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Cited by 62Sleep and related disordersDementia and Cognitive Impairment ResearchCircadian rhythm and melatonin

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Mirtazapine does not improve sleep disorders in Alzheimer's disease: results from a double‐blind, placebo‐controlled pilot study

Scoralick, Francisca M., Louzada, Luciana L., Quintas, Juliana L., Naves, Janeth O.S., Camargos, Einstein F., Nóbrega, Otávio T.·2017·Psychogeriatrics
DOI 10.1111/psyg.12191
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Abstract

Aim: The aim of this study was to test the efficacy and safety of mirtazapine in the treatment of sleep disorders in patients with A lzheimer's disease by means of a randomized, double‐blind, placebo‐controlled trial. Measurements were obtained for 7 days before intervention (baseline) and for 2 weeks after the onset of treatment. Methods: A lzheimer's disease patients with sleep disorders (n = 24) received 15‐mg mirtazapine (n = 8) or placebo (n = 16) once daily at 2100 hours for 2 weeks. Patients were evaluated with actigraphy and structured scales before and after intervention. Historical control was employed. Results: Treatment with mirtazapine or placebo had no effect on cognitive and functional status as assessed by the M ini‐M ental S tate E xamination and the K atz scale, respectively. There were no differences between groups in the frequency or severity of the adverse events reported. Compared with the placebo group, mirtazapine users showed increased daytime sleepiness but no improvement in the duration or efficiency of nocturnal sleep after treatment. Conclusions: This study showed no significant therapeutic effects of 15‐mg mirtazapine in community‐dwelling A lzheimer's disease patients with sleep disorders. Instead, this study found evidence of worsening of daytime sleep patterns.

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Crossref · 10.1111/psyg.12191

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  • In double-blind randomized placebo-controlled trials for sleep consolidation in AD, melatonin, ramelteon, or mirtazapine use did not produce significant improvement on sleep measures.

    “While melatonin, ramelteon, or mirtazapine use did not produce significant improvement on sleep measures, trazodone, previously shown to enhance SWS by 50-56% on polysomnography in younger and older adults [10, 11], increased total sleep time by 42.5 minutes on actigraphy in patients with AD [12, 13].”

    From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [9]

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Research works printed but not linked: 33

  1. Ancoli‐Israel S, 1994, Sleep in non‐institutionalized Alzheimer's disease patients, Aging (Milano), 6, 451
  2. 10.1002/(SICI)1099-1166(1998100)13:10<682::AID-GPS847>3.0.CO;2-Y · DOI
  3. 10.1007/s11910-012-0249-8 · DOI
  4. 10.1093/sleep/27.8.1441 · DOI
  5. 10.1097/JCP.0b013e31825ddf3d · DOI
  6. 10.1016/j.jagp.2013.12.174 · DOI · Paper page
  7. 10.1358/dot.2010.46.3.1437247 · DOI
  8. 10.1590/S0004-282X2011000100010 · DOI
  9. 10.1093/sleep/25.6.666 · DOI · Paper page
  10. 10.4088/JCP.08m04234 · DOI
  11. 10.1185/030079903125002441 · DOI
  12. 10.1345/aph.10371 · DOI
  13. 10.2147/NDT.S3201 · DOI
  14. APA, 1994, Diagnostic and Statistical Manual of Mental Disorders
  15. 10.5327/Z2447-2115201500020007 · DOI
  16. 10.1016/j.jalz.2011.03.005 · DOI · Paper page
  17. 10.1212/WNL.44.12.2308 · DOI · Paper page
  18. 10.1177/0891988703255684 · DOI
  19. 10.1016/0022-3956(75)90026-6 · DOI · Paper page
  20. 10.1192/bjp.140.6.566 · DOI · Paper page
  21. 10.1016/0006-3223(88)90038-8 · DOI · Paper page
  22. 10.1111/j.1532-5415.1983.tb03391.x · DOI
  23. 10.1016/S0165-0327(98)00224-9 · DOI
  24. 10.1177/0269881107083808 · DOI
  25. 10.2165/11319480-000000000-00000 · DOI
  26. 10.1016/j.ejphar.2014.10.032 · DOI
  27. 10.1111/j.1527-3458.2001.tb00198.x · DOI
  28. 10.4088/JCP.v64n0106 · DOI
  29. 10.4088/JCP.v67n0313 · DOI
  30. 10.1002/gps.1589 · DOI
  31. 10.1097/WAD.0b013e3182614f52 · DOI
  32. 10.1002/pst.1589 · DOI
  33. 10.1016/j.smrv.2013.01.006 · DOI

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Metadata

Authors
Scoralick, F. M., Louzada, L. L., Quintas, J. L., Naves, J. O. S., Camargos, E. F., & Nóbrega, O. T.
Affiliations
  • Universidade de Brasília (BR)
  • Graduate Program in Medical Sciences University of Brasilia Brasília Brazil
ORCID
Venue
Psychogeriatrics
Publisher
Wiley
Published
2016-01-27
Volume
17
Issue
2
Pages
89-96
ISSN
  • 1346-3500 (ISSN-L)
  • 1479-8301
DOI
10.1111/psyg.12191
OpenAlex
W2256264485
Cited by
62
References
1
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 14 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 2
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Psychogeriatrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
CNPq (550315/2008-0, 310157/2012-9)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
mirtazapine, Alzheimer's disease, sleep disorders, daytime sleepiness, nocturnal sleep, actigraphy, cognitive function, functional status, adverse events, community-dwelling patients
MeSH terms
Mirtazapine, Aged, Aged, 80 and over, Alzheimer Disease, Antidepressive Agents, Tricyclic, Brazil, Double-Blind Method, Female, Humans, Male, Mianserin, Neuropsychological Tests, Pilot Projects, Sleep Wake Disorders, Treatment Outcome, Actigraphy

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