Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice
Open accessAbstract
Background and objective: The mammalian target of rapamycin (mTOR) signalling pathway regulates immune responses, and promotes cell growth and differentiation. Inhibition of mTOR with rapamycin modulates allergic asthma, while the underlying molecular mechanisms remain elusive. Here, we demonstrate that rapamycin, effectively inhibits eosinophil differentiation, contributing to its overall protective role in allergic airway inflammation. Methods: Rapamycin was administered in a mouse model of ovalbumin‐induced allergic airway inflammation, and the eosinophil differentiation was analysed in vivo and in vitro. Results: Rapamycin significantly attenuated allergic airway inflammation and markedly decreased the amount of eosinophils in local airways, peripheral blood and bone marrow, independently of levels of interleukin‐5 (IL‐5). In vitro colony forming unit assay and liquid culture demonstrated that rapamycin directly inhibited IL‐5‐induced eosinophil differentiation. In addition, rapamycin reduced the production of IL‐6 and IL‐13 by eosinophils. Rapamycin was also capable of reducing the eosinophil levels in IL‐5 transgenic NJ.1638 mice, again regardless of the constitutive high levels of IL‐5. Interestingly, rapamycin inhibition of eosinophil differentiation in turn resulted in an accumulation of eosinophil lineage‐committed progenitors in bone marrow. Conclusions: Altogether these results clearly demonstrate a direct inhibitory role of rapamycin in eosinophil differentiation and function, and reemphasize the importance of rapamycin and possibly, mTOR, in allergic airway disease.
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Animal models suggest that rapamycin may prevent terminal differentiation of eosinophils.
“animal models suggest that rapamycin may prevent terminal differentiation of eosinophils28.”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [28]
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Cites
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works
Interleukin-5, eosinophils, and disease
Sanderson, C. (1992) · Blood · doi:10.1182/blood.v79.12.3101.bloodjournal79123101 · Cited by 972 · see citing works
Interleukin-5, eosinophils, and disease
Sanderson, C. (1992) · Blood · doi:10.1182/blood.v79.12.3101.3101 · Cited by 860 · see citing works
Immunoregulatory functions of mTOR inhibition
Thomson, A. W., Turnquist, H. R., & Raimondi, G. (2009) · Nature reviews. Immunology · doi:10.1038/nri2546 · Cited by 849 · see citing works
Eosinophilia in transgenic mice expressing interleukin 5.
Dent, L. A., Strath, M., Mellor, A. L., & Sanderson, C. J. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.5.1425 · Cited by 579 · see citing works
The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
Powell, J. D., & Delgoffe, G. M. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.002 · Cited by 487 · see citing works
Dyer, K. D., Moser, J., Czapiga, M., Siegel, S. J., Percopo, C. M., & Rosenberg, H. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4004 · Cited by 246 · see citing works
Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
Huang, J. Y., Nguyen-McCarty, M., Hexner, E. O., Danet-Desnoyers, G. A., & Klein, P. S. (2012) · Nature Medicine · doi:10.1038/nm.2984 · Cited by 214 · see citing works
Identification of eosinophil lineage–committed progenitors in the murine bone marrow
Iwasaki, H., Mizuno, S.-I., Mayfield, R., Shigematsu, H., Arinobu, Y., Seed, B., Gurish, M. F., Takatsu, K., & Akashi, K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050548 · Cited by 205 · see citing works
Shen, H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechele, T. L., O'Neill, K. R., Ansay, T., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3296 · Cited by 165 · see citing works
Self-citationPope, S. M., Fulkerson, P. C., Blanchard, C., Akei, H. S., Nikolaidis, N. M., Zimmermann, N., Molkentin, J. D., & Rothenberg, M. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m406037200 · Cited by 157 · see citing works
Yurchenko, E., Shio, M. T., Huang, T. C. T., Martins, M. D. S., Szyf, M., Levings, M., Olivier, M., & Piccirillo, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035572 · Cited by 127 · see citing works
Inman, M. D., Ellis, R., Wattie, J. N., Denburg, J. A., & O’Byrne, P. M. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.4.3622 · Cited by 123 · see citing works
Kim, B. S., Kim, I., Park, Y.-J., Kim, Y.-S., Kim, Y., Chang, W., Lee, Y. S., Kweon, M., Chung, Y., & Kang, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911756107 · Cited by 98 · see citing works
Jacobsen, E. A., Ochkur, S. I., Lee, N. A., & Lee, J. J. (2007) · Current Allergy and Asthma Reports · doi:10.1007/s11882-007-0026-y · Cited by 84 · see citing works
Rapamycin Attenuates Airway Hyperreactivity, Goblet Cells, and IgE in Experimental Allergic Asthma
Mushaben, E. M., Kramer, E. L., Brandt, E. B., Hershey, G. K. K., & Cras, T. D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102133 · Cited by 76 · see citing works
In Vivo and In Vitro Effects of SAR 943, a Rapamycin Analogue, on Airway Inflammation and Remodeling
Fujitani, Y., & Trifilieff, A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-455oc · Cited by 61 · see citing works
Yamaki, K., & Yoshino, S. (2012) · Allergy · doi:10.1111/all.12000 · Cited by 60 · see citing works
Meng, Q., Ying, S., Corrigan, C. J., Wakelin, M., Assoufi, B., Moqbel, R., & Kay, A. B. (1997) · Allergy · doi:10.1111/j.1398-9995.1997.tb00181.x · Cited by 41 · see citing works
Shen, H., O’Byrne, P. M., Ellis, R., Wattie, J. N., Tang, C., & Inman, M. D. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2008161 · Cited by 41 · see citing works
Self-citationParadoxical Effects of Rapamycin on Experimental House Dust Mite-Induced Asthma
Fredriksson, K., Fielhaber, J. A., Lam, J., Yao, X., Meyer, K. S., Keeran, K. J., Nugent, G. Z., Qu, X., Yu, Z., Moss, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033984 · Cited by 34 · see citing works
Ben, S., Li, X., Xu, F., Xu, W., Li, W., Wu, Z., Huang, H., Shi, H., & Shen, H. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01747.x · Cited by 31 · see citing works
Self-citationTian, B., Hua, W., Xia, L., Jin, Y., Lan, F., Lee, J. J., Lee, N. A., Li, W. J., Ying, S., Chen, Z., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0097oc · Cited by 26 · see citing works
Self-citationEynott, P. R., Salmon, M., Huang, T., Oates, T., Nicklin, P. L., & Chung, K. F. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01672.x · Cited by 25 · see citing works
Geest, C. R., Zwartkruis, F. J. T., Vellenga, E., Coffer, P. J., & Buitenhuis, M. (2009) · Haematologica · doi:10.3324/haematol.13766 · Cited by 18 · see citing works
Huang, T., Eynott, P. R., Salmon, M., Nicklin, P. L., & Chung, K. F. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01295-5 · Cited by 15 · see citing works
Tigani, B., Hannon, J. P., Schaeublin, E., Mazzoni, L., & Fozard, J. R. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0767-7 · Cited by 13 · see citing works
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Weichhart, T., Hengstschläger, M., & Linke, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3901 · Cited by 836 · see citing works
Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S. J., James, A. L., Jenkins, C. R., Peters, M. J., Marks, G. B., Baraket, M., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31281-3 · Cited by 662 · see citing works
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging
Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544 · see citing works
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Wang, J., Zhou, Y., Zhang, H., Hu, L., Liu, J., Wang, L., Wang, T., Zhang, H., Cong, L., & Wang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01344-4 · Cited by 415 · see citing works
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Esfahani, K., Elkrief, A., Calabrese, C., Lapointe, R., Hudson, M., Routy, B., Miller, W. H., & Calabrese, L. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0352-8 · Cited by 351 · see citing works
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Jones, R. G., & Pearce, E. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.028 · Cited by 214 · see citing works
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Oliver, M., & Hinks, T. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2163 · Cited by 176 · see citing works
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Sun, L., Fu, J., & Zhou, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01632 · Cited by 152 · see citing works
Ma, B., Athari, S. S., Nasab, E. M., & Zhao, L. (2021) · Inflammation · doi:10.1007/s10753-021-01466-3 · Cited by 135 · see citing works
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Barnes, P. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012518 · Cited by 114 · see citing works
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Germič, N., Frangež, Ž., Yousefi, S., & Simon, H. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0295-8 · Cited by 111 · see citing works
Esfahani, K., Al-Aubodah, T.-A., Thebault, P., Lapointe, R., Hudson, M., Johnson, N. A., Baran, D., Bhulaiga, N., Takano, T., Cailhier, J.-F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12628-1 · Cited by 109 · see citing works
Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis
Liu, L., Zhou, L., Wang, L., Zheng, P., Zhang, F., Mao, Z., Zhang, H., & Liu, H. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s417801 · Cited by 81 · see citing works
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Painter, J. D., Galle-Treger, L., & Akbari, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01337 · Cited by 79 · see citing works
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Yoo, E., Ojiaku, C. A., Sunder, K., & Panettieri, R. A. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0308tr · Cited by 78 · see citing works
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Chen, X., Miao, M., Zhou, M., Chen, J., Li, D., Zhang, L., Sun, A., Guan, M., Wang, Z., Liu, P., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04055-2 · Cited by 48 · see citing works
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Li, W., Wu, Y., Zhao, Y. F., Li, Z., Chen, H., Dong, L., Liu, H., Zhang, M., Wu, Y., Zhou, J.-S., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-213771 · Cited by 37 · see citing works
Self-citationSuzuki, Y., Aono, Y., Akiyama, N., Horiike, Y., Naoi, H., Horiguchi, R., Shibata, K., Hozumi, H., Karayama, M., Furuhashi, K., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2025571 · Cited by 34 · see citing works
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Xia, L.-X., Hua, W., Jin, Y., Tian, B.-P., Qiu, Z.-W., Zhang, C., Che, L.-Q., Zhou, H.-B., Wu, Y.-F., Huang, H.-Q., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.74 · Cited by 33 · see citing works
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Zhu, C., Xia, L., Li, F., Zhou, L., Weng, Q., Li, Z., Wu, Y., Mao, Y., Zhang, C., Wu, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25358-z · Cited by 23 · see citing works
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Wu, J., Zhong, W., Zhang, H., & Yin, Y. (2020) · Pediatric Allergy Immunology and Pulmonology · doi:10.1089/ped.2019.1088 · Cited by 6 · see citing works
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Aziz, S., Pellegrino, R., Buono, P., Creoli, M., Torre, D., Chiantese, C., Colucci, A., Casertano, M., Ciamarra, P., Federico, A., et al. (2025) · Clinical & Experimental Immunology · doi:10.1093/cei/uxaf039 · Cited by 6 · see citing works
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Weng, B., Li, Y., Feng, W., Yao, P., Wang, Q., Wang, Q., Wang, X., Li, Y., Li, L., & Wang, Q. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107152 · Cited by 2 · see citing works
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Zhang, F., Wang, W., Zhu, Y., Mao, Y., Wang, T., & Gao, P. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03101-x · Cited by 2 · see citing works
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Du, X., Wang, Y., Huang, J., Vigder, N., Jin, T., Liu, Z., Hua, W., Li, W., & Li, F. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117443 · Cited by 1 · see citing works
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Lin, Q., Ni, H., Zhang, J., & Ting, X. U. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s585368
- Authors
- Hua, W., Liu, H., Xia, L., Tian, B., Huang, H., Chen, Z., Ju, Z., Li, W., Chen, Z., & Shen, H.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- Department of Respiratory and Critical Care Medicine Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China
- Institute of Aging Research Hangzhou Normal University College of Medicine Hangzhou Zhejiang China
- Venue
- Respirology
- Publisher
- Wiley
- Published
- 2015-06-04
- Volume
- 20
- Issue
- 7
- Pages
- 1055-1065
- ISSN
- 1323-7799 (ISSN-L)
- 1440-1843
- OpenAlex
- W1711531405
- Cited by
- 54
- References
- 27
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 1
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Respirology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation for Distinguished Young Scholars of China (30825019)
- Key Program of National Natural Science Foundation of China (81130001)
- Program for Zhejiang Leading Team of S&T Innovation (2011R50016)
- National Key Technologies R&D Program for the 12th Five-year Plan (2012BAI05B01)
- National Nature Science Foundation of China (81100019)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- rapamycin, mTOR signaling, eosinophil differentiation, allergic airway inflammation, allergic asthma, ovalbumin-induced airway inflammation, IL-5, interleukin-6, IL-13, eosinophil progenitors, bone marrow, IL-5 transgenic mice
- MeSH terms
- Animals, Asthma, Cell Differentiation, Disease Models, Animal, Eosinophils, Hypersensitivity, Immunosuppressive Agents, Inflammation, Interleukins, Leukocyte Count, Mice, Inbred BALB C, Mice, Transgenic, Ovalbumin, Signal Transduction, Serine Proteinase Inhibitors, Sirolimus, Mice, TOR Serine-Threonine Kinases
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