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THE EFFECTS OF BOTULINUM TOXIN ON THE PATTERN OF INNERVATION OF SKELETAL MUSCLE IN THE MOUSE
Open accessAbstract
Sublethal quantities of botulinum toxin were injected into the gastrocnemius and hamstring muscles of one leg in mice. Local paralysis and atrophy occurred and persisted for a few weeks. Histological examination showed no degeneration of nerve fibres or of motor nerve endings. Silver impregnations showed that during the period of muscle paralysis there was growth of motor nerve fibres from the terminal arborizations. Nerve fibre overgrowth was accompanied by elongation and abnormal configuration of sites of cholinesterase activity. As muscle function recovered the nerve fibre overgrowth receded and well‐formed though still abnormally shaped subneural apparatuses were seen. Nine months after the injection of the toxin, the pattern of innervation of the muscle was still abnormal. The growth of motor nerve fibres after the injection of botulinum toxin appears to be a response to the failure of neuromuscular transmission and is not analogous to regeneration of nerve fibres after trauma.
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Cited by
The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury
Lieberman, A. R. (1971) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60183-x · Cited by 1,115
Sprouting and regression of neuromuscular synapses in partially denervated mammalian muscles.
Brown, M. C., & Ironton, R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012307 · Cited by 318
Effects of aging on nerve sprouting and regeneration
Pestronk, A., Drachman, D. B., & Griffin, J. W. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90006-0 · Cited by 259
Zhao, H., & Nonet, M. L. (2000) · Development · doi:10.1242/dev.127.6.1253 · Cited by 57
Metadata
- Authors
- Duchen, L. W., & Strich, S. J.
- Venue
- Quarterly Journal of Experimental Physiology and Cognate Medical Sciences
- Publisher
- Wiley
- Published
- 1968-01-22
- Volume
- 53
- Issue
- 1
- Pages
- 84-89
- ISSN
- 0033-5541 (ISSN-L)
- OpenAlex
- W2068624139
- Cited by
- 279
- References
- 0
- FWCI
- 18.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: THE EFFECTS OF BOTULINUM TOXIN ON THE PATTERN OF INNERVATION OF SKELETAL MUSCLE IN THE MOUSE. https://app.cochat.ai/papers/10.1113/expphysiol.1968.sp001948
- The paper
- Duchen, L. W., & Strich, S. J. (1968). THE EFFECTS OF BOTULINUM TOXIN ON THE PATTERN OF INNERVATION OF SKELETAL MUSCLE IN THE MOUSE. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences. https://doi.org/10.1113/expphysiol.1968.sp001948
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
