The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mechanisms of red blood cell transfusion‐related immunomodulation
Open accessAbstract
Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma patients in whom both systemic inflammation and immune suppression are associated with adverse outcomes. RBC products contain a multitude of immunomodulatory mediators that interact with and alter immune cell function. These interactions can lead to both proinflammatory and immunosuppressive effects. Defining clinical outcomes related to immunomodulatory effects of RBCs in transfused patients remains a challenge, likely due to complex interactions between individual blood product characteristics and patient‐specific risk factors. Unpacking these complexities requires an in‐depth understanding of the mechanisms of immunomodulatory effects of RBC products. In this review, we outline and classify potential mediators of RBC transfusion‐related immunomodulation and provide suggestions for future research directions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?
Vamvakas, E. C., & Blajchman, M. A. (2001) · Blood · doi:10.1182/blood.v97.5.1180 · Cited by 423 · cited 4×
“Nonetheless, RBC transfusion may have deleterious immunologic effects, particularly for critically ill patients.(13,14) Mounting evidence from predominantly”
BackgroundInfluentialThe Role of Iron in the Immune Response to Bacterial Infection
Cherayil, B. J. (2011) · Immunologic Research · doi:10.1007/s12026-010-8199-1 · Cited by 191
Porto, B. N., Alves, L. S., Fernández, P. L., Dutra, T. P., Figueiredo, R. T., Graça-Souza, A. V., & Bozza, M. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703570200 · Cited by 161
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages
Liang, X., Lin, T., Sun, G., Beasley-Topliffe, L., Cavaillon, J.-M., & Warren, H. S. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208742 · Cited by 106
Theurl, I., Fritsche, G., Ludwiczek, S., Garimorth, K., Bellmann-Weiler, R., & Weiss, G. (2005) · BioMetals · doi:10.1007/s10534-005-3710-1 · Cited by 72
Long, K., Meier, C., Bernard, A., Williams, D., Davenport, D., & Woodward, J. (2014) · Transfusion · doi:10.1111/trf.12472 · Cited by 29
Cited by
Haptoglobin improves shock, lung injury, and survival in canine pneumonia
Remy, K. E., Cortés-Puch, I., Solomon, S. B., Sun, J., Pockros, B. M., Feng, J., Lertora, J. J., Hantgan, R. R., Liu, X., Perlegas, A., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.123013 · Cited by 49
Self-citationHuang, H., Zhu, J., Fan, L., Lin, Q., Fu, D., Wei, B., & Wei, S. (2019) · BioMed Research International · doi:10.1155/2019/2045915 · Cited by 33
Metadata
- Authors
- Remy, K. E., Hall, M. W., Cholette, J., Juffermans, N. P., Nicol, K., Doctor, A., Blumberg, N., Spinella, P. C., Norris, P. J., Dahmer, M. K., Muszynski, J. A., & for the Pediatric Critical Care Blood Research Network (Blood Net)
- Venue
- Transfusion
- Publisher
- Wiley
- Published
- 2018-01-30
- Volume
- 58
- Issue
- 3
- Pages
- 804-815
- ISSN
- 0041-1132 (ISSN-L)
- 1537-2995
- OpenAlex
- W2792721781
- Cited by
- 245
- References
- 9
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
