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Cited by 35Breast Cancer Treatment StudiesBreast Lesions and CarcinomasWomen's cancer prevention and management

Timing of breast cancer surgery-how much does it matter?

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Mansfield, Sara A., Abdel-Rasoul, Mahmoud, Terando, Alicia M., Agnese, Doreen M.·2017·The Breast Journal
DOI 10.1111/tbj.12758
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Abstract

Timing of surgical resection after breast cancer diagnosis is dependent on a variety of factors. Lengthy delays may lead to progression; however, the impact of modest delays is less clear. The aim of this study was to evaluate the impact of surgical timing on outcomes, including disease-free survival (DFS) and nodal status (NS). The cancer registry from one academic cancer hospital was retrospectively reviewed. Time from initial biopsy to surgical resection was calculated for patients with ductal carcinoma in situ (DCIS) and stage 1 and 2 invasive carcinomas. Early (0-21 days), intermediate (22-42 days), and late (43-63 days) surgery groups were evaluated for differences in NS and DFS for each cancer stage separately. A total of 3,932 patients were identified for analysis. There were no differences in DFS noted for DCIS. For stage 1, early surgery (ES) was associated with worse DFS compared to intermediate surgery (IS) (p = 0.025). There were no significant differences between ES and late surgery (LS) (p = 0.700) or IS and LS (p = 0.065). In stage II cancers, there was a significant difference in DFS in ES compared to IS (p < 0.001) and LS (p = 0.009). There was no significant difference between IS and LS (p = 0.478). Patients were more likely to undergo immediate reconstruction (p < 0.0001 for all stages) in later time-to-surgery groups, while patients in earlier groups were more likely to undergo breast conserving surgery. There was also no significant difference in NS at time of surgery in clinical stage 1 (p = 0.321) or stage 2 disease (p = 0.571). Delays of up to 60 days were not associated with worse outcomes. This study should reassure patients and surgeons that modest delays do not adversely affect breast cancer outcomes. This allows patients time to consider treatment and reconstruction options.

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  1. Patrone MV, Hubbs JL, Bailey JE, Marks LB. How long have I had my cancer, doctor? Estimating tumor age via Collins' law. Oncology 2011; 25: 38-43, 46.

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Authors
Mansfield, S. A., Abdel-Rasoul, M., Terando, A. M., & Agnese, D. M.
Affiliations
  • The Ohio State University (US)
  • Center for Biostatistics; The Ohio State University College of Medicine; Columbus Ohio
Corresponding author
Agnese, Doreen M.
ORCID
Venue
The Breast Journal
Publisher
Wiley
Published
2017-01-24
Volume
23
Issue
4
Pages
444-451
ISSN
1075-122X (ISSN-L)
DOI
10.1111/tbj.12758
OpenAlex
W2580236242
Cited by
35
References
30
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 17 · 2017: 2
FWCI
1.74
Type
journal article
Language
en
Open access
Licence
Locations
  • The Breast Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (T32-CA090223)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords
ductal carcinoma in situ, early breast cancer, disease-free survival, lymph node status, breast reconstruction, breast-conserving surgery, delayed surgery
MeSH terms
Aged, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Female, Humans, Lymphatic Metastasis, Middle Aged, Waiting Lists, Carcinoma, Ductal, Breast, Disease-Free Survival

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