The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Immunology of human schistosomiasis
Open accessAbstract
Summary: There is a wealth of immunologic studies that have been carried out in experimental and human schistosomiasis that can be classified into three main areas: immunopathogenesis, resistance to reinfection and diagnostics. It is clear that the bulk of, if not all, morbidity due to human schistosomiasis results from immune‐response‐based inflammation against eggs lodged in the body, either as regulated chronic inflammation or resulting in fibrotic lesions. However, the exact nature of these responses, the antigens to which they are mounted and the mechanisms of the critical regulatory responses are still being sorted out. It is also becoming apparent that protective immunity against schistosomula as they develop into adult worms develops slowly and is hastened by the dying of adult worms, either naturally or when they are killed by praziquantel. However, as with anti‐egg responses, the responsible immune mechanisms and inducing antigens are not clearly established, nor are any potential regulatory responses known. Finally, a wide variety of immune markers, both cellular and humoral, can be used to demonstrate exposure to schistosomes, and immunologic measurement of schistosome antigens can be used to detect, and thus diagnose, active infections. All three areas contribute to the public health response to human schistosome infections.
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Cites
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Cited by
Osakunor, D. N. M., Mduluza, T., Osei-Hyiaman, D., Burgess, K., Woolhouse, M. E. J., & Mutapi, F. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008866 · Cited by 20
The role of C/EBP homologous protein (CHOP) in regulating macrophage polarization in RAW264.7 cells
Liu, L., Peng, S., Duan, M., Liu, C., Li, L., Zhang, X., Ren, B., & Tian, H. (2021) · Microbiology and Immunology · doi:10.1111/1348-0421.12937 · Cited by 15
Metadata
- Authors
- Colley, D. G., & Secor, W. E.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 2014-08
- Volume
- 36
- Issue
- 8
- Pages
- 347-357
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W2089086808
- Cited by
- 286
- References
- 94
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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