THE EFFECT OF THE NUTRITIONAL STATE ON UTERINE PROSTAGLANDIN F METABOLITE CONCENTRATIONS IN THE PREGNANT EWE DURING LATE GESTATION

Fowden, Abigail L.; Silver, Marian

doi:10.1113/expphysiol.1983.sp002729

Cited by 47Reproductive Physiology in LivestockRuminant Nutrition and Digestive PhysiologyBirth, Development, and Health

THE EFFECT OF THE NUTRITIONAL STATE ON UTERINE PROSTAGLANDIN F METABOLITE CONCENTRATIONS IN THE PREGNANT EWE DURING LATE GESTATION

Fowden, Abigail L., Silver, Marian·1983·Quarterly Journal of Experimental Physiology

DOI 10.1113/expphysiol.1983.sp002729

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Abstract

The effects of nutritional state and nutrient availability on arterial and uterine venous concentrations of 13, 14 dihydro‐15‐ketoprostaglandin F 2 α (PGFM) have been investigated in chronically catheterized pregnant ewes during late gestation (120‐144 d; term = 147 d). Before the daily feed of concentrates was given, a significant positive venous‐arterial (V-A) difference in plasma PGFM concentration was observed across the uterus, irrespective of the number of fetuses or the gestational age (mean value at 135 ± 2 d: 0·42 ± 0·06 ng/ml, n = 13, P 〈 0·01). However, by 3‐5 h after feeding, no significant difference in PGFM concentration could be detected across the uterus. Withdrawal of food but not water for 48 h increased the plasma PGFM levels and widened the V‐A difference in PGFM concentration across the uterus at all gestational ages studied but had the greatest effect in late gestation (〉 137 d). These changes in plasma PGFM were accompanied by a fall in glucose and a rise in free fatty acid (FFA) concentration in the arterial plasma. When these metabolite changes were reversed at the end of the fast either by refeeding or by glucose infusion, there was a rapid fall in PGFM concentration and a narrowing of the uterine V‐A difference. Induction of hypoglycaemia by infusion of insulin also led to a widening of the V‐A difference in PGFM concentration across the uterus. There was a significant inverse correlation between the arterial plasma glucose level and the V‐A difference in PGFM concentration across the uterus during feeding, fasting and insulin infusion. The V‐A difference in PGFM concentration was also positively correlated with the arterial plasma FFA level under these conditions. When arterial plasma concentrations of PGFM rose above 3 ng/ml, during fasting or insulin induced hypoglycaemia, the ewes lambed within 12‐24 h of restoring the metabolite concentrations. These observations indicate that the output of PGFM by the uterus is controlled in some way by the availability of nutrients and emphasize the importance of a regular food intake during late gestation in the ewes.

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There is increased utero-placental production of prostaglandins E and F2α when maternal glucose levels fall due to fasting or insulin infusion in the ewe.
“In particular, there is increased utero-placental production of prostaglandins E and F2α when maternal glucose levels fall due to fasting or insulin infusion in the ewe (192,197).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [197]

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Authors: Fowden, A. L., & Silver, M.
Affiliations: University of Cambridge (GB)
ORCID: Fowden, Abigail L.
Venue: Quarterly Journal of Experimental Physiology
Publisher: Wiley
Published: 1983-07-16
Volume: 68
Issue: 3
Pages: 337-349
ISSN: 0144-8757 (ISSN-L)
DOI: 10.1113/expphysiol.1983.sp002729
OpenAlex: W2002565283
Cited by: 47
References: 0
Citations by year: 2026: 1 · 2024: 1 · 2021: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Quarterly Journal of Experimental Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: late pregnancy, pregnant ewes, nutritional status, fasting, hypoglycemia, insulin, plasma glucose, free fatty acids, nutrient availability
MeSH terms: Animals, Fatty Acids, Nonesterified, Female, Insulin, Nutritional Physiological Phenomena, Pregnancy, Pregnancy, Animal, Progesterone, Prostaglandins, Prostaglandins F, Sheep, Uterus, Dinoprost

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THE EFFECT OF THE NUTRITIONAL STATE ON UTERINE PROSTAGLANDIN F METABOLITE CONCENTRATIONS IN THE PREGNANT EWE DURING LATE GESTATION

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