The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index; none of the 38 sources its claims cite is checked for support yet.
A clinical trial of Integra Template for diabetic foot ulcer treatment
Open accessAbstract
Individuals with diabetes mellitus are at an increased risk of developing a diabetic foot ulcer (DFU). This study evaluated the safety and efficacy of Integra Dermal Regeneration Template (IDRT) for the treatment of nonhealing DFUs. The Foot Ulcer New Dermal Replacement Study was a multicenter, randomized, controlled, parallel group clinical trial conducted under an Investigational Device Exemption. Thirty‐two sites enrolled and randomized 307 subjects with at least one DFU. Consented patients were entered into the 14‐day run‐in phase where they were treated with the standard of care (0.9% sodium chloride gel) plus a secondary dressing and an offloading/protective device. Patients with less than 30% reepithelialization of the study ulcer after the run‐in phase were randomized into the treatment phase. The subjects were randomized to the control treatment group (0.9% sodium chloride gel; n = 153) or the active treatment group (IDRT, n = 154). The treatment phase was 16 weeks or until confirmation of complete wound closure (100% reepithelialization of the wound surface), whichever occurred first. Following the treatment phase, all subjects were followed for 12 weeks. Complete DFU closure during the treatment phase was significantly greater with IDRT treatment (51%) than control treatment (32%; p = 0.001) at sixteen weeks. The median time to complete DFU closure was 43 days for IDRT subjects and 78 days for control subjects in wounds that healed. The rate of wound size reduction was 7.2% per week for IDRT subjects vs. 4.8% per week for control subjects ( p = 0.012). For the treatment of chronic DFUs, IDRT treatment decreased the time to complete wound closure, increased the rate of wound closure, improved components of quality of life and had less adverse events compared with the standard of care treatment. IDRT could greatly enhance the treatment of nonhealing DFUs.
Overview
CoChat Summary
TL;DR
In the FOUNDER multicenter randomized trial, Integra Dermal Regeneration Template (IDRT) significantly increased complete closure of chronic diabetic foot ulcers compared with standard of care. IDRT also reduced time to closure and improved some quality-of-life measures, with fewer severe adverse events.
Key findings
- Complete DFU closure during the 16-week treatment phase was 51% (79/154) with IDRT vs 32% (49/153) with control (p = 0.001); by blinded computerized planimetry, closure was 50% vs 31% (p = 0.001).
- Median time to complete closure among healed wounds was 43 days for IDRT vs 78 days for control; wound size reduction was 7.2% per week vs 4.8% per week (p = 0.012).
- At 12 weeks, complete closure was 45% (70/154) with IDRT vs 20% (31/153) with control (p < 0.001), with an odds ratio of 3.3 (95% CI 2.0, 5.4).
- Severe adverse events occurred in 15.6% of IDRT subjects vs 26.8% of control subjects (p = 0.016); quality-of-life improvements were significant for Physical Functioning (p = 0.047) and Bodily Pain (p = 0.033).
Methods
- Multicenter, randomized, controlled, parallel-group trial under an Investigational Device Exemption at 32 sites; 307 subjects with nonhealing DFUs were randomized 1:1 to IDRT (n = 154) or control saline gel standard of care (n = 153) after a 14-day run-in in which only ulcers with less than 30% reepithelialization were randomized.
- Treatment phase lasted up to 16 weeks or until confirmed complete wound closure, followed by a 12-week follow-up; the primary endpoint was investigator-assessed complete closure during the treatment phase, with blinded central computerized planimetry as a secondary assessment.
- Efficacy analyses used the intent-to-treat cohort; primary outcome used logistic regression adjusted for baseline ulcer size strata, with secondary outcomes analyzed by Cox regression, linear mixed-effects models, and closed testing to maintain type I error at 0.05.
Limitations
- The paper states that the study was not double-blinded, a limitation it notes applies to this and other DFU studies involving cellular and/or tissue-based products; it reports that this bias was addressed by third-party blinded computerized planimetry.
- The paper states that strict inclusion/exclusion criteria could affect generalizability, though it argues this was minimized by enrolling from 32 academic and private practice sites across the United States.
- Evident from the text: the study was sponsored and funded by Integra LifeSciences Corporation, and multiple authors report grants, personal fees, or nonfinancial support from Integra, which is not framed by the authors as a limitation.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
0 Valid · 0 Not valid · 19 Not checked · 53 Own results and interpretations
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cell-based products also need multiple reapplications in treating a DFU whereas this study demonstrated that reapplications of IDRT are generally not necessary.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > DISCUSSION
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Complete DFU closure during the treatment phase was significantly greater with IDRT treatment (51%) than control treatment (32%; p 5 0.001) at sixteen weeks.”
- Also stated in: § Study subjects · plain
“Complete closure of the study ulcer during the treatment phase (16 weeks), as defined by the investigator, was significantly greater in the active group (51%; 79/154) in comparison to the control group (32%; 49/153, p 5 0.001).”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Study subjects · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The median time to complete DFU closure was 43 days for IDRT subjects and 78 days for control subjects in wounds that healed.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The majority of AEs in both groups were mild.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Study subjects
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The rate of wound size reduction was 7.2% per week for IDRT subjects vs. 4.8% per week for control subjects (p 5 0.012).”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
42 more claims
Create a free account to see all 72 claims and every source verdict.
- Probably not a substantial claim. 13
- It may state two separate claims as one. 16
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although the final follow-up wound area was similar between two treatment groups, the percentage area reduction (PAR) was demonstrated to be significantly increased in several studies [23, 26, 27, 31, 34].”
From Effectiveness and safety of dermal matrix used for diabetic foot ulcer: a systematic review and meta-analysis of randomized controlled trials (2024) · cites this paper as [23]
Citations
Cites
Incidence, outcomes, and cost of foot ulcers in patients with diabetes.
Ramsey, S. D., Newton, K. M., Blough, D. K., McCulloch, D. K., Sandhu, N., Reiber, G. E., & Wagner, E. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.3.382 · Cited by 1,064
Design of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140108 · Cited by 1,044
Design of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140314 · Cited by 889
Risk Factors for Foot Infections in Individuals With Diabetes
Lavery, L. A., Armstrong, D. G., Wunderlich, R. P., Mohler, M. J., Wendel, C. S., & Lipsky, B. A. (2006) · Diabetes Care · doi:10.2337/dc05-2425 · Cited by 787
Self-citationWieman, T. J., Smiell, J. M., & Su, Y. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.822 · Cited by 683
Veves, A., Falanga, V., Armstrong, D. G., Sabolinski, M. L., & Study, T. A. D. F. U. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.290 · Cited by 643
Burden of Diabetic Foot Ulcers for Medicare and Private Insurers
Rice, J. B., Desai, U., Cummings, A. K. G., Birnbaum, H. G., Skornicki, M., & Parsons, N. B. (2014) · Diabetes Care · doi:10.2337/dc13-2176 · Cited by 624
The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers
Marston, W. A., Hanft, J., Norwood, P., Pollak, R., & for the Dermagraft Diabetic Foot Ulcer Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1701 · Cited by 613
Steed, D. L., & the Diabetic Ulcer Study Group * (1995) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(95)70245-8 · Cited by 610
Lower-Extremity Amputation in People With Diabetes: Epidemiology and Prevention
Bild, D. E., Selby, J. V., Sinnock, P., Browner, W. S., Braveman, P., & Showstack, J. A. (1989) · Diabetes Care · doi:10.2337/diacare.12.1.24 · Cited by 517
Research works printed but not linked: 3
- Boulton A, 2005, Diabetic foot and ulceration: epidemiology and pathophysiology
- Gibson D, 2009, MMPs made easy, Wound Int, 1, 1
- Gethin G, 2007, Wound measurement: the contribution to practice, EWMA J., 7, 26
Cited by
Items 101–200 of 290
Samsell, B. J., McLean, J. B., Cazzell, S. M., Dorsch, K., Moyer, P. M., & Moore, M. A. (2019) · Journal of Wound Care · doi:10.12968/jowc.2019.28.sup9.s14 · Cited by 23
Stack, M., Mishra, S., Ratnamani, M. P. C., Wang, H., Gold, L. I., & Wang, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c13887 · Cited by 23
SOCIOECONOMIC SECURITY OF A REGION AS AN OBJECT IN ECONOMIC SECURITY STUDIES AT THE MESOLEVEL
Kozachenko, A., & Bukolova Viktoriia, V. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-188-195 · Cited by 22
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
Pennec, J. L., Picart, C., Vivès, R. R., & Migliorini, E. (2023) · Advanced Materials · doi:10.1002/adma.202312154 · Cited by 21
Tissue-Engineered Wound Dressings for Diabetic Foot Ulcers
Rahmani, S., & Mooney, D. J. (2018) · Contemporary diabetes · doi:10.1007/978-3-319-89869-8_15 · Cited by 21
Krishnan, Y., & Sampath, S. (2025) · Discover Materials · doi:10.1007/s43939-025-00435-z · Cited by 20
Wu, S. S., Wells, M., Ascha, M., Gatherwright, J. R., & Chepla, K. J. (2022) · Journal of Hand and Microsurgery · doi:10.1055/s-0042-1749077 · Cited by 20
Kuang, B., Pena, G. N., Cowled, P., Fitridge, R., Greenwood, J. E., Wagstaff, M. J. D., & Dawson, J. A. (2022) · Scars Burns & Healing · doi:10.1177/20595131221122272 · Cited by 20
Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27601 · Cited by 20
Skin Grafting for Dermatologists: Past, Present, and Future
Bermudez, N. M., Brianna, C., Hargis, A., Yaghi, M., & Mervis, J. S. (2024) · Current Dermatology Reports · doi:10.1007/s13671-024-00427-x · Cited by 19
Chávez, J. C. P., McGrath, M., Kearney, C. J., Browne, S., & O’Brien, F. J. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100073 · Cited by 19
Shevchenko, H. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-1-109-115 · Cited by 19
Current Available Cellular and Tissue-Based Products for Treatment of Skin Defects
Liu, Y., Panayi, A. C., Bayer, L. R., & Orgill, D. P. (2018) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000547412.54135.b7 · Cited by 19
Paola, L. D., Cimaglia, P., Carone, A., Boscarino, G., & Scavone, G. (2020) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734620905741 · Cited by 19
Coye, T. L., Bargas-Ochoa, M., Zulbaran‐Rojas, A., Leal, B. M., Ouattas, A., Tarricone, A. N., Chung, J., Najafi, B., & Lavery, L. A. (2024) · Wound Repair and Regeneration · doi:10.1111/wrr.13237 · Cited by 18
Self-citationChronic Leg Ulcers: Are Tissue Engineering and Biomaterials Science the Solution?
Kyriakidis, C., Lali, F. V., Greco, K. V., & García‐Gareta, E. (2021) · Bioengineering · doi:10.3390/bioengineering8050062 · Cited by 18
Genetic Determinants of Wound Healing: Monogenic Disorders and Polygenic Influence
Mueller, S. M., Miller, N., Gill, J., Yu, L. C., PIKE, M. M., & Orgill, D. P. (2026) · Cells · doi:10.3390/cells15010074 · Cited by 17
Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review
Primous, N. R., Elvin, P. T., Carter, K. V., Andrade, H. L., Fontaine, J. L., Shibuya, N., & Biguetti, C. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051221 · Cited by 17
Banerjee, J., Lasiter, A., & Nherera, L. M. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0075 · Cited by 17
Cazzell, S. M., Caporusso, J., Vayser, D., Davis, R. D., Alvarez, O. M., & Sabolinski, M. L. (2024) · Journal of Wound Care · doi:10.12968/jowc.2024.0139 · Cited by 17
Sun, L., Wang, X., Deng, T., Luo, L., Lin, L., Yang, L., Tian, Y., Tian, Y., & Wu, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135708 · Cited by 17
Suku, M., Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm11010004 · Cited by 17
Fadilah, N. I. M., Riha, S. M., Mazlan, Z., Wen, A. P. Y., Hao, L. Q., Joseph, B., Maarof, M., Thomas, S., Motta, A., & Fauzi, M. B. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1160577 · Cited by 17
Lavery, L. A., Killeen, A. L., Farrar, D., Akgul, Y., Crisologo, P. A., Malone, M., & Davis, K. E. (2020) · International Wound Journal · doi:10.1111/iwj.13490 · Cited by 17
Self-citationSchindler, C., Mikosiński, J., Mikosiński, P., Kärkkäinen, H.-R., Sanio, M., Kurkipuro, J., Mierau, I., Smith, W., Vartiainen, A., Décory, L., et al. (2024) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188241294134 · Cited by 16
GLOBALIZATION AND ITS NEGATIVE IMPACT ON THE GLOBAL ECONOMY
Shopina, I. M., Oliinyk, O., & Finaheiev, V. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-457-461 · Cited by 16
Guest, J. F., Singh, H., & Vowden, P. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.3.136 · Cited by 16
Engineering tools for stimulating wound healing
Lazarus, E., Barnum, L., Ramesh, S., Quint, J. P., Samandari, M., Laflamme, S., Secord, T. W., Schmidt, T. A., Tamayol, A., & Rivero, I. V. (2024) · Applied Physics Reviews · doi:10.1063/5.0173663 · Cited by 15
Post-burn breast reconstruction using an artificial dermis—a long-term follow-up
Gronovich, Y., Lotan, A. M., & Retchkiman, M. (2016) · Burns & Trauma · doi:10.1186/s41038-016-0037-9 · Cited by 15
Huang, W., Chen, Y., Wang, N., Yin, G., Wei, C., & Xu, W. (2020) · Journal of Diabetes Research · doi:10.1155/2020/6245758 · Cited by 15
Sui, L., Xie, Q., Jiang, H.-T., & Li, X.-D. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01550-3 · Cited by 14
Experimental treatments in clinical trials for diabetic foot ulcers: wound healers in the pipeline
Sumpio, B. J., Mezghani, I., Wang, E., Li, Z., Valsami, E., Theocharidis, G., & Veves, A. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2178418 · Cited by 14
ANALYSIS OF THE SOCIO-ECONOMIC DEVELOPMENT OF UKRAINIAN REGIONS
Kozyrieva, O., Sagaidak-Nikituk, R., & Demchenko, N. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-2-51-58 · Cited by 14
Henn, D., Chen, K., Fischer, K. S., Rauh, A., Barrera, J. A., Kim, Y.-J., Martin, R. A., Hannig, M., Niedoba, P., Reddy, S., et al. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.0975 · Cited by 14
Guerriero, F. P., Clark, R. A., Miller, M., & Delaney, C. L. (2023) · Biomedicines · doi:10.3390/biomedicines11030721 · Cited by 14
Vascular leakage and angiogenesis in wound healing: a review
Wichaiyo, S. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10932-2 · Cited by 13
Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine
Lyu, J., Liu, X., Yang, Q., Zhang, Y., & Wang, X. (2026) · MedComm · doi:10.1002/mco2.70602 · Cited by 13
Adoption of a Newly Introduced Dermal Matrix: Preliminary Experience and Future Directions
Lisa, A. V. E., Galtelli, L., Vinci, V., Veronesi, A., Cozzaglio, L., Cananzi, F., Sicoli, F., & Klinger, M. E. A. (2020) · BioMed Research International · doi:10.1155/2020/3261318 · Cited by 13
Update of Topical Interventions for Healing Diabetic Ulcers—A Systematic Review
de Sousa, G. P., Fontenele, M. K. A., da Rocha, R. B., & Cardoso, V. S. (2021) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346211013189 · Cited by 13
Advanced dressings based on novel biological targets for diabetic wound healing: A review
Huang, L., Chen, H.-B., Nie, J., Zhao, Y., & Miao, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177201 · Cited by 12
Mukharya, A., Pokale, R., Roy, A. A., Soman, S., Kulkarni, S., Madhusoodanan, G., Manikkath, J., Farhana, S. A., Pandey, A. P., & Mutalik, S. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106590 · Cited by 12
Use of hyperspectral imaging to predict healing of diabetic foot ulceration
Kounas, K., Dinh, T., Riemer, K., Rosenblum, B. I., Veves, A., & Giurini, J. M. (2023) · Wound Repair and Regeneration · doi:10.1111/wrr.13071 · Cited by 12
Contemporary Medical Management of Peripheral Arterial Disease
Cook, I. O., & Chung, J. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07516-2 · Cited by 12
Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix
Barton, E. C., & Abicht, B. P. (2021) · Foot & Ankle Surgery Techniques Reports & Cases · doi:10.1016/j.fastrc.2021.100076 · Cited by 12
Physiology and Pathophysiology of Wound Healing in Diabetes
Pastar, I., Ojeh, N. O., Glinos, G. D., Stojadinović, O., & Tomic‐Canic, M. (2018) · Contemporary diabetes · doi:10.1007/978-3-319-89869-8_7 · Cited by 12
Shah, A., & Taupin, P. (2021) · Case Reports in Plastic Surgery and Hand Surgery · doi:10.1080/23320885.2021.2011289 · Cited by 12
Topical Wound Care Treatment and Indications for Their Use
Lantis, J. C., & Paredes, J. A. (2018) · Contemporary diabetes · doi:10.1007/978-3-319-89869-8_18 · Cited by 12
Li, J., Wang, M., Tan, X., Duanmiao, Y., Zheng, X., Wang, Z., Gao, F., Miao, Y., Li, H., Liu, B., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102005 · Cited by 11
Lavery, L. A., Tarricone, A. N., Reyes, M. C., Suludere, M. A., Sideman, M. J., Siah, M. C., Peters, E. J. G., & Wukich, D. K. (2024) · International Wound Journal · doi:10.1111/iwj.70072 · Cited by 11
Self-citationErbium: Yttrium Aluminum Garnet Laser Accelerates Healing in Indolent Diabetic Foot Ulcers
Johnson, M. J., Crisologo, P. A., Truong, D. H., Wukich, D. K., Öz, O. K., Fontaine, J. L., & Lavery, L. A. (2019) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2019.07.023 · Cited by 11
Self-citationMonjanel, B., Baillif, S., Lagier, J., Gastaud, L., Poissonnet, G., & Martel, A. (2021) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-021-05155-7 · Cited by 11
Sarkar, S., & Poundarik, A. A. (2021) · Materialia · doi:10.1016/j.mtla.2021.101269 · Cited by 11
Chronic Wound Healing: A Review of Current Management and Treatments
Jha, K. K., Raj, A., Shreyasi, S., Bishnoi, H., Raj, M., & Thakur, V. (2023) · Asian Journal of Pharmaceutical Research and Development · doi:10.22270/ajprd.v11i3.1262 · Cited by 11
Armstrong, D. G., Orgill, D. P., Galiano, R., Glat, P. M., Carter, M. J., Zelen, C. M., & Li, W. W. (2020) · International Wound Journal · doi:10.1111/iwj.13404 · Cited by 11
Collagen role in the mechanisms of chronic wounds healing diabetic foot syndrome.
Silina, E. V., Stupin, V. A., & Gabitov, R. (2018) · Clinical Medicine (Russian Journal) · doi:10.18821/0023-2149-2018-96-2-106-115 · Cited by 11
Wang, Y., Huang, X., Jiang, J., Meng, Q., Li, Y., Zhao, W., Chen, S., & Wu, S. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c14731 · Cited by 10
Bieliaieva, N. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-4-12-17 · Cited by 10
The Role of Dermal Regenerative Templates in Complex Lower Extremity Wounds
Henning, J. A., Liette, M. D., Laklouk, M., Fadel, M., & Masadeh, S. B. (2020) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2020.07.010 · Cited by 10
Prezzavento, G. E., Calvi, R. N. J., Rodriguez, J. A., & Taupin, P. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.7.612 · Cited by 10
Karimpour, S., Amirmotamed, M. H., Rashnoo, F., Tahmasebinia, F., Keramatinia, A., Fathabadi, F. F., Abbaszadeh, H., & Darabi, S. (2023) · Journal of lasers in medical sciences · doi:10.34172/jlms.2023.49 · Cited by 10
FDI AND FINANCIAL DEVELOPMENT AS DETERMINANTS OF ECONOMIC GROWTH FOR V4 COUNTRIES
Gural, A., & Lomachynska, I. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-4-59-64 · Cited by 10
RELEVANT PROBLEMS OF UKRAINE’S INTEGRATION INTO GLOBAL ECONOMY
Duliba, Y., & Ilkiv, O. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-146-150 · Cited by 10
Luong, D., Weisel, A., Cohen, R., Spector, J. A., & Sapir, Y. (2023) · Wound Repair and Regeneration · doi:10.1111/wrr.13102 · Cited by 9
Tailored bioengineering and nanomedicine strategies for sex-specific healing of chronic wounds
Mahmoudi, N., Sharifi, S., Leshchiner, D. R., Horibata, S., Lin, Z., Ghazali, N., Shahbazi, M., Priyam, A., Williams, R. J., Pastar, I., et al. (2024) · British Journal of Dermatology · doi:10.1093/bjd/ljae457 · Cited by 9
Composite Hyaluronic Acid Gas-Entrapping Materials to Promote Wound Healing
Witt, E., Petersen, E. B., Alzayadneh, E., Courtney, R. J., Brouillette, M. J., Wang, Q., Sakyi, M. Y., Watson, N. A. D., Rivas, D. J. L., Bi, J., et al. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c00904 · Cited by 9
Tibatan, M. A., Katana, D., & Yin, C. M. (2024) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2024.2402148 · Cited by 9
Pacaccio, D. J., Cazzell, S. M., Halperin, G. J., Kasper, M. A., Neutel, J. M., O'Carroll, B. D., & Reyzelman, A. M. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.sup7.s28 · Cited by 9
Self-citationTranslation and validation of the Persian version of diabetic foot ulcer scaleshort form ( DFS‐SF )
Tavassolmand, S. S., Montazeri, A., Madadizadeh, F., Dehghan, H., Ranjbar, M., & Ameri, H. (2022) · International Wound Journal · doi:10.1111/iwj.13929 · Cited by 9
Rohozian, Y., & Noskova, S. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-383-390 · Cited by 9
Narayan, N., Ramegowda, Y. H., Raghupathi, D. S., Chethan, S., & Gowda, S. N. (2025) · Cureus · doi:10.7759/cureus.90956 · Cited by 8
Role of Innate Immune Cells in Chronic Diabetic Wounds
Raghavan, J. V., & Jhunjhunwala, S. (2023) · Journal of the Indian Institute of Science · doi:10.1007/s41745-022-00355-4 · Cited by 8
Theocharidis, G., Sumpio, B. J., Wang, E., Mezghani, I., Giurini, J. M., Kalavros, N., Valsami, E., Vlachos, I. S., Heydarpour, M., & Veves, A. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0126 · Cited by 8
Anoop, G., Kamaraj, M., Nithya, T. G., Babu, P. R., & Babu, S. S. (2025) · Cell and Tissue Banking · doi:10.1007/s10561-025-10167-2 · Cited by 8
Campitiello, F., Mancone, M., Corte, A. D., Guerniero, R., & Canonico, S. (2018) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000531350.08738.34 · Cited by 8
Are Surrogate Markers for Diabetic Foot Osteomyelitis Remission Reliable?
Crisologo, P. A., Malone, M., Fontaine, J. L., Öz, O. K., Bhavan, K., Nichols, A., & Lavery, L. A. (2020) · Journal of the American Podiatric Medical Association · doi:10.7547/20-147 · Cited by 8
Self-citationA diabetic foot ulcer treated with hydrogel and hyperbaric oxygen therapy: a case study
de Aguiar, P. H. P., Amaral, C., Rodrigues, A., & de Souza, A. H. (2017) · Journal of Wound Care · doi:10.12968/jowc.2017.26.11.692 · Cited by 8
Davis, K. E., Killeen, A. L., Farrar, D., Raspovic, K. M., Berriman-Rozen, Z. D., Malone, M., & Lavery, L. A. (2020) · International Wound Journal · doi:10.1111/iwj.13479 · Cited by 8
Self-citationAdvancement in wound healing treatment using functional nanocarriers
Lukhey, M. S., & Shende, P. K. (2022) · International Journal of Polymeric Materials · doi:10.1080/00914037.2022.2099393 · Cited by 8
Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
Kim, P. J., Attinger, C. E., Orgill, D. P., Galiano, R. D., Steinberg, J. S., Evans, K. K., & Lavery, L. A. (2019) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000002129 · Cited by 8
Self-citationNarayan, N., Raghupathi, D. S., Ramamurthy, V., Chethan, S., & Gowda, S. N. (2025) · Cureus · doi:10.7759/cureus.96977 · Cited by 7
Chávez, J. C. P., Dobricic, M., McGrath, M., O’Connor, C., McGuire, T. K., Maughan, J., Dervan, A. G., Dixon, J. E., Kearney, C. J., Browne, S., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.02.004 · Cited by 7
Lee, Y. J., Han, H. J., & Shim, H. (2024) · Journal of Wound Care · doi:10.12968/jowc.2024.33.5.348 · Cited by 7
Lavery, L. A., Suludere, M. A., Raspovic, K., Crisologo, P. A., Johnson, M. J., & Tarricone, A. N. (2025) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346241276697 · Cited by 7
Self-citationFuture Directions in Research in Transcriptomics in the Healing of Diabetic Foot Ulcers
Sumpio, B. J., Li, Z., Wang, E., Mezghani, I., Theocharidis, G., & Veves, A. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02348-2 · Cited by 7
Browne, S., Petit, N., & Quondamatteo, F. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03849-4 · Cited by 7
Tai, T.-Y., Lin, K.-J., Chang, H.-Y., Wu, Y., Huang, C.-U., Lin, X., Tsai, F., Tsai, C.-S., Chen, Y., Wang, F., et al. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000898 · Cited by 7
Use of Therapeutic RNAs to Accelerate Wound Healing in Diabetic Rabbit Wounds
Sumpio, B. J., Dallas, A., Berger, A. G., Li, Z., Wang, E., Mezghani, I., Contreras, M., Theocharidis, G., Ilves, H., Hammond, P. T., et al. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0056 · Cited by 7
FORMATION OF MARKETING MANAGEMENT SYSTEM OF THE ENTERPRISE
Tkachenko, V. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-208-213 · Cited by 7
Caporusso, J., Motley, T. A., Lantis, J. C., Heisler, S., Hicks, A., Wu, S., & Reyzelman, A. M. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70110 · Cited by 6
Self-citationDeng, T., Li, J., Li, X., Yang, X., Tao, M., Wang, Y., Wang, X., Sun, L., Li, H., & Wu, M. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124168 · Cited by 6
Intervenciones de enfermería para mejorar la calidad de vida de las personas con pie diabético
Alpízar, C. M. C., & Valenciano, L. R. (2018) · Journal Health NPEPS · doi:10.30681/252610103127 · Cited by 6
Cellular- and Acellular-Based Therapies: Skin Substitutes and Matrices
Cahn, B. A., & Lev‐Tov, H. A. (2020) · Updates in clinical dermatology · doi:10.1007/978-3-030-28872-3_15 · Cited by 6
Armstrong, D. G., Orgill, D. P., Galiano, R. D., Glat, P. M., Carter, M. J., Hanft, J. R., Surprenant, M. S., Isaac, A. L., & Zelen, C. M. (2024) · International Wound Journal · doi:10.1111/iwj.70029 · Cited by 6
Pogorelov, Y. S., & Ivchenko, Y. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-358-366 · Cited by 6
FEATURES OF SOCIO-ECONOMIC DEVELOPMENT OF THE BALTIC STATES AND UKRAINE
Davydenko, N., & Pasichnyk, Y. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-5-97-102 · Cited by 6
Shah, A., & Taupin, P. (2022) · Case Reports in Plastic Surgery and Hand Surgery · doi:10.1080/23320885.2022.2047052 · Cited by 6
Lu, W., Hu, M. Q., Zheng, Z., Slaughter, J., Hingorani, A., & Oropallo, A. (2025) · JVS-Vascular Insights · doi:10.1016/j.jvsvi.2025.100215 · Cited by 5
Dermal Regenerative Templates in Orthopaedic Surgery
Pidgeon, T. S., Hollins, A. W., Mithani, S. K., & Klifto, C. S. (2023) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-22-01089 · Cited by 5
SPECIFICATIONS OF THE SOURCES OF SECURING INSURANCE COMPANY’S FINANCIAL STABILITY
Balytska, M. (2017) · Baltic Journal of Economic Studies · doi:10.30525/2256-0742/2017-3-1-4-10 · Cited by 5
Matrices and Dermal Substitutes for Wound Treatment
Jordan, S. W., Turin, S. Y., Zielinski, E. R., & Galiano, R. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-66990-8_13 · Cited by 5
Metadata
- Authors
- Driver, V. R., Lavery, L. A., Reyzelman, A. M., Dutra, T. G., Dove, C. R., Kotsis, S. V., Kim, H. M., & Chung, K. C.
- Affiliations
- Brown University (US)
- The University of Texas Southwestern Medical Center (US)
- University of California, San Francisco (US)
- Samuel Merritt University (US)
- Advanced Foot & Ankle Center Las Vegas Nevada
- University of Michigan (US)
- Corresponding author
- Driver, Vickie R.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2015-10-19
- Volume
- 23
- Issue
- 6
- Pages
- 891-900
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2159363192
- Semantic Scholar
- d7c51f0598a489f6edfd9a38e932c572e1097785
- Cited by
- 291
- References
- 33
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 39 · 2023: 31 · 2022: 31 · 2021: 15 · 2020: 30 · 2019: 20 · 2018: 31 · 2017: 40 · 2016: 7 · 2015: 1
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Integra LifeSciences Corporation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- diabetic foot ulcer, Integra dermal regeneration template, skin substitutes, wound healing, re-epithelialization, wound closure, diabetes mellitus, quality of life, adverse events
- MeSH terms
- Chondroitin Sulfates, Collagen, Follow-Up Studies, Humans, Middle Aged, Quality of Life, Regeneration, United States, Wound Healing, Treatment Outcome, Practice Guidelines as Topic, Diabetic Foot, Re-Epithelialization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-11-13, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-11-13 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
