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The single‐subunit RING‐type E3 ubiquitin ligase RSL 1 targets PYL 4 and PYR 1 ABA receptors in plasma membrane to modulate abscisic acid signaling
Open accessAbstract
Summary: Membrane‐delimited events play a crucial role for ABA signaling and PYR/PYL/RCAR ABA receptors, clade A PP 2Cs and Sn RK 2/CPK kinases modulate the activity of different plasma membrane components involved in ABA action. Therefore, the turnover of PYR/PYL/RCAR s in the proximity of plasma membrane might be a step that affects receptor function and downstream signaling. In this study we describe a single‐subunit RING‐type E3 ubiquitin ligase RSL 1 that interacts with the PYL 4 and PYR 1 ABA receptors at the plasma membrane. Overexpression of RSL 1 reduces ABA sensitivity and rsl1 RNA i lines that impair expression of several members of the RSL 1/RFA gene family show enhanced sensitivity to ABA. RSL 1 bears a C‐terminal transmembrane domain that targets the E3 ligase to plasma membrane. Accordingly, bimolecular fluorescent complementation (Bi FC) studies showed the RSL 1–PYL 4 and RSL 1–PYR 1 interaction is localized to plasma membrane. RSL 1 promoted PYL 4 and PYR 1 degradation in vivo and mediated in vitro ubiquitylation of the receptors. Taken together, these results suggest ubiquitylation of ABA receptors at plasma membrane is a process that might affect their function via effect on their half‐life, protein interactions or trafficking.
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Cites
Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80455-4 · Cited by 453
Cited by
Mechanisms of abscisic acid-mediated control of stomatal aperture
Munemasa, S., Hauser, F., Park, J., Waadt, R., Brandt, B., & Schroeder, J. I. (2015) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.10.010 · Cited by 567
E3 Ubiquitin Ligases: Ubiquitous Actors in Plant Development and Abiotic Stress Responses
Shu, K., & Yang, W. (2017) · Plant and Cell Physiology · doi:10.1093/pcp/pcx071 · Cited by 322
Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases
Kong, L., Cheng, J., Zhu, Y., Ding, Y., Meng, J., Chen, Z., Xie, Q., Guo, Y., Li, J., Yang, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9630 · Cited by 316
Revisiting the Basal Role of ABA – Roles Outside of Stress
Yoshida, T., Christmann, A., Yamaguchi-Shinozaki, K., Grill, E., & Fernie, A. R. (2019) · Trends in Plant Science · doi:10.1016/j.tplants.2019.04.008 · Cited by 268
Chen, S., Zhang, N., Zhou, G., Hussain, S., Ahmed, S., Tian, H., & Wang, S. (2021) · BMC Plant Biology · doi:10.1186/s12870-021-02907-9 · Cited by 109
Metadata
- Authors
- Bueso, E., Rodriguez, L., Lorenzo‐Orts, L., Gonzalez‐Guzman, M., Sayas, E., Muñoz‐Bertomeu, J., Ibañez, C., Serrano, R., & Rodriguez, P. L.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2014-12
- Volume
- 80
- Issue
- 6
- Pages
- 1057-1071
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W1972192214
- Cited by
- 196
- References
- 1
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The single‐subunit RING‐type E3 ubiquitin ligase RSL 1 targets PYL 4 and PYR 1 ABA receptors in plasma membrane to modulate abscisic acid signaling. https://app.cochat.ai/papers/10.1111/tpj.12708
- The paper
- Bueso, E., Rodriguez, L., Lorenzo‐Orts, L., Gonzalez‐Guzman, M., Sayas, E., Muñoz‐Bertomeu, J., Ibañez, C., Serrano, R., & Rodriguez, P. L. (2014). The single‐subunit RING‐type E3 ubiquitin ligase RSL 1 targets PYL 4 and PYR 1 ABA receptors in plasma membrane to modulate abscisic acid signaling. The Plant Journal. https://doi.org/10.1111/tpj.12708
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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