Psoriasis and daily low‐emission phototherapy: effects on disease and vitamin D level
Open accessAbstract
Background/Purpose: Hospital‐based phototherapy is a widely accepted treatment modality in psoriasis patients. It, however, requires several hospital visits weekly, interfering with (school)work. Home ultraviolet (UV) treatment has been proven effective before but is only available in certain countries, and safety aspects play a part in reluctancy to prescribe this treatment. Patients, however, are usually keen on the use of phototherapy as it is effective and gives them the possibility of reducing the amount of topical treatment needed. In this study, we assess the effectivity of a low‐emission UV device used daily. Methods: Sixty‐two patients were treated for 6 months either with daily low‐emission UV treatment and mometasone ointment 0.1% or with mometasone ointment 0.1% alone. Psoriasis severity scores, quality of life, vitamin D level, and blood pressure were monitored every 2 months during the study. Results: Patients treated with daily low‐emission UV treatment showed a significant improvement in psoriasis severity, quality of life, amount of steroid ointment used, and vitamin D levels. Conclusion: Daily low‐emission UV therapy is an effective treatment for psoriasis patients, diminishing the amount of steroid ointment needed and improving disease activity, quality of life, and vitamin D scores. Further investigation, however, is necessary.
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Repeated low-dose UVR promotes photoadaptation, increases the skin inflammation threshold, and reduces susceptibility to sunburns.
“Yet, several studies suggest that repeated lowdose UVR promotes photoadaptation, increase the skin inflammation threshold, and reduce susceptibility to sunburns (de Winter et al, 2001;Franken et al, 2015;Laihia et al, 2005).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Franken et al, 2015
Materials and Methods (page unavailable) describes daily low-dose UVB exposure, and the Discussion (page unavailable) reports that treated patients did not report redness or sunburn. Neither passage assesses photoadaptation, a change in the skin’s inflammation threshold, or reduced susceptibility to sunburn; absence of sunburn during treatment does not establish those effects. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThis pattern is consistent with suppression of both Th1 and Th2 responses after phototherapy in atopic dermatitis, likely due to induction of T-cell apoptosis.
“This pattern is consistent with the suppression of both T helper 1 and T helper 2 responses after phototherapy in atopic dermatitis, likely due to the induction of T-cell apoptosis (Franken et al, 2015;Musters et al, 2021;Ozawa et al, 1999).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Franken et al, 2015
The Abstract and Patients sections describe phototherapy in psoriasis, not atopic dermatitis. Searches for Th1/Th2 suppression and T-cell apoptosis found no passage in our copy addressing the claimed immune response or mechanism. (LLM, conf=0.76)
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Cites
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de Boer, F., Kezic, S., van der Lelie, G., Motazedi, E., Rustemeyer, T., van Dijk, A., Almasian, M., Jakasa, I., & van der Molen, H. F. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.01.024 · Cited by 4 · see citing works
Self-citation
- Authors
- Franken, S. M., Witte, B., Pavel, S., & Rustemeyer, T.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Department of Epidemiology and Biostatistics VU University Medical Center Amsterdam The Netherlands
- Department of Dermatology Mauritskliniek Treatment Centre Utrecht The Netherlands
- Corresponding author
- Franken, Sylvie Mireille
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2014-12-03
- Volume
- 31
- Issue
- 2
- Pages
- 83-89
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W1584286285
- Cited by
- 14
- References
- 11
- Citations by year
- 2025: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Keywords
- psoriasis, home phototherapy, topical corticosteroids, vitamin D levels, psoriasis severity, quality of life, blood pressure, steroid-sparing therapy
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Psoriasis, Quality of Life, Ultraviolet Therapy, Vitamin D
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