Schistosoma haematobium infection is associated with alterations in energy and purine-related metabolism in preschool-aged children
Open accessAbstract
Helminths are parasitic worms that infect over a billion people worldwide. The pathological consequences from infection are due in part, to parasite-induced changes in host metabolic pathways. Here, we analyse the changes in host metabolic profiles, in response to the first Schistosoma haematobium infection and treatment in Zimbabwean children. A cohort of 83 schistosome-negative children (2-5 years old) as determined by parasitological examination, guardian interviews and examination of medical records, was recruited at baseline. Children were followed up after three months for parasitological diagnosis of their first S. haematobium infection, by detection of parasite eggs excreted in urine. Children positive for infection were treated with the antihelminthic drug praziquantel, and treatment efficacy checked three months after treatment. Blood samples were taken at each time point, and capillary electrophoresis mass spectrometry in conjunction with multivariate analysis were used to compare the change in serum metabolite profiles in schistosome-infected versus uninfected children. Following baseline at the three-month follow up, 11 children had become infected with S. haematobium (incidence = 13.3%). Our results showed that infection with S. haematobium was associated with significant increases (>2-fold) in discriminatory metabolites, linked primarily with energy (G6P, 3-PG, AMP, ADP) and purine (AMP, ADP) metabolism. These observed changes were commensurate with schistosome infection intensity, and levels of the affected metabolites were reduced following treatment, albeit not significantly. This study demonstrates that early infection with S. haematobium is associated with alterations in host energy and purine metabolism. Taken together, these changes are consistent with parasite-related clinical manifestations of malnutrition, poor growth and poor physical and cognitive performance observed in schistosome-infected children.
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Early childhood infections with schistosomes affect metabolism in children aged 5 years and below.
“We have recently reported that early childhood infections with schistosomes affect metabolism in children aged 5 years and below, [39]”
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Mutapi, F., Pfavayi, L., Osakunor, D., Lim, R., Kasambala, M., Mutemeri, A., Rusakaniko, S., Chibanda, D., & Mduluza, T. (2021) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0009660 · Cited by 25 · see citing works
“We have recently reported that early childhood infections with schistosomes affect metabolism in children aged 5 years and below, [39], which may have a subsequent impact on ECD.”
BackgroundSelf-citationZhu, P., Wu, K., Zhang, C., Batool, S. S., Li, A., Yu, Z., & Huang, J. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011498 · Cited by 17 · see citing works
Untargeted serum metabolomics analysis of Trichinella spiralis-infected mouse
Chienwichai, P., Thiangtrongjit, T., Tipthara, P., Tärning, J., Adisakwattana, P., & Reamtong, O. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011119 · Cited by 12 · see citing works
Chienwichai, P., Nogrado, K. S., Tipthara, P., Tärning, J., Limpanont, Y., Chusongsang, P., Chusongsang, Y., Tanasarnprasert, K., Adisakwattana, P., & Reamtong, O. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.910177 · Cited by 10 · see citing works
Zdesenko, G., Mduluza, T., & Mutapi, F. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.914372 · Cited by 10 · see citing works
Prevalence Mapping of Schistosoma mansoni Among Pre-school Age Children in Rwanda
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Osakunor, D. N. M., Ishida, K., Lamanna, O. K., Rossi, M., Dwomoh, L., & Hsieh, M. H. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010176 · Cited by 8 · see citing works
Self-citationMetabolomics for biomarker discovery in schistosomiasis: A systematic scoping review
Midzi, H., Vengesai, A., Muleya, V., Kasambala, M., Mduluza-Jokonya, T. L., Chipako, I., Siamayuwa, C. E., Mutapi, F., Naicker, T., & Mduluza, T. (2023) · Frontiers in Tropical Diseases · doi:10.3389/fitd.2023.1108317 · Cited by 6 · see citing works
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Paediatric schistosomiasis: last mile preparations for deploying paediatric praziquantel
Mutapi, F., Garba, A., Woolhouse, M. E. J., & Kazyoba, P. E. (2024) · Trends in Parasitology · doi:10.1016/j.pt.2024.06.011 · Cited by 4 · see citing works
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Gene expression changes in mammalian hosts during schistosomiasis: a review
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Midzi, H., Naicker, T., Vengesai, A., Choto, E. T., Muchesa, P., Kasambala, M., Mduluza-Jokonya, T. L., Muleya, V., Nyagumbo, E., Kapanga, D. T., et al. (2024) · Frontiers in Tropical Diseases · doi:10.3389/fitd.2024.1358514 · Cited by 1 · see citing works
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Schistosomiasis and stunting: microbial and metabolic mechanisms in early childhood
Osakunor, D. N. M., Pfavayi, L. T., Mduluza, T., & Mutapi, F. (2026) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2025.0094
Self-citationChienwichai, P., Tipthara, P., Tärning, J., Limpanont, Y., Tanasanprasert, K., Kiangkoo, N., Thiangtrongjit, T., Adisakwattana, P., & Reamtong, O. (2026) · Current Research in Parasitology and Vector-Borne Diseases · doi:10.1016/j.crpvbd.2026.100398
- Authors
- Osakunor, D. N. M., Mduluza, T., Osei-Hyiaman, D., Burgess, K., Woolhouse, M. E. J., & Mutapi, F.
- Affiliations
- University of Edinburgh (GB)
- University of Zimbabwe (ZW)
- Corresponding author
- Osakunor, Derick N. M.
- Mduluza, Takafira
- Burgess, Karl
- Woolhouse, Mark E. J.
- Mutapi, Francisca
- ORCID
- Venue
- PLoS neglected tropical diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-12-14
- Volume
- 14
- Issue
- 12
- Pages
- e0008866
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC7735607
- OpenAlex
- W3111718474
- Cited by
- 20
- References
- 96
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- Thrasher Research Fund (12440)
- Wellcome Trust (108061/Z/15/Z)
- Oak Foundation
- Darwin Trust of Edinburgh
- National Institute for Health Research (16/136/33)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- Schistosoma haematobium, schistosomiasis, energy metabolism, purine metabolism, serum metabolite profiles, praziquantel treatment, preschool children, infection intensity, malnutrition, host-parasite interactions
- MeSH terms
- Animals, Anthelmintics, Child, Preschool, Energy Metabolism, Female, Humans, Male, Praziquantel, Purines, Schistosoma haematobium, Schistosomiasis haematobia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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