A case of pan‐resistant Burkholderia cepacia complex bacteremic pneumonia, after lung transplantation treated with a targeted combination therapy
Open accessAbstract
We describe a case of one patient with cystic fibrosis who developed a pan‐resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The patient was treated with a targeted combination antibiotic therapy (meropenem plus ceftazidime/avibactam plus high doses of nebulized colistimethate sodium). Evolution of the disease was complicated by multiple organ system dysfunction. Finally, clinical improvement and microbiological cure was achieved.
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Patients with B. cepacia complex may be candidates at specialized centers that have attained satisfactory outcomes with protocols implementing newer antibiotic combinations and intense management of sinusitis.
“patients may be candidates at specialized centers that have attained satisfactory outcomes with protocols implementing newer antibiotic combinations and intense management of sinusitis.(74–77)”
From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [76]
The Discussion reports that BCC infection is not an absolute contraindication to lung transplantation, that individual centers can determine their practice, and that one patient was cured with a targeted antibiotic combination. It does not report satisfactory outcomes from specialized-center protocols or intensive management of sinusitis; the case history mentions chronic rhinosinusitis but not its intensive treatment. (LLM, conf=0.87)
Experimental — accuracy not yet measuredSafe lung transplantation is possible in patients with hepatitis B virus if appropriate antiviral agents are used after transplantation.
“Safe lung transplantation is also possible in patients with hepatitis B virus, similarly to the transplantation of other solid organs, if appropriate antiviral agents are used after transplantation [30].”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [30]
The case report describes lung transplantation in a patient with cystic fibrosis and subsequent treatment of Burkholderia cepacia complex pneumonia (Abstract and Discussion; page numbers unavailable). Its mention of post-transplant antiviral prophylaxis does not address hepatitis B. Searches for hepatitis B, HBV, and antiviral treatment in transplant recipients found no passage supporting the claim. (LLM, conf=0.78)
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Orens, J. B., Estenne, M., Arcasoy, S., Conte, J. V., Corris, P., Egan, J. J., Egan, T., Keshavjee, S., Knoop, C., Kotloff, R., et al. (2006) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2006.03.011 · Cited by 1,073 · see citing works
Pseudomonas cepacia infection in cystic fibrosis: An emerging problem
Isles, A. F., MacLusky, I., Corey, M. L., Gold, R., Prober, C. G., Fleming, P. C., & Levison, H. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80993-2 · Cited by 846 · see citing works
Systematic Review and Meta-Analysis of In Vitro Synergy of Polymyxins and Carbapenems
Zusman, O., Avni, T., Leibovici, L., Adler, A., Friberg, L. E., Stergiopoulou, T., Carmeli, Y., & Paul, M. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01230-13 · Cited by 234 · see citing works
Boisson, M., Jacobs, M., Grégoire, N., Gobin, P., Marchand, S., Couet, W. R., & Mimoz, O. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03510-14 · Cited by 211 · see citing works
Sousa, S. A., Ramos, C. G., & Leitão, J. H. (2010) · International Journal of Microbiology · doi:10.1155/2011/607575 · Cited by 133 · see citing works
Updated Version of the Burkholderia cepacia Complex Experimental Strain Panel
Coenye, T., Vandamme, P. A. R., LiPuma, J. J., Govan, J. R. W., & Mahenthiralingam, E. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.6.2797-2798.2003 · Cited by 102 · see citing works
Stephenson, A. L., Sykes, J., Berthiaume, Y., Singer, L. G., Aaron, S. D., Whitmore, G. A., & Stanojevic, S. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.05.003 · Cited by 102 · see citing works
Tulkens, P. M. (2005) · Digital Access to Libraries · Cited by 98 · see citing works
Pankey, G. A., & Ashcraft, D. S. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.7.2959-2964.2005 · Cited by 79 · see citing works
Papp‐Wallace, K. M., Becka, S. A., Zeiser, E. T., Ohuchi, N., Mojica, M. F., Gatta, J. A., Falleni, M., Tosi, D., Borghi, E., Winkler, M., et al. (2017) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00020 · Cited by 76 · see citing works
Chakhtoura, N. G. E., Saade, E. A., Wilson, B. M., Pérez, F., Papp‐Wallace, K. M., & Bonomo, R. A. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix559 · Cited by 67 · see citing works
Gaibani, P., Lewis, R. E., Volpe, S. L., Giannella, M., Campoli, C., Landini, M. P., Viale, P., Re, M. C., & Ambretti, S. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.09.017 · Cited by 55 · see citing works
Rizk, N., Kanafani, Z. A., Tabaja, H., & Kanj, S. S. (2017) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1348894 · Cited by 32 · see citing works
Jacobs, D. M., DiTursi, S., Ruh, C. A., Sharma, R., Claus, J. A., Banjade, R., & Rao, G. G. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.06.002 · Cited by 24 · see citing works
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Leard, L. E., Holm, A. M., Valapour, M., Glanville, A. R., Attawar, S., Aversa, M., Campos, S. V., Christon, L. M., Cypel, M., Dellgren, G., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.07.005 · Cited by 821 · see citing works
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Yahav, D., Giske, C. G., Grāmatniece, A., Abodakpi, H., Tam, V. H., & Leibovici, L. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00115-20 · Cited by 538 · see citing works
Early clinical experience of bacteriophage therapy in 3 lung transplant recipients
Aslam, S., Courtwright, A., Koval, C. E., Lehman, S. M., Morales, S., Furr, C.-L. L., Rosas, F., Brownstein, M., Fackler, J. R., Sisson, B. M., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15503 · Cited by 285 · see citing works
Karakonstantis, S., Kritsotakis, E. I., & Gikas, A. I. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz401 · Cited by 150 · see citing works
Soriano, À., Carmeli, Y., Omrani, A. S., Moore, L. S. P., Tawadrous, M., & Irani, P. M. (2021) · Infectious Diseases and Therapy · doi:10.1007/s40121-021-00507-6 · Cited by 100 · see citing works
Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation
Coiffard, B., Prud’Homme, E., Hraiech, S., Cassir, N., Pavec, J. L., Kessler, R., Meloni, F., Léone, M., Thomas, P. A., Reynaud‐Gaubert, M., et al. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1151-9 · Cited by 34 · see citing works
Becka, S. A., Zeiser, E. T., LiPuma, J. J., & Papp‐Wallace, K. M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01332-21 · Cited by 28 · see citing works
Current trends in candidate selection, contraindications, and indications for lung transplantation
Arjuna, A., Olson, M. T., & Walia, R. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-2021-09 · Cited by 26 · see citing works
Mitchell, A. B., & Glanville, A. R. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1728797 · Cited by 12 · see citing works
Indications for Lung Transplantation and Patient Selection
Son, J., & Shin, C. (2022) · Journal of Chest Surgery · doi:10.5090/jcs.22.057 · Cited by 9 · see citing works
Bassetti, M., Cardone, A., Cardoso, F., Carter, V., Cornely, O. A., Falcone, M., Gallego, D., Giannella, M., Grossi, P., Pagano, L., et al. (2025) · Infectious Diseases and Therapy · doi:10.1007/s40121-025-01204-4 · Cited by 7 · see citing works
Wang, L., Liu, J., & Peng, L. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s393647 · Cited by 6 · see citing works
Comparative Metagenomic Profiling of Seed-Borne Microbiomes in a Landrace and a Hybrid Maize Variety
Henaut-Jacobs, S., Cyríaco, B. E. B., Pedrosa‐Silva, F., Olivares, F. L., & Venâncio, T. M. (2024) · Seeds · doi:10.3390/seeds3040035 · Cited by 5 · see citing works
Fratoni, A. J., Gethers, M. L., Nicolau, D. P., & Kuti, J. L. (2025) · Clinical Infectious Diseases · doi:10.1093/cid/ciaf403 · Cited by 2 · see citing works
Multiresistant organisms: bacteria and beyond
Solé, A. (2022) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000976 · Cited by 1 · see citing works
Sato, M., Honda, A., Maki, H., Toyama, K., Yamaguchi, R., Ikeda, M., Moriya, K., & Kurokawa, M. (2021) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2021.08.023
Lung Transplantation: Recipient Selection
Glanville, A. R., & Ainge‐Allen, H. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00082-2
Amelina, E., Krasovskiy, S., & Melikhov, O. G. (2022) · PULMONOLOGIYA · doi:10.18093/0869-0189-2022-32-5-737-744
Dealing with Difficult Bugs Before Lung Transplantation
Mehta, N., Lyon, G. M., & Pouch, S. M. (2024) · Organ and tissue transplantation · doi:10.1007/978-3-319-20788-9_16-1
Dealing with Difficult Bugs Before Lung Transplantation
Mehta, N., Lyon, G. M., & Pouch, S. M. (2024) · Organ and tissue transplantation · doi:10.1007/978-3-030-36123-5_16
Lombardi, A., Mangioni, D., Viero, G., Alagna, L., Renisi, G., Saltini, P., & Bandera, A. (2026) · Transplant International · doi:10.3389/ti.2026.15264
- Authors
- Cantón‐Bulnes, M. L., Hurtado Martínez, Á., López‐Cerero, L., Arenzana Seisdedos, Á., Merino‐Bohorquez, V., & Garnacho‐Montero, J.
- Affiliations
- Hospital Universitario Virgen Macarena (ES)
- Unidad de Cuidados Intensivos, Hospital Universitario Virgen Macarena Sevilla Spain
- Servicio de Farmacia Hospital Universitario Virgen Macarena Sevilla Spain
- Corresponding author
- Cantón‐Bulnes, María Luisa
- Venue
- Transplant Infectious Disease
- Publisher
- Wiley
- Published
- 2019-01
- Volume
- 21
- Issue
- 2
- Pages
- e13034-e13034
- ISSN
- 1398-2273 (ISSN-L)
- 1399-3062
- OpenAlex
- W2904599441
- Semantic Scholar
- 8f94f7ef96974e4fa366b95944322de417b97cba
- Cited by
- 21
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Transplant Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Epidemiology › Burkholderia infections and melioidosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Burkholderia cepacia complex, pan-resistant bacteria, lung transplantation, cystic fibrosis, meropenem, ceftazidime-avibactam, combination antibiotic therapy, multiple organ failure
- MeSH terms
- Adult, Anti-Bacterial Agents, Colistin, Cystic Fibrosis, Humans, Male, X-Rays, Lung Transplantation, Bacteremia, Treatment Outcome, Pneumonia, Bacterial, Burkholderia Infections, Drug Resistance, Multiple, Bacterial, Burkholderia cepacia complex
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