Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury
Abstract
Hydrogen sulfide (H(2)S) has been known as a highly toxic gas for several centuries. There have been considerable advances made in the H(2)S field regarding its physiological role; however, there is much more work that needs to be done. The biosynthesis of H(2)S has been attributed to three endogenous enzymes: cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL or CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). These enzymes require further investigation to more fully elucidate the cellular expression profile, regulation and precise role of these critical enzymes in the production of H(2)S. In recent years, H(2)S has been demonstrated to have cytoprotective effects in multiple organ systems. In particular, it has been demonstrated that the administration of H(2)S either prior to ischaemia or at reperfusion significantly ameliorates myocardial and hepatic ischaemia-reperfusion injury. Therefore, this review focuses on the cardioprotective and hepatoprotective role of H(2)S. In addition, the review provides a summary of several known molecular targets of H(2)S protection.
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Hydrogen sulfide can scavenge ROS and act as a defense against ischemia-reperfusion injury, affect redox balance, and inhibit enzymes including NADPH oxidase and nitric oxide synthase.
“In addition, it can scavenge ROS and so act as a defense against ischemia-reperfusion injury (310), affect the redox balance, and also inhibit a number of related enzymes, including NADPH oxidase and nitric oxide synthase.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [310]
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- Authors
- King, A. L., & Lefer, D. J.
- Affiliations
- Emory University (US)
- Venue
- Experimental Physiology
- Publisher
- Wiley
- Published
- 2011-07-07
- Volume
- 96
- Issue
- 9
- Pages
- 840-846
- ISSN
- 0958-0670 (ISSN-L)
- OpenAlex
- W2117669927
- Cited by
- 78
- References
- 41
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 14 · 2014: 6 · 2013: 9 · 2012: 5
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Surgery › Hydrogen's biological and therapeutic effects
- Keywords
- hydrogen sulfide, ischemia-reperfusion injury, cytoprotection, cardioprotection, hepatoprotection, cystathionine beta-synthase, cystathionine gamma-lyase, 3-mercaptopyruvate sulfurtransferase, H2S biosynthesis
- MeSH terms
- Cystathionine beta-Synthase, Cystathionine gamma-Lyase, Humans, Hydrogen Sulfide, Liver, Mitochondria, Protein Processing, Post-Translational, Sulfurtransferases, Potassium Channels, Signal Transduction, Reperfusion Injury, Myocardial Reperfusion Injury, Cytoprotection
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