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Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions
Open accessAbstract
1. Frog cutaneous pectoris nerve‐muscle preparations were incubated with collagenase and protease and examined with electrophysiological and electron microscopic techniques. 2. The physiological properties and intracellular ultrastructural appearance of individual muscle and nerve cells were not affected by the enzyme treatment. However, neuromuscular transmission and the morphology of the nerve‐muscle junction were altered. 3. Collagenase produced an irreversible loss of activity of end‐plate cholinesterase and a partial loss of stainable ‘synaptic cleft material’. 4. Protease produced these changes and, in addition, the entire basement membrane was digested, which led to ‘synaptic disjunction’ of nerve terminals and muscle end‐plates.
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Citations
Cited by
Single-channel currents recorded from membrane of denervated frog muscle fibres
NEHER, E., & SAKMANN, B. (1976) · Nature · doi:10.1038/260799a0 · Cited by 2,570
Self-citationLocal anaesthetics transiently block currents through single acetylcholine‐receptor channels.
Neher, E., & Steinbach, J. H. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012267 · Cited by 844
Cholinesterase is associated with the basal lamina at the neuromuscular junction
MCMAHAN, U. J., SANES, J. R., & MARSHALL, L. M. (1978) · Nature · doi:10.1038/271172a0 · Cited by 400
Bartol, T. M., Land, B. R., Salpeter, E. E., & Salpeter, M. M. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82344-x · Cited by 217
Metadata
- Authors
- Betz, W., & Sakmann, B.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1973-05
- Volume
- 230
- Issue
- 3
- Pages
- 673-688
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2097968226
- Cited by
- 210
- References
- 0
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
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