A re‐analysis of the 1968 Saltin et al. “Bedrest” paper
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In 1968, Saltin et al. published a landmark paper describing the alterations in VO 2max resulting from two sequential interventions – 20 days of bed rest and almost 8 weeks of training. They concluded that bed rest reduced VO 2max through reductions in maximal cardiac output, while training enhanced VO 2max by an equal combination of increased maximal cardiac output and increased arterio‐venous [O 2] difference (A‐V Δ [O 2]). At the time, A‐V Δ [O 2] was taken as an index of peripheral (skeletal muscle) adaptation. A key interpretive element that was not featured was consideration of how alterations in cardiac output affect the O 2 extraction process secondary to changes in red cell transit time through the muscle microcirculation, even in the absence of adaptive changes in the skeletal muscles per se. For the 2015 Saltin Symposium, it was therefore thought appropriate to re‐examine the 1968 O 2 transport data and re‐evaluate the roles central cardiovascular and peripheral muscle changes after bed rest and training allowing for their interaction. The analysis supports the conclusion that bed rest reduced VO 2max mainly through reduction in cardiac output, but after training, it is proposed that the 1968 conclusions should be modified: the majority of the increase in VO 2max from the control state can be attributed to an improvement in diffusive unloading of O 2 from the muscle microcirculation, with a much smaller role for enhanced blood flow.
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The restoration of VO2max after bed rest is partially explained by increased cardiac output.
“This partially explains the restoration of VO 2 max (142).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [142]
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Cites
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Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.
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- Authors
- Wagner, P. D.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Wagner, P. D.
- ORCID
- Wagner, P. D.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2015-11-19
- Volume
- 25
- Issue
- S4
- Pages
- 83-87
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W2179347928
- Cited by
- 10
- References
- 11
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2016: 2
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- bed rest, VO2max, maximal cardiac output, arteriovenous oxygen difference, muscle microcirculation, muscle blood flow, exercise training, oxygen transport
- MeSH terms
- Adaptation, Physiological, Bed Rest, Cardiac Output, Humans, Microcirculation, Oxygen, Oxygen Consumption, Muscle, Skeletal, Physical Conditioning, Human
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