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A clinical trial of Integra Template for diabetic foot ulcer treatment
Open accessAbstract
Individuals with diabetes mellitus are at an increased risk of developing a diabetic foot ulcer (DFU). This study evaluated the safety and efficacy of Integra Dermal Regeneration Template (IDRT) for the treatment of nonhealing DFUs. The Foot Ulcer New Dermal Replacement Study was a multicenter, randomized, controlled, parallel group clinical trial conducted under an Investigational Device Exemption. Thirty‐two sites enrolled and randomized 307 subjects with at least one DFU. Consented patients were entered into the 14‐day run‐in phase where they were treated with the standard of care (0.9% sodium chloride gel) plus a secondary dressing and an offloading/protective device. Patients with less than 30% reepithelialization of the study ulcer after the run‐in phase were randomized into the treatment phase. The subjects were randomized to the control treatment group (0.9% sodium chloride gel; n = 153) or the active treatment group (IDRT, n = 154). The treatment phase was 16 weeks or until confirmation of complete wound closure (100% reepithelialization of the wound surface), whichever occurred first. Following the treatment phase, all subjects were followed for 12 weeks. Complete DFU closure during the treatment phase was significantly greater with IDRT treatment (51%) than control treatment (32%; p = 0.001) at sixteen weeks. The median time to complete DFU closure was 43 days for IDRT subjects and 78 days for control subjects in wounds that healed. The rate of wound size reduction was 7.2% per week for IDRT subjects vs. 4.8% per week for control subjects ( p = 0.012). For the treatment of chronic DFUs, IDRT treatment decreased the time to complete wound closure, increased the rate of wound closure, improved components of quality of life and had less adverse events compared with the standard of care treatment. IDRT could greatly enhance the treatment of nonhealing DFUs.
Overview
CoChat Summary
TL;DR
In the FOUNDER multicenter randomized trial, Integra Dermal Regeneration Template (IDRT) significantly increased complete closure of chronic diabetic foot ulcers compared with standard of care. IDRT also reduced time to closure and improved some quality-of-life measures, with fewer severe adverse events.
Key findings
- Complete DFU closure during the 16-week treatment phase was 51% (79/154) with IDRT vs 32% (49/153) with control (p = 0.001); by blinded computerized planimetry, closure was 50% vs 31% (p = 0.001).
- Median time to complete closure among healed wounds was 43 days for IDRT vs 78 days for control; wound size reduction was 7.2% per week vs 4.8% per week (p = 0.012).
- At 12 weeks, complete closure was 45% (70/154) with IDRT vs 20% (31/153) with control (p < 0.001), with an odds ratio of 3.3 (95% CI 2.0, 5.4).
- Severe adverse events occurred in 15.6% of IDRT subjects vs 26.8% of control subjects (p = 0.016); quality-of-life improvements were significant for Physical Functioning (p = 0.047) and Bodily Pain (p = 0.033).
Methods
- Multicenter, randomized, controlled, parallel-group trial under an Investigational Device Exemption at 32 sites; 307 subjects with nonhealing DFUs were randomized 1:1 to IDRT (n = 154) or control saline gel standard of care (n = 153) after a 14-day run-in in which only ulcers with less than 30% reepithelialization were randomized.
- Treatment phase lasted up to 16 weeks or until confirmed complete wound closure, followed by a 12-week follow-up; the primary endpoint was investigator-assessed complete closure during the treatment phase, with blinded central computerized planimetry as a secondary assessment.
- Efficacy analyses used the intent-to-treat cohort; primary outcome used logistic regression adjusted for baseline ulcer size strata, with secondary outcomes analyzed by Cox regression, linear mixed-effects models, and closed testing to maintain type I error at 0.05.
Limitations
- The paper states that the study was not double-blinded, a limitation it notes applies to this and other DFU studies involving cellular and/or tissue-based products; it reports that this bias was addressed by third-party blinded computerized planimetry.
- The paper states that strict inclusion/exclusion criteria could affect generalizability, though it argues this was minimized by enrolling from 32 academic and private practice sites across the United States.
- Evident from the text: the study was sponsored and funded by Integra LifeSciences Corporation, and multiple authors report grants, personal fees, or nonfinancial support from Integra, which is not framed by the authors as a limitation.
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0 Valid · 0 Not valid · 19 Not checked · 53 Own results and interpretations
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cell-based products also need multiple reapplications in treating a DFU whereas this study demonstrated that reapplications of IDRT are generally not necessary.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > DISCUSSION
boosted- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Complete DFU closure during the treatment phase was significantly greater with IDRT treatment (51%) than control treatment (32%; p 5 0.001) at sixteen weeks.”
- Also stated in: § Study subjects · plain
“Complete closure of the study ulcer during the treatment phase (16 weeks), as defined by the investigator, was significantly greater in the active group (51%; 79/154) in comparison to the control group (32%; 49/153, p 5 0.001).”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plainstates a cause- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Study subjects · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The median time to complete DFU closure was 43 days for IDRT subjects and 78 days for control subjects in wounds that healed.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The majority of AEs in both groups were mild.”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Study subjects
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The rate of wound size reduction was 7.2% per week for IDRT subjects vs. 4.8% per week for control subjects (p 5 0.012).”
§ A clinical trial of Integra Template for diabetic foot ulcer treatment > Abstract
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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“Although the final follow-up wound area was similar between two treatment groups, the percentage area reduction (PAR) was demonstrated to be significantly increased in several studies [23, 26, 27, 31, 34].”
From Effectiveness and safety of dermal matrix used for diabetic foot ulcer: a systematic review and meta-analysis of randomized controlled trials (2024) · cites this paper as [23]
Citations
Cites
Incidence, outcomes, and cost of foot ulcers in patients with diabetes.
Ramsey, S. D., Newton, K. M., Blough, D. K., McCulloch, D. K., Sandhu, N., Reiber, G. E., & Wagner, E. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.3.382 · Cited by 1,064
Design of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140108 · Cited by 1,044
Design of an artificial skin. I. Basic design principles
Yannas, I. V., & Burke, J. F. (1980) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820140314 · Cited by 889
Risk Factors for Foot Infections in Individuals With Diabetes
Lavery, L. A., Armstrong, D. G., Wunderlich, R. P., Mohler, M. J., Wendel, C. S., & Lipsky, B. A. (2006) · Diabetes Care · doi:10.2337/dc05-2425 · Cited by 787
Self-citationWieman, T. J., Smiell, J. M., & Su, Y. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.822 · Cited by 683
Veves, A., Falanga, V., Armstrong, D. G., Sabolinski, M. L., & Study, T. A. D. F. U. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.290 · Cited by 643
Burden of Diabetic Foot Ulcers for Medicare and Private Insurers
Rice, J. B., Desai, U., Cummings, A. K. G., Birnbaum, H. G., Skornicki, M., & Parsons, N. B. (2014) · Diabetes Care · doi:10.2337/dc13-2176 · Cited by 624
The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot Ulcers
Marston, W. A., Hanft, J., Norwood, P., Pollak, R., & for the Dermagraft Diabetic Foot Ulcer Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1701 · Cited by 613
Steed, D. L., & the Diabetic Ulcer Study Group * (1995) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(95)70245-8 · Cited by 610
Lower-Extremity Amputation in People With Diabetes: Epidemiology and Prevention
Bild, D. E., Selby, J. V., Sinnock, P., Browner, W. S., Braveman, P., & Showstack, J. A. (1989) · Diabetes Care · doi:10.2337/diacare.12.1.24 · Cited by 517
Research works printed but not linked: 3
- Boulton A, 2005, Diabetic foot and ulceration: epidemiology and pathophysiology
- Gibson D, 2009, MMPs made easy, Wound Int, 1, 1
- Gethin G, 2007, Wound measurement: the contribution to practice, EWMA J., 7, 26
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Topical Wound Care Treatment and Indications for Their Use
Hargis, A., Bermudez, N. M., Yaghi, M., & Kirsner, R. S. (2024) · Contemporary diabetes · doi:10.1007/978-3-031-55715-6_22
Regeneration of the Skin and Peripheral Nerves in the Adult
Yang, A. Z., Lee, D., Dennis, D., & Lin, S. J. (2024) · Contemporary diabetes · doi:10.1007/978-3-031-55715-6_8
Use of Dermal Substitute Matrices for Coverage of Exposed Limb Vascular Repairs: A Literature Review
Makkawi, K. W., Beaineh, P. T., Habr, N. T., & Ibrahim, A. (2024) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000005855
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Kardani, S., Bhatt, M., Parmar, G. R., Shah, N., Gohil, D., Aundhia, C. J., & Maheshwari, R. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/44242
Frykberg, R. G., & Speight, J. H. (2025) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2025.06.003
Sui, L., Xie, Q., Jiang, H.-T., & Li, X.-D. (2024) · Figshare · doi:10.6084/m9.figshare.25248776
Microalga-based photosynthetic biomaterials for medical applications
Vargas-Torres, V., Becerra, D., Borić, M. P., & Egaña, J. T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34082-6.00034-9
Modélisation du pied diabétique : Etude des ADSCs et de leur sécrétome
Lemeunier, I. (2023) · theses.fr (ABES) · doi:10.70675/d1be1055zd59fz48ebza1a2z873bfb0d0dc0
Nezafati, N., Tahmasebi, M., Hesaraki, S., Taghizadeh, E., & Keshtkari, S. (2026) · Journal of Translational Regenerative Medicine · doi:10.32598/jtrm.1.1017
Manjesh, K. A., Dutt, A., Nelluri, N., Kota, S. R., Abuji, K., Narra, A. R., Mudigonda, N., Dheeraj, D. V. S., & Agarwal, E. (2026) · Cureus · doi:10.7759/cureus.111871
Differentiated application of collagen dressings in patients with diabetic foot syndrome
Lutsenko, Y. G., Karabak, I. S., & Shirshov, I. V. (2026) · Ambulatornaya khirurgiya = Ambulatory Surgery (Russia) · doi:10.21518/akh2026-026
Chau, H. Y., Chen, M., Hsia, K., & Lin, C. (2026) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2026.102135
Collagen-based dressings for diabetic foot ulcers: A systematic review.
Rahimi, S., Hosseingholizade, M., Hashemi‐Madani, N., Emami, Z., Khamseh, M. E., & Sharifi, N. (2026) · PubMed Central · doi:10.22088/cjim.17.2.278
Multimodal Bioactive Approaches in Smart Dressings for Diabetic Foot Ulcers
Zhang, J., Qin, W., Wang, X., Yue, W., Yan, J., Zong, J., & Xu, G. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s625602
Batool, F., Munawwar, F., Shaukat, H., Janjua, A. A., Niazi, U., & Changazi, S. H. (2026) · Cureus · doi:10.7759/cureus.114872
Multi-layer wound dressings for managing diabetic foot ulcers
Barkhordari, S., Alnaimat, F., Naqvi, M., Moghaddam, A., & Khonakdar, H. A. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100941
Chávez, J. C. P., Erugo, A., Dobricic, M., Maini, A. A., Maughan, J., Dixon, J. E., Kearney, C. J., Browne, S., & O’Brien, F. J. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7390604
Collagen-based medical devices: technological basis and clinical studies
Voloshin, S., Giliazova, A., Rudakov, E., Istranova, E. V., Timashev, P. S., & Antoshin, A. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1971640
Metadata
- Authors
- Driver, V. R., Lavery, L. A., Reyzelman, A. M., Dutra, T. G., Dove, C. R., Kotsis, S. V., Kim, H. M., & Chung, K. C.
- Affiliations
- Brown University (US)
- The University of Texas Southwestern Medical Center (US)
- University of California, San Francisco (US)
- Samuel Merritt University (US)
- Advanced Foot & Ankle Center Las Vegas Nevada
- University of Michigan (US)
- Corresponding author
- Driver, Vickie R.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2015-10-19
- Volume
- 23
- Issue
- 6
- Pages
- 891-900
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2159363192
- Semantic Scholar
- d7c51f0598a489f6edfd9a38e932c572e1097785
- Cited by
- 291
- References
- 33
- Citations by year
- 2026: 21 · 2025: 24 · 2024: 39 · 2023: 31 · 2022: 31 · 2021: 15 · 2020: 30 · 2019: 20 · 2018: 31 · 2017: 40 · 2016: 7 · 2015: 1
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Integra LifeSciences Corporation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- diabetic foot ulcer, Integra dermal regeneration template, skin substitutes, wound healing, re-epithelialization, wound closure, diabetes mellitus, quality of life, adverse events
- MeSH terms
- Chondroitin Sulfates, Collagen, Follow-Up Studies, Humans, Middle Aged, Quality of Life, Regeneration, United States, Wound Healing, Treatment Outcome, Practice Guidelines as Topic, Diabetic Foot, Re-Epithelialization
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