Enhanced identification of maternal hepatitis C virus infection using existing public health surveillance systems.
Open accessAbstract
BACKGROUND: Hepatitis C virus (HCV) infection is under-recognized among US adults and children. Prenatal HCV screening may help close the diagnosis gap among women while also identifying at-risk infants. Current surveillance efforts for maternal HCV rely primarily on birth certificate data. We sought a more accurate assessment of HCV prevalence among pregnant women in Ohio by combining existing public health surveillance data. METHODS: Vital Statistics (VS) birth certificate data and Ohio Disease Reporting System (ODRS) HCV case data, both available through the Ohio Department of Health, were linked to determine rates of past or present HCV infection among women giving birth from 2012 to 2015 in Ohio, overall and by county. Among women with available test results, the proportion with present HCV infection indicated by detectable viraemia during pregnancy was calculated. RESULTS: Birth certificate data identified 4695 deliveries to women with past/present HCV infection during the study period. Linkage to ODRS revealed an additional 1778 deliveries to women with past/present infection, including 355 with confirmed viraemia during pregnancy. The prevalence of past/present HCV among pregnant women in Ohio rose from 0.82% in 2012 to 1.54% in 2015. CONCLUSIONS: Maternal HCV infection is under-recognized and increasing in prevalence. Current case identification processes are inadequate in pregnancy, even among women with prior positive HCV testing. Alternative approaches, including enhanced risk factor-based screening or universal prenatal screening in high prevalence settings, are needed to improve rates of HCV recognition among reproductive-aged women and newborns at risk of vertical transmission.
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The rate of hepatitis C virus (HCV) infection has increased among pregnant women in recent years.
“The rate of hepatitis C virus (HCV) infection has increased among pregnant women in recent years (150–153).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [153]
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Cites
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
1 (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.023 · Cited by 1,080 · see citing works
Ghany, M. G., Morgan, T. R. M., & Panel, A. H. C. G. (2019) · Hepatology · doi:10.1002/hep.31060 · Cited by 956 · see citing works
Zibbell, J. E., Iqbal, K., Patel, R. C., Suryaprasad, A. G., Sanders, K. J., Moore-Moravian, L., Serrecchia, J., Blankenship, S., Ward, J. W., & Holtzman, D. J. (2015) · PubMed Central · Cited by 510 · see citing works
Suryaprasad, A. G., White, J. Z., Xu, F., Eichler, B. A., Hamilton, J. J., Patel, A. S., Hamdounia, S. B., Church, D., Barton, K., Fisher, C., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu643 · Cited by 500 · see citing works
Vertical Transmission of Hepatitis C Virus: Systematic Review and Meta-analysis
Beňová, L., Mohamoud, Y. A., Calvert, C., & Abu-Raddad, L. J. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu447 · Cited by 477 · see citing works
Moyer, V. A. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-5-201309030-00672 · Cited by 475 · see citing works
Chronic hepatitis C virus (HCV) disease burden and cost in the United States
Razavi, H., ElKhoury, A. C., Elbasha, E., Estes, C., Pasini, K., Poynard, T., & Kumar, R. (2013) · Hepatology · doi:10.1002/hep.26218 · Cited by 474 · see citing works
Yehia, B. R., Schranz, A. J., Umscheid, C. A., & Re, V. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101554 · Cited by 441 · see citing works
Toward a more accurate estimate of the prevalence of hepatitis C in the United States
Edlin, B. R., Eckhardt, B. J., Shu, M. A., Holmberg, S. D., & Swan, T. (2015) · Hepatology · doi:10.1002/hep.27978 · Cited by 433 · see citing works
Rising mortality associated with hepatitis C virus in the United States, 2003–2013
Ly, K. N., Hughes, E. M., Jiles, R. B., & Holmberg, S. D. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw111 · Cited by 358 · see citing works
Marschall, H., Shemer, E. W., Ludvigsson, J. F., & Stephansson, O. (2013) · Hepatology · doi:10.1002/hep.26444 · Cited by 240 · see citing works
Evolving Epidemiology of Hepatitis C Virus in the United States
Klevens, R. M., Hu, D. J., Jiles, R., & Holmberg, S. D. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis393 · Cited by 214 · see citing works
Hepatitis C in pregnancy: screening, treatment, and management
Hughes, B. L., Page, C. M., & Kuller, J. A. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.07.039 · Cited by 166 · see citing works
Ly, K. N., Jiles, R. B., Teshale, E. H., Foster, M. A., Pesano, R. L., & Holmberg, S. D. (2017) · Annals of Internal Medicine · doi:10.7326/m16-2350 · Cited by 148 · see citing works
Persistence Rate and Progression of Vertically Acquired Hepatitis C Infection
European Paediatric Hepatitis C Virus Infection Network, Tovo, P., Pembrey, L., & Newell, M. (2000) · The Journal of Infectious Diseases · doi:10.1086/315264 · Cited by 142 · see citing works
Koneru, A., Nelson, N. P., Hariri, S., Canary, L., Sanders, K. J., Maxwell, J. F., Huang, X., Leake, J. A. D., Ward, J. W., & Vellozzi, C. J. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6528a2 · Cited by 138 · see citing works
Barocas, J. A., Brennan, M. B., Hull, S. J., Stokes, S., Fangman, J. J. W., & Westergaard, R. P. (2014) · Harm Reduction Journal · doi:10.1186/1477-7517-11-1 · Cited by 133 · see citing works
Failure to Test and Identify Perinatally Infected Children Born to Hepatitis C Virus–Infected Women
Kuncio, D. E., Newbern, E. C., Johnson, C. C., & Viner, K. M. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw026 · Cited by 118 · see citing works
Estimates on HCV disease burden worldwide – filling the gaps
Wedemeyer, H. H., Dore, G. J., & Ward, J. W. (2015) · Journal of Viral Hepatitis · doi:10.1111/jvh.12371 · Cited by 114 · see citing works
Hepatitis C virus infection among women giving birth—Tennessee and United States, 2009–2014.
Patrick, S. W., Bauer, A. M., Warren, M. D., Jones, T. F., & Wester, C. (2017) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6618a3 · Cited by 113 · see citing works
Clinical Spectrum and Histopathologic Features of Chronic Hepatitis C Infection in Children
Mohan, P., Colvin, C. A., Glymph, C., Chandra, R. R., Kleiner, D. E., Patel, K. M., Luban, N. L. C., & Alter, H. J. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.11.037 · Cited by 90 · see citing works
Chou, R., Cottrell, E. B., Wasson, N., et al. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-2-201301150-00574 · Cited by 89 · see citing works
Delgado‐Borrego, A., Smith, L., Jonas, M. M., et al. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.05.002 · Cited by 63 · see citing works
Watts, T., Stockman, L., Martin, J., Guilfoyle, S., & Vergeront, J. M. (2017) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6642a3 · Cited by 49 · see citing works
Wherry, L. (2017) · Health Services Research · doi:10.1111/1475-6773.12820 · Cited by 43 · see citing works
Physician Nonadherence With a Hepatitis C Screening Program
Southern, W. N., Drainoni, M., Smith, B. D., Koppelman, E. A., McKee, M. D., Christiansen, C. L., Gifford, A. L., Weinbaum, C. M., & Litwin, A. H. (2013) · Quality Management in Health Care · doi:10.1097/qmh.0000000000000007 · Cited by 26 · see citing works
Examining hepatitis c virus testing practices in primary care clinics
Almario, C. V., Vega, M., Trooskin, S. B., et al. (2011) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2011.01539.x · Cited by 21 · see citing works
Reduced Risk of Inadequate Prenatal Care in the Era After Medicaid Expansions in California
Hessol, N. A., Vittinghoff, E., & Fuentes‐Afflick, E. (2004) · Medical Care · doi:10.1097/01.mlr.0000124244.26926.4d · Cited by 19 · see citing works
Hepatitis C Virus Infection in Pregnancy and Childhood
Wen, J. W., Ohmer, S., & Honegger, J. R. (2016) · Springer eBooks · doi:10.1007/978-4-431-56101-9_7 · Cited by 2 · see citing works
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
- Authors
- Gowda, C., Kennedy, S., Glover, C., Prasad, M. R., Wang, L., & Honegger, J. R.
- Affiliations
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
- Corresponding author
- Honegger, Jonathan R.
- Venue
- Paediatric and Perinatal Epidemiology
- Publisher
- Wiley
- Published
- 2018-07
- Volume
- 32
- Issue
- 4
- Pages
- 401-410
- ISSN
- 0269-5022 (ISSN-L)
- 1365-3016
- PMC
- PMC6512319
- OpenAlex
- W2809797744
- Cited by
- 15
- References
- 29
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Paediatric and Perinatal Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Research Institute, Nationwide Children's Hospital (R01‐AI096882)
- Ohio State University (UL1TR001070)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- hepatitis C virus, maternal HCV infection, prenatal screening, birth certificate data, vertical transmission, Ohio
- MeSH terms
- Adult, Female, Health Surveys, Hepatitis C, Humans, Ohio, Pregnancy, Pregnancy Complications, Infectious, Prenatal Diagnosis, Risk Factors, Prevalence, Practice Guidelines as Topic, Infectious Disease Transmission, Vertical, Pregnant People, Pregnant Women, Public Health Surveillance
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