- 0.1 AMS vs. 3.3 +/- 0.1 kg BMS, P = 0.003) associated with a reduced prevalence of macrosomia (1.8 AMS vs. 14.8% BMS, P = 0.03) with no difference in underweight. At the time of follow-up, AMS children exhibited 3-fold lower prevalence of severe obesity (11 vs. 35%, P = 0.004), greater insulin sensitivity (homeostasis model assessment of insulin resistance index 3.4 +/- 0.3 vs. 4.8 +/- 0.5, P = 0.02), improved lipid profile (cholesterol/high-density lipoprotein cholesterol 2.96 +/- 0.11 vs 3.40 +/- 0.18, P = 0.03; high-density lipoprotein cholesterol 1.50 +/- 0.05 vs. 1.35 +/- 0.05 mmol/liter, P = 0.04), lower C-reactive protein (0.88 +/- 0.17 vs. 2.00 +/- 0.34 microg/ml, P = 0.004), and leptin (11.5 +/- 1.5 vs.19.7 +/- 2.5 ng/ml, P = 0.005) and increased ghrelin (1.28 +/- 0.06 vs.1.03 +/- 0.06 ng/ml, P = 0.005) than BMS offspring (AMS vs. BMS, respectively, for all). CONCLUSIONS: This unique study of children aged 2.5-26 yr born before and after maternal antiobesity surgery demonstrated improvements in cardiometabolic markers sustained into adolescence, attributable to an improved intrauterine environment.

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  • Studies of women who have undergone bariatric surgery show that siblings born of women post surgery displayed a reduced prevalence of obesity compared to those born before surgery, providing compelling evidence for a role for developmental programming rather than genetic factors in the maternal transmission of obesity.

    “Compelling evidence showing a role for developmental programming rather than genetic factors in the maternal transmission of obesity comes from studies of women who have undergone bariatric surgery to reduce weight; siblings born of women post surgery displayed a reduced prevalence of obesity compared to those born before surgery [86, 87].”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [86]

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Authors
Smith, J., Cianflone, K., Biron, S., Hould, F. S., Lebel, S., Marceau, S., Lescelleur, O., Biertho, L., Simard, S., Kral, J. G., & Marceau, P.
Affiliations
  • Institut universitaire de cardiologie et de pneumologie de Québec (CA)
  • Université Laval (CA)
  • SUNY Downstate Health Sciences University (US)
Corresponding author
Marceau, P.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-11-01
Volume
94
Issue
11
Pages
4275-4283
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2009-0709
OpenAlex
W1996374391
Cited by
354
References
36
Citations by year
2026: 6 · 2025: 7 · 2024: 13 · 2023: 19 · 2022: 16 · 2021: 22 · 2020: 23 · 2019: 24 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 29 · 2014: 34 · 2013: 32 · 2012: 31
FWCI
23.32
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (MOP64446)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
biliopancreatic diversion, maternal weight loss, intergenerational transmission of obesity, offspring obesity, intrauterine environment, birth weight, macrosomia, insulin sensitivity, cardiometabolic risk factors, leptin, ghrelin, C-reactive protein, lipid profile, childhood obesity prevention
MeSH terms
Birth Weight, Cross-Sectional Studies, Female, Fetal Macrosomia, Follow-Up Studies, Humans, Infant, Low Birth Weight, Infant, Newborn, Obesity, Pregnancy, Uterus, Weight Loss, Body Size, Bariatric Surgery

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