Randomized trial of three phototherapy methods for the treatment of acne vulgaris in C hinese patients
Abstract
Summary: Background and Aims: Acne vulgaris is common in A sian populations. We compared three methods of phototherapy for the treatment of moderate to severe facial acne vulgaris in C hinese patients. Methods: Patients were randomly assigned to receive photodynamic therapy (PDT), intense pulsed light (IPL) or blue–red light‐emitting diode (LED) phototherapy to the right side of the face until the inflammatory lesion count reduced by ≥ 90%. Patients were examined at 1 and 3 months after the final treatment. Results: We enrolled 150 patients (92 males; mean age, 28 years). At 1 month, ≥90% clearance or moderate improvement occurred in 46/50 (92%), 29/50 (58%) and 22/50 (44%) patients in the PDT, IPL and LED groups, respectively (mean number of sessions required, PDT: 3 ± 1.52; IPL: 6 ± 2.15; LED: 9 ± 3.34). Forty‐six (92%) patients experienced mild to moderate pain, erythema and edema after PDT, which resolved within 5–7 days. Slight erythema and stinging were reported immediately after IPL and LED, resolving within 2 h. After 3 months, minimal papules and pustules were observed in 4 patients in the PDT group, 7 in the IPL group and 12 in the LED group, but no nodular pustules recurred. Conclusions: Phototherapy is efficacious for moderate to severe facial acne vulgaris.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For the treatment of acne, the total dose of red light needs to be adjusted for FST.
“For the treatment of acne, the total dose of red light needs to be adjusted for FST as discussed by multiple authors for patients of Asian origin.65,118–120”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [119]
Cites
Topical ALA-Photodynamic Therapy for the Treatment of Acne Vulgaris
Hongcharu, W., Taylor, C. R., Aghassi, D., Suthamjariya, K., Anderson, R. R., & Chang, Y. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00046.x · Cited by 527 · see citing works
Effect of NASA Light-Emitting Diode Irradiation on Wound Healing
Whelan, H. T., Smits, R. L., Buchmann, E. V., Whelan, N. T., Turner, S. G., Margolis, D. A., Cevenini, V., Stinson, H., Ignatius, R. W., Martin, T. S., et al. (2001) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/104454701753342758 · Cited by 490 · see citing works
Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris
Papageorgiou, P., Katsambas, A., & Chu, A. C. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03481.x · Cited by 435 · see citing works
Ashkenazi, H., Malik, Z., Harth, Y., & Nitzan, Y. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2003.tb00644.x · Cited by 374 · see citing works
Macrophage responsiveness to light therapy
Young, S., Bolton, P. A., Dyson, M., Harvey, W. K., & Diamantopoulos, C. (1989) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1900090513 · Cited by 330 · see citing works
Divaris, D. X. G., Kennedy, J. C., & Pottier, R. (1990) · PubMed · Cited by 321 · see citing works
A review of the use of combination therapies for the treatment of acne vulgaris
Leyden, J. J. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/s0190-9622(03)01154-x · Cited by 258 · see citing works
THE PREVALENCE OF ACNE VULGARIS IN ADOLESCENCE
Burton, J. L., Cunliffe, W. J., STAFFORD, I., & Shuster, S. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb07195.x · Cited by 241 · see citing works
Pollock, B. G., Turner, D., Stringer, M. R., Bojar, R. A., Goulden, V., Stables, G. I., & Cunliffe, W. J. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06110.x · Cited by 238 · see citing works
Whelan, H. T., Buchmann, E. V., Dhokalia, A., et al. (2003) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/104454703765035484 · Cited by 219 · see citing works
Coates, P., Vyakrnam, S., Eady, E. A., JONES, C. E., Cove, J. H., & Cunliffe, W. J. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04690.x · Cited by 210 · see citing works
Itoh, Y., Ninomiya, Y., Tajima, S., & Ishibashi, A. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04086.x · Cited by 203 · see citing works
Kawada, A., Aragane, Y., Kameyama, H., Sangen, Y., & Tezuka, T. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(02)00068-3 · Cited by 199 · see citing works
Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV
Lee, S. Y., You, C. E., & Park, M. Y. (2006) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20412 · Cited by 171 · see citing works
Whelan, H. T., Connelly, J. F., Hodgson, B. D., et al. (2002) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/104454702320901107 · Cited by 167 · see citing works
Systematic review of Propionibacterium acnes resistance to systemic antibiotics
Cooper, A. (1998) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1998.tb140250.x · Cited by 149 · see citing works
Photodynamic Therapy for Acne Vulgaris With Topical 5-Aminolevulinic Acid
Itoh, Y., Ninomiya, Y., Tajima, S., & Ishibashi, A. (2000) · Archives of Dermatology · doi:10.1001/archderm.136.9.1093 · Cited by 139 · see citing works
The effective treatment of acne vulgaris by a high‐intensity, narrow band 405–420 nm light source
Elman, M., Slatkine, M., & Harth, Y. (2003) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170310001276 · Cited by 136 · see citing works
Phototherapy of Acne Vulgaris with Visible Light
Sigurdsson, V., Knulst, A. C., & van Weelden, H. (2009) · Dermatology · doi:10.1159/000246114 · Cited by 132 · see citing works
Topical Treatment in Acne: Current Status and Future Aspects
Gollnick, H. P. M., & Krautheim, A. (2003) · Dermatology · doi:10.1159/000067820 · Cited by 129 · see citing works
Blue light phototherapy in the treatment of acne
Tzung, T., Wu, K., & Huang, M. (2004) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2004.00109.x · Cited by 129 · see citing works
Eady, E. A. (1998) · Dermatology · doi:10.1159/000017869 · Cited by 128 · see citing works
Light Therapy in the Treatment of Acne Vulgaris
Elman, M., & Lebzelter, J. (2004) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2004.30053.x · Cited by 126 · see citing works
Physiopathology of acne vulgaris: recent data, new understanding of the treatments.
Pawin, H., Beylot, C., Chivot, M., Faure, M., Poli, F., Revuz, J. E., & Dréno, B. (2004) · PubMed · Cited by 112 · see citing works
Mark, K. A., Sparacio, R. M., Voigt, A., et al. (2003) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2003.29141.x · Cited by 96 · see citing works
Phototherapy in the Treatment of Acne Vulgaris
Charakida, A., Seaton, E. D., Charakida, M., Mouser, P., Avgerinos, A., & Chu, A. C. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405040-00001 · Cited by 93 · see citing works
Psychosocial Impact of Acne vulgaris
Mulder, M., Sigurdsson, V., van Zuuren, E. J., Klaassen, E., Faber, J. A. J., de Wit, J. B. F., & van Vloten, W. A. (2001) · Dermatology · doi:10.1159/000051726 · Cited by 88 · see citing works
ROSS, E. V. (2005) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.05024.x · Cited by 77 · see citing works
Gold, M. H., Rao, J., Goldman, M. P., et al. (2005) · PubMed · Cited by 76 · see citing works
The role of pulsed light and heat energy (LHETM) in acne clearance
Elman, M., & LASK, G. P. (2004) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170410035584 · Cited by 67 · see citing works
Intense pulsed-light photorejuvenation
Sadick, N. S., & Weiss, R. A. (2002) · Seminars in Cutaneous Medicine and Surgery · doi:10.1053/sder.2002.36902 · Cited by 57 · see citing works
Treatment of rosacea with intense pulsed light.
Taub, A. F. (2003) · PubMed · Cited by 57 · see citing works
Lasers and Light Therapy for Acne Vulgaris
Bhardwaj, S. S., Rohrer, T. E., & Arndt, K. A. (2005) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2005.04.001 · Cited by 54 · see citing works
Less Common Methods to Treat Acne
KAMINSKY, A. R. D. (2003) · Dermatology · doi:10.1159/000067824 · Cited by 53 · see citing works
Quality of life among schoolchildren with acne: Results of a cross-sectional study
Janković, S., Djordjević, S., Marinković, J., et al. (2012) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.98076 · Cited by 52 · see citing works
Effect of Smooth Pulsed Light at 400 to 700 and 870 to 1,200 nm for Acne Vulgaris in Asian Skin
Kawana, S., Tachihara, R., Kato, T., & Omi, T. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01380.x · Cited by 44 · see citing works
Optic nerve sheath fenestration with a novel wavelength produced by the free electron laser (FEL)
Joos, K. M., Shen, J., SHETLAR, D. J., & Casagrande, V. A. (2000) · Lasers in Surgery and Medicine · doi:10.1002/1096-9101(2000)27:3 · Cited by 39 · see citing works
Knor, T. (2005) · PubMed · Cited by 32 · see citing works
The new age of acne therapy: Light, lasers, and radiofrequency
Rotunda, A. M., Bhupathy, A. R., & Rohrer, T. E. (2004) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764170410008124 · Cited by 30 · see citing works
Mark, K. A., Sparacio, R. M., Voigt, A., et al. (2003) · Dermatologic Surgery · doi:10.1097/00042728-200306000-00009 · Cited by 26 · see citing works
Acne vulgaris: one treatment does not fit all.
Longshore, S. J., & Hollandsworth, K. (2003) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.70.8.670 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2024) · Journal of Biomedical Optics · doi:10.1117/1.jbo.29.1.010901 · Cited by 72 · see citing works
- Authors
- Liu, L., Fan, X., An, Y., Zhang, J., Wang, C., & Yang, R.
- Affiliations
- The Military General Hospital of Beijing PLA (CN)
- Department of Dermatology General Hospital of Beijing Military Region of PLA Beijing China
- Corresponding author
- Yang, Rong‐Ya
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2014-01-06
- Volume
- 30
- Issue
- 5
- Pages
- 246-253
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W1600477218
- Cited by
- 46
- References
- 41
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 1
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- acne, phototherapy, photodynamic therapy, intense pulsed light, facial acne, treatment efficacy, adverse effects, Chinese patients
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Female, Humans, Male, Phototherapy, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
