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Cited by 8Cardiovascular and exercise physiologyPhysical Activity and HealthSports Performance and Training

The effects of habitual resistance exercise training on cerebrovascular responses to lower body dynamic resistance exercise: a cross-sectional study

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Korad, Stephanie, Mündel, Toby, Perry, Blake G.·2024·Experimental Physiology
DOI 10.1113/ep091707PMC PMC11363110
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Abstract

Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure with simultaneous fluctuations in middle cerebral artery blood velocity (MCAv). Some evidence indicates that RE may alter cerebrovascular function. This study aimed to examine the effects of habitual RE training on the within‐RE cerebrovascular responses. RE‐trained (n = 15, Female = 4) and healthy untrained individuals (n = 15, Female = 12) completed four sets of 10 paced repetitions (15 repetitions per minute) of unilateral leg extension exercise at 60% of predicted 1 repetition maximum. Beat‐to‐beat blood pressure, MCAv and end‐tidal carbon dioxide were measured throughout. Zenith, nadir and zenith‐to‐nadir difference in mean arterial blood pressure (MAP) and mean MCAv (MCAv mean) for each repetition were averaged across each set. Two‐way ANOVA was used to analyse dependent variables (training × sets), Bonferroni corrected t‐tests were used for post hoc pairwise comparisons. Group age (26 ± 7 trained vs. 25 ± 6 years untrained, P = 0.683) and weight (78 ± 15 vs. 71 ± 15 kg, P = 0.683) were not different. During exercise average MAP was greater for the RE‐trained group in sets 2, 3 and 4 (e.g., set 4: 101 ± 11 vs. 92 ± 7 mmHg for RE trained and untrained, respectively, post hoc tests all P = < 0.012). Zenith MAP and zenith‐to‐nadir MAP difference demonstrated a training effect (P < 0.039). Average MCAv mean and MCAv mean zenith‐to‐nadir difference was not different between groups (interaction effect P = 0.166 and P = 0.459, respectively). Despite RE‐trained individuals demonstrating greater fluctuations in MAP during RE compared to untrained, there were no differences in MCAv mean. Regular RE may lead to vascular adaptations that stabilise MCAv during RE.

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  • Well-trained individuals demonstrate improved cerebral blood flow velocity and regulation, allowing them to maintain brain perfusion even with fluctuations in blood pressure under physical exertion or heat stress, a mechanism that is less efficient in untrained individuals.

    “For instance, well-trained individuals demonstrate improved cerebral blood flow velocity25 and regulation,26 allowing them to maintain brain perfusion even with fluctuations in blood pressure under physical exertion or heat stress, a mechanism that is less efficient in untrained individuals.”

    From Influence of habitual physical activity on cognitive performance of healthy young adults after passive heat exposure (2026) · cites this paper as [26]

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Cited by

Sorted by citations

Authors
Korad, S., Mündel, T., & Perry, B. G.
Affiliations
  • Massey University (NZ)
  • Brock University (CA)
Corresponding author
Korad, Stephanie
ORCID
Venue
Experimental Physiology
Publisher
Wiley
Published
2024-06-18
Volume
109
Issue
9
Pages
1478-1491
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
DOI
10.1113/ep091707
PMC
PMC11363110
OpenAlex
W4399773416
Cited by
8
References
2
Citations by year
2026: 1 · 2025: 6 · 2024: 1
FWCI
3.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Experimental Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • University of Otago
  • Massey University
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
resistance training, cerebrovascular function, middle cerebral artery blood flow velocity, blood pressure fluctuation, leg extension, end-tidal carbon dioxide, trained vs untrained subjects, vascular adaptation
MeSH terms
Adult, Blood Flow Velocity, Blood Pressure, Cerebrovascular Circulation, Cross-Sectional Studies, Female, Humans, Male, Exercise, Middle Cerebral Artery, Resistance Training, Young Adult

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