Wave‐length dependencies of light scattering in normal and cold swollen rabbit corneas and their structural implications*
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1. The studies described herein involve the use of light scattering measurements to characterize the ultrastructural arrangement of the constituent collagen fibrils in rabbit corneal stromas. 2. Theoretical light scattering techniques for calculating the scattering to be expected from the structures revealed by electron micrographs are discussed, and comparison with the experimental light scattering tests the validity of these structures. 3. The wave‐length dependence of light transmission and of angular light scattering from normal corneas is in agreement with the short range ordering of collagen fibrils depicted in electron micrographs. 4. The transmission measurements on oedematous rabbit corneas indicate that transmission decreases linearly with the ratio of thickness to normal thickness. 5. The wave‐length dependence of transmission through cold swollen corneas indicates that the increased scattering is caused by large inhomogeneities in the ultrastructure. Electron micrographs do, indeed, reveal the presence of such inhomogeneities in the form of large regions completely devoid of fibrils.
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The two most commonly used techniques to measure corneal transparency ex vivo are tungsten light-based or laser-based bench-top optical systems, or spectrophotometry.
“The two most commonly used techniques to measure corneal transparency ex vivo are tungsten light-based or laser-based bench-top optical systems (Farrell et al., 1973, Christens-Barry et al., 1996, Parekh et al., 2014), or spectrophotometry (Cejka et al., 2010, Doutch et al., 2008).”
From Corneal structure and transparency (2015) · cites this paper as Farrell et al., 1973
The λ−3 dependence found in rabbit corneas indicates that the fibril arrangement seen in micrographs, which has short range order, is a very good representation of the fibril arrangement present in corneal lamellae in vivo.
“we can take it as an indication that the fibril arrangement seen in micrographs, which has short range order (Fig. 12b, inset) is a very good representation of the fibril arrangement present in the corneal lamellae in vivo (Farrell et al., 1973).”
From Corneal structure and transparency (2015) · cites this paper as Farrell et al., 1973
Experimental measurements from rabbit corneas in the visible spectrum have found a λ−3 dependence for the transmission of the scattered light.
“Since experimental measurements from rabbit corneas in the visible spectrum have found a λ−3 dependence for the transmission of the scattered light (Farrell et al., 1973)”
From Corneal structure and transparency (2015) · cites this paper as Farrell et al., 1973
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
- Authors
- Farrell, R. A., McCally, R. L., & Tatham, P. E. R.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1973-09
- Volume
- 233
- Issue
- 3
- Pages
- 589-612
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1350594
- OpenAlex
- W2070981006
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
- Keywords
- corneal light scattering, wavelength dependence, corneal stroma, collagen fibrils, corneal edema, corneal ultrastructure, optical transmittance, angular light scattering, cornea
- MeSH terms
- Animals, Cold Temperature, Collagen, Cornea, Edema, Light, Mathematics, Microscopy, Electron, Rabbits, Scattering, Radiation
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