Review lecture. The blood‐brain barrier.

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629 · see citing works

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,691 · see citing works

Facilitated transfer of glucose from blood into brain tissue.

Crone, C. G. (1965) · The Journal of Physiology · doi:10.1113/jphysiol.1965.sp007748 · Cited by 443 · see citing works

THE CONCENTRATIONS OF FREE AMINO ACIDS AND OTHER ELECTROLYTES IN CEREBROSPINAL FLUID, IN VIVO DIALYSATE OF BRAIN, AND BLOOD PLASMA OF THE DOG*

Bito, L. Z., Davson, H., Levin, Е., Murray, M., & Snider, N. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb04265.x · Cited by 352 · see citing works

THE MECHANISM OF DRAINAGE OF THE CEREBROSPINAL FLUID

Davson, H., Domer, F. R., & Hollingsworth, J. R. (1973) · Brain · doi:10.1093/brain/96.2.329 · Cited by 313 · see citing works

Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood

Pappenheimer, J. R., Heisey, S. R., & Jordan, E. F. (1961) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1961.200.1.1 · Cited by 297 · see citing works

The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. II. Parenchymal distribution

Brightman, M. (1965) · American Journal of Anatomy · doi:10.1002/aja.1001170204 · Cited by 252 · see citing works

THE MECHANISM OF DRAINAGE OF THE CEREBROSPINAL FLUID

Davson, H., HOLLINGSWORTH, G., & Segal, M. B. (1970) · Brain · doi:10.1093/brain/93.4.665 · Cited by 247 · see citing works

Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system.

Diamond, I., & Schmid, R. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105383 · Cited by 241 · see citing works

Penetration of 14C-inulin and 14C-sucrose into brain, cerebrospinal fluid, and skeletal muscle of developing rats

Ferguson, R., & Woodbury, D. M. (1969) · Experimental Brain Research · doi:10.1007/bf00239028 · Cited by 187 · see citing works

A comparative study of the aqueous humour and cerebrospinal fluid in the rabbit

Davson, H. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005341 · Cited by 183 · see citing works

Stereospecificity of blood-brain barrier permeability to amino acids

Oldendorf, W. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.4.967 · Cited by 162 · see citing works

The development of a blood‐brain barrier mechanism in foetal sheep

Evans, C. A. N., Reynolds, J. M., Reynolds, M. L., Saunders, N. R., & Segal, M. B. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010530 · Cited by 158 · see citing works

Cerebral glucose transport and oxygen consumption in sheep and rabbits

Pappenheimer, J. R., & Setchell, B. P. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010322 · Cited by 138 · see citing works

Stability of the potassium content of cerebrospinal fluid and brain

Bradbury, M. W. B., & Cr, K. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.213.2.519 · Cited by 131 · see citing works

Efflux mechanism contributing to the stability of the potassium concentration in cerebrospinal fluid

Bradbury, M. W. B., & Štulcová, B. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009128 · Cited by 130 · see citing works

The transport of urea, creatinine and certain monosaccharides between blood and fluid perfusing the cerebral ventricular system of rabbits

Bradbury, M. W. B., & Davson, H. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007323 · Cited by 126 · see citing works

Blood-brain transfer of glucose and other molecules measured by rapid indicator dilution

Yudilevich, D., & Rose, N. D. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.3.841 · Cited by 123 · see citing works

Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid

Tripathi, B. J., & Tripathi, R. C. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010563 · Cited by 116 · see citing works

The influx of amino acids into the brain of the rat in vivo : the essential compared with some non-essential amino acids

Baños, G., Daniel, P. M., Moorhouse, S. R., & PRATT, O. E. (1973) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1973.0004 · Cited by 104 · see citing works

Intraocular fluid dynamics. III. The site and mechanism of prostaglandin transfer across the blood intraocular fluid barriers

Bito, L. Z., & Salvador, E. V. (1972) · Experimental Eye Research · doi:10.1016/0014-4835(72)90008-5 · Cited by 103 · see citing works

Factors affecting the distribution of iodide and bromide in the central nervous system*

Bito, L. Z., Bradbury, M. W. B., & Davson, H. (1966) · The Journal of Physiology · doi:10.1113/jphysiol.1966.sp007989 · Cited by 87 · see citing works

FREE AMINO ACID LEVELS IN THE CEREBROSPINAL FLUID OF NORMAL HUMANS AND THEIR VARIATION IN CASES OF EPILEPSY AND SPIELMEYER‐VOGT‐BATTEN DISEASE

Plum, C. M. (1974) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1974.tb06064.x · Cited by 86 · see citing works

Functional Ultrastructure of the Arachnoid Villus

Alksne, J. F., & Lovings, E. T. (1972) · Archives of Neurology · doi:10.1001/archneur.1972.00490170003002 · Cited by 82 · see citing works

Relation of potassium concentration in choroidplexus fluid to that in plasma.

Ames, A., Higashi, K., & Nesbett, F. B. (1965) · The Journal of Physiology · doi:10.1113/jphysiol.1965.sp007779 · Cited by 74 · see citing works

Transport as Control Mechanism of Cerebral Metabolxite Levels

Lajtha, Á. (1968) · Progress in brain research · doi:10.1016/s0079-6123(08)64157-6 · Cited by 71 · see citing works

The permeation of several materials into the fluids of the rabbit's brain

Davson, H., & Welch, K. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009621 · Cited by 63 · see citing works

Transport of potassium at the blood—brain barrier

Bradbury, M. W. B., Segal, M. B., & Wilson, J. P. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009771 · Cited by 61 · see citing works

The requirements of the brain for some amino acids.

Baños, G., Daniel, P. M., Moorhouse, S. R., & PRATT, O. E. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp010903 · Cited by 57 · see citing works

Active transport of 131I across the blood—brain barrier

Davson, H., & Hollingsworth, J. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010310 · Cited by 51 · see citing works

A Comparison of the Transport Systems for Amino Acids in Brain, Intestine, Kidney and Tumour

Neame, K. D. (1968) · Progress in brain research · doi:10.1016/s0079-6123(08)64156-4 · Cited by 42 · see citing works

LEUCINE TRANSPORT FROM THE VENTRICLES AND THE CRANIAL SUBARACHNOID SPACE IN THE CAT1

Lorenzo, A. V., & Snodgrass, S. R. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01454.x · Cited by 39 · see citing works

Iodide transfer at four cerebrospinal fluid sites in the dog: Evidence for spinal iodide carrier transport

Coben, L. A., & Smith, K. R. (1969) · Experimental Neurology · doi:10.1016/0014-4886(69)90035-1 · Cited by 39 · see citing works

The Choroid Plexus as a Glucose Barrier

Csáky, T. Z., & Rigor, B. M. (1968) · Progress in brain research · doi:10.1016/s0079-6123(08)64153-9 · Cited by 31 · see citing works

The iodide space in rabbit brain

Ahmed, N., & Harreveld, A. V. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008896 · Cited by 26 · see citing works

The Influence of Glucose and Insulin Upon the Potassium Concentration of Serum and Cerebrospinal Fluid

Bekaert, J., & Demeester, G. (1951) · Archives Internationales de Physiologie · doi:10.3109/13813455109145012 · Cited by 23 · see citing works

Proceedings: Carrier-mediated removal of prostaglandins from cerebrospinal fluid.

Bito, L. Z., & Davson, H. (1974) · PubMed · Cited by 16 · see citing works

Saturable, “Carrier-mediated”, absorption of prostaglandin F2α from the in vivo rabbit vagina and its inhibition by prostaglandin F2β

Bito, L. Z., & Spellane, P. J. (1974) · Prostaglandins · doi:10.1016/s0090-6980(74)80100-0 · Cited by 16 · see citing works

The Influence of Dinitro-Alpha-Naphtol upon the Potassium Concentration of Serum and Cerebrospinal Fluid

Bekaert, J., & Demeester, G. (1952) · Archives Internationales de Physiologie · doi:10.3109/13813455209145055 · Cited by 6 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Fluid transport in the brain

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 622 · see citing works

CSF, blood-brain barrier, and brain drug delivery

Pardridge, W. M. (2016) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1171315 · Cited by 508 · see citing works

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

Betz, A. L., Firth, J. A., & Goldstein, G. W. (1980) · Brain Research · doi:10.1016/0006-8993(80)91004-5 · Cited by 400 · see citing works

Focused ultrasound-mediated drug delivery through the blood–brain barrier

Burgess, A., Shah, K., Hough, O., & Hynynen, K. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1028369 · Cited by 325 · see citing works

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

Rodríguez, E. M., Blázquez, J. L., & Guerra, M. (2010) · Peptides · doi:10.1016/j.peptides.2010.01.003 · Cited by 308 · see citing works

Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema

Wahl, M., Unterberg, A. W., Baethmann, A. J., & Schilling, L. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.109 · Cited by 293 · see citing works

Extracellular K+ accumulation in the central nervous system

Syková, E. (1983) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(83)90006-8 · Cited by 283 · see citing works

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

Saunders, N. R., Dreifuss, J.-J., Dzięgielewska, K. M., Johansson, P. A., Habgood, M. D., MøllgÃ¥rd, K., & Bauer, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00404 · Cited by 261 · see citing works

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219 · see citing works

Methods for quantifying the transport of drugs across brain barrier systems

Fenstermacher, J. D., Blasberg, R. G., & Patlak, C. S. (1981) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(81)90062-0 · Cited by 214 · see citing works

The cerebrospinal fluid and barriers – anatomic and physiologic considerations

Tumani, H., Huss, A. M., & Bachhuber, F. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804279-3.00002-2 · Cited by 210 · see citing works

Permeability and vascularity of the developing brain: Cerebellum vs cerebral cortex

Johanson, C. E. (1980) · Brain Research · doi:10.1016/0006-8993(80)91155-5 · Cited by 191 · see citing works

The blood-brain barrier. Transport across the cerebral endothelium.

Bradbury, M. W. B. (1985) · Circulation Research · doi:10.1161/01.res.57.2.213 · Cited by 189 · see citing works

Blood–Brain Barrier Efflux Transport

Golden, P. L., & Pollack, G. M. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10424 · Cited by 174 · see citing works

Vitamin Homeostasis in the Central Nervous System

Bleich, H. L., Boro, E. S., & Spector, R. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706162962409 · Cited by 171 · see citing works

Ependym und Circumventriculäre Organe

Leonhardt, V. H. (1980) · Handbuch der mikroskopischen Anatomie des Menschen · doi:10.1007/978-3-642-81358-0_3 · Cited by 162 · see citing works

Problems of delivery of drugs to the brain

Bodor, N. S., & Brewster, M. E. (1982) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(82)90073-0 · Cited by 158 · see citing works

The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain

Joo, F. (1985) · Neurochemistry International · doi:10.1016/0197-0186(85)90002-6 · Cited by 154 · see citing works

A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis

Meléndez‐Hevia, E., de Paz-Lugo, P., Cornish-Bowden, A. J., & Cárdenas, M. L. (2009) · Journal of Biosciences · doi:10.1007/s12038-009-0100-9 · Cited by 147 · see citing works

Ontogeny of the blood-brain barrier

Saunders, N. R. (1977) · Experimental Eye Research · doi:10.1016/s0014-4835(77)80046-8 · Cited by 138 · see citing works

Rapid Communication with a “P300” Matrix Speller Using Electrocorticographic Signals (ECoG)

Brunner, P., Ritaccio, A. L., Emrich, J. F., Bischof, H., & Schalk, G. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00005 · Cited by 133 · see citing works

Relation of potassium transport to oxidative metabolism in isolated brain capillaries

Goldstein, G. W. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012613 · Cited by 129 · see citing works

Brain Iron in the Rat: Extremely Slow Turnover in Normal Rats May Explain Long-Lasting Effects of Early Iron Deficiency

Dallman, P. R., & Spirito, R. A. (1977) · Journal of Nutrition · doi:10.1093/jn/107.6.1075 · Cited by 126 · see citing works

Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain

Coles, J. A., Myburgh, E., Brewer, J. M., & McMenamin, P. G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.002 · Cited by 123 · see citing works

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

Zloković, B. V., Lipovac, M. N., Begley, D. J., Davson, H., & Rakić, L. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb03431.x · Cited by 118 · see citing works

The functional morphology of the outflow systems of ocular and cerebrospinal fluids

Tripathi, R. C. (1977) · Experimental Eye Research · doi:10.1016/s0014-4835(77)80010-9 · Cited by 118 · see citing works

Peptidases, Peptides, and the Mammalian Blood–Brain Barrier

Brownlees, J., & Williams, C. H. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03223.x · Cited by 113 · see citing works

Recent advances in understanding brain capillary function

Goldstein, G. W., & Betz, A. L. (1983) · Annals of Neurology · doi:10.1002/ana.410140402 · Cited by 113 · see citing works

Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized cats

Antonaccio, M. J., & Taylor, D. G. (1977) · European Journal of Pharmacology · doi:10.1016/0014-2999(77)90345-4 · Cited by 107 · see citing works

Blood-brain barrier permeability to leucine-enkephalin,d-Alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine)

Zlokovic, B. V., Begley, D. J., & Chain-Eliash, D. G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90423-8 · Cited by 114 · see citing works

Fluids and barriers of the CNS: a historical viewpoint

Liddelow, S. A. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-2 · Cited by 99 · see citing works

Evidence for intracellular localization of alpha-fetoprotein in the developing rat brain

Benno, R. H., & Williams, T. H. (1978) · Brain Research · doi:10.1016/0006-8993(78)90189-0 · Cited by 96 · see citing works

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone

Zloković, B. V., Segal, M. B., Begley, D. J., Davson, H., & Rakić, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90963-1 · Cited by 92 · see citing works

Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter in newborn pigs.

Leffler, C. W., & Busija, D. W. (1985) · Circulation Research · doi:10.1161/01.res.57.5.689 · Cited by 92 · see citing works

Distribution of valproate across the interface between blood and cerebrospinal fluid

Frey, H. ‐., & Löscher, W. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90160-0 · Cited by 88 · see citing works

Transport ofl-lactate by cultured rat brain astrocytes

Tildón, J. T., McKenna, M. C., Stevenson, J., & Couto, R. (1993) · Neurochemical Research · doi:10.1007/bf01474682 · Cited by 85 · see citing works

The Anatomic Basis of the Blood-Brain Barrier

Brightman, M. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0701-3_3 · Cited by 84 · see citing works

The effect of aging on the mineral status of female mice

Morita, A., Kimura, M., & Itokawa, Y. (1994) · Biological Trace Element Research · doi:10.1007/bf02785387 · Cited by 81 · see citing works

The accumulation of Toxocara canis larvae in the brains of mice

Dunsmore, J. D., Thompson, R. C. A., & Bates, I. A. (1983) · International Journal for Parasitology · doi:10.1016/s0020-7519(83)80017-4 · Cited by 80 · see citing works

Blood‐brain barrier permeability and immobilization stress

Belova, T. I., & JONSSON, G. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb10594.x · Cited by 79 · see citing works

Immunohistochemical demonstration of serum proteins in human cerebral gliomas

Seitz, R. J., & Wechsler, W. (1987) · Acta Neuropathologica · doi:10.1007/bf00693780 · Cited by 77 · see citing works

Developmental changes in metabolism and transport properties of capillaries isolated from rat brain.

Betz, A. L., & Goldstein, G. W. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013633 · Cited by 77 · see citing works

Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid

Bannwarth, B., Netter, P., Pourel, J., Royer, R., & Gaucher, A. (1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90140-6 · Cited by 76 · see citing works

A study of intrathecal, cerebrospinal fluid-to-brain exchange

Aird, R. B. (1984) · Experimental Neurology · doi:10.1016/0014-4886(84)90192-4 · Cited by 75 · see citing works

Intracranial Pressure In Pigs with Surgically Induced Acute Liver Failure

Hanid, M. A., Mackenzie, R. L., Jenner, R. E., Chase, R. A., Mellon, P. J., Trewby, P., Janota, I., Davis, M., Silk, D. B. A., & Williams, R. L. (1979) · Gastroenterology · doi:10.1016/s0016-5085(79)80138-9 · Cited by 71 · see citing works

Drug targeting strategies into the brain for treating neurological diseases

Barnabas, W. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2018.10.015 · Cited by 70 · see citing works

Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening

Lee, E., Fomenko, A., & Lozano, A. M. (2019) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2018.0180 · Cited by 68 · see citing works

Blood--brain barrier sodium/potassium pump: modulation by central noradrenergic innervation.

Harik, S. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4067 · Cited by 69 · see citing works

Liposomes for drug delivery in stroke

Bruch, G. E., Fernandes, L. F., Bassi, B. L. T., Alves, M. T. R., Pereira, I. O., Frézard, F., & Massensini, A. R. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.015 · Cited by 67 · see citing works

The transport of sugars across the perfused choroid plexus of the sheep.

Deane, R., & Segal, M. B. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015674 · Cited by 66 · see citing works

Ventriculo–cisternal perfusion of twelve amino acids in the rabbit

Davson, H., Hollingsworth, J. R., Carey, M. B., & Fenstermacher, J. D. (1982) · Journal of Neurobiology · doi:10.1002/neu.480130402 · Cited by 65 · see citing works

Neuronal control of brain microvessel function

Kobayashi, H., Magnoni, M. S., Govoni, S. M., Izumi, F., Wada, A., & Trabucchi, M. (1985) · Cellular and Molecular Life Sciences · doi:10.1007/bf01966140 · Cited by 64 · see citing works

Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat

Haddad, G. G., & Jiang, C. L. (1993) · Brain Research · doi:10.1016/0006-8993(93)91067-3 · Cited by 60 · see citing works

Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain

Zhao, L., Tannenbaum, A., Bakker, E. N. T. P., & Benveniste, H. (2022) · Physiology · doi:10.1152/physiol.00015.2022 · Cited by 61 · see citing works

Low-Intensity Focused Ultrasound Technique in Glioblastoma Multiforme Treatment

Mungur, R., Zheng, J.-S., Wang, B., Chen, X., Zhan, R., & Tong, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.903059 · Cited by 57 · see citing works

The vasculature of experimental brain tumours

Deane, B. R., Greenwood, J., Lantos, P. L., & PRATT, O. E. (1984) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(84)90067-4 · Cited by 57 · see citing works

γ-Glutamyltranspeptidase induction mediated by glial foot process-to endothelium contact in co-culture

DeBault, L. E. (1981) · Brain Research · doi:10.1016/0006-8993(81)91238-5 · Cited by 56 · see citing works

An enzymatically stable peptide with activity in the central nervous system: Its penetration through the blood-CSF barrier

Hoffman, P. L., Walter, R., & Bulat, M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90664-3 · Cited by 54 · see citing works

The Neuronal Microenvironment: A Comparative View

Cserr, H. F., & Bundgaard, M. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27134.x · Cited by 50 · see citing works

Transport of GABA at the Blood‐CSF Interface

Löscher, W., & Frey, H. ‐. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb05350.x · Cited by 50 · see citing works

Central actions of β‐adrenoceptor blocking drugs in man

Patel, L., & Turner, P. (1981) · Medicinal Research Reviews · doi:10.1002/med.2610010405 · Cited by 50 · see citing works

Neonatal Immunization against Gonadotropin-Releasing Hormone (GnRH) Results in Diminished GnRH Secretion in Adulthood

Clarke, I. J., Brown, B. W., Tran, V. V., Scott, C., Fry, R. C., Millar, R. P., & Rao, A. (1998) · Endocrinology · doi:10.1210/en.139.4.2007 · Cited by 48 · see citing works

Arachidonate metabolism on the cerebral surface of newborn pigs

Leffler, C. W., & Busija, D. W. (1985) · Prostaglandins · doi:10.1016/0090-6980(85)90009-7 · Cited by 47 · see citing works

Evaluation of Routes of Administration of Interferon in Cancer: A Review and a Proposal

Bocci, V. A. (1984) · Cancer Drug Delivery · doi:10.1089/cdd.1984.1.337 · Cited by 46 · see citing works

Animal models for studying transport across the blood-brain barrier

Bonate, P. L. (1995) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)00081-q · Cited by 44 · see citing works

Hypothermia-induced reduction in the permeation of radiolabelled tracer substances across the blood-brain barrier

Krantis, A. (1983) · Acta Neuropathologica · doi:10.1007/bf00685348 · Cited by 43 · see citing works

WITHDRAWN: How to Increase and Decrease the Strength of Memory Traces: The Effects of Drugs and Hormones

Martinez, J. L., Schulteis, G., & Weinberger, S. B. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-474993-1.50009-2 · Cited by 43 · see citing works

Anatomy and physiology of blood-brain barrier

Gupta, S. N., Dhanda, S., & Sandhir, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00002-0 · Cited by 40 · see citing works

Evaluation of Gadopentetate Dimeglumine Magnetic Resonance Cisternography in an Animal Model

Jinkins, J. R., Williams, R. F., & Xiong, L. (1999) · Investigative Radiology · doi:10.1097/00004424-199902000-00009 · Cited by 39 · see citing works

Age-related changes in barrier function in mouse brain I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory

Ueno, M., Akiguchi, I., Yagi, H., Naiki, H., Fujibayashi, Y., Kimura, J., & Takeda, T. (1993) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(93)90035-g · Cited by 39 · see citing works

Blood-brain barrier permeability to dipeptides and their constituent amino acids

Zloković, B. V., Begley, D. J., & Chain, D. G. (1983) · Brain Research · doi:10.1016/0006-8993(83)91365-3 · Cited by 39 · see citing works

Levels of gamma-aminobutyric acid in cerebrospinal fluid and plasma during alcohol withdrawal

Adinoff, B. H., Kramer, G. L., & Petty, F. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02739-4 · Cited by 38 · see citing works

Anion Transport in the Nervous System

Kimelberg, H. K., & Bourke, R. S. (1982) · Springer eBooks · doi:10.1007/978-1-4757-0614-7_2 · Cited by 38 · see citing works

Blood-brain barrier delivery for lysosomal storage disorders with IgG-lysosomal enzyme fusion proteins

Pardridge, W. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114234 · Cited by 37 · see citing works

The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system

van Bree, J. B. M. M., Baljet, A. V., van Geyt, A., Boer, A. G. D., Danhof, M., & Breimer, D. D. (1989) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01061457 · Cited by 37 · see citing works

Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice

VORBRODT, A. W., Lossinsky, A. S., Wı́sniewski, H. M., Moretz, R. C., & Iwanowski, L. (1981) · Acta Neuropathologica · doi:10.1007/bf00688023 · Cited by 36 · see citing works

Availability of liposome content to the nervous system. Liposomes and the blood-brain barrier

̈kés, Z. ́. A. T., ́teri, A. ́. K. ́. S. P., & Todd, J. A. (1980) · Brain Research · doi:10.1016/0006-8993(80)90578-8 · Cited by 35 · see citing works

Direct administration of methotrexate into the central nervous system of primates

Kimelberg, H. K., Kung, D. K., Watson, R. E., Reiss, F. L., Biddlecome, S. M., & BOURKE, R. S. (1978) · Journal of neurosurgery · doi:10.3171/jns.1978.48.6.0883 · Cited by 35 · see citing works

The Structure of the Nervous System

Schmidt, R. F. (1978) · Springer eBooks · doi:10.1007/978-3-662-01154-6_1 · Cited by 33 · see citing works

[29] Targeting of drugs to the brain

Bodor, N. S. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)12031-8 · Cited by 33 · see citing works

Peripheral modulation of learning and memory: enkephalins as a model system

Schulteis, G., & Martinez, J. L. (1992) · Psychopharmacology · doi:10.1007/bf02245883 · Cited by 33 · see citing works

Identifying the attended speaker using electrocorticographic (ECoG) signals

Dijkstra, K., Brunner, P., Gunduz, A., Coon, W. G., Ritaccio, A. L., Farquhar, J. D. R., & Schalk, G. (2015) · Brain-Computer Interfaces · doi:10.1080/2326263x.2015.1063363 · Cited by 31 · see citing works

Selective drug delivery approaches to lesioned brain through blood brain barrier disruption

Al-Ahmady, Z. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1444601 · Cited by 29 · see citing works

Does ethanol damage the blood-brain barrier?

Phillips, S. C. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90043-5 · Cited by 32 · see citing works

Primitive forms of potassium homeostasis: Observations on crustacean central nervous system with implications for vertebrate brain

Abbott, N. J., Pichon, Y., & Lane, N. J. (1977) · Experimental Eye Research · doi:10.1016/s0014-4835(77)80023-7 · Cited by 31 · see citing works

The neurovascular unit in healthy and injured spinal cord

Zhou, R., Li, J., Wang, R., Chen, Z., & Zhou, F. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231172008 · Cited by 30 · see citing works

Measurement of blood‐brain barrier permeation in rats during exposure to 2450‐MHz microwaves

Ward, T. R., Elder, J. A., Long, M. D., & Svendsgaard, D. J. (1982) · Bioelectromagnetics · doi:10.1002/bem.2250030309 · Cited by 30 · see citing works

In vitro reconstituted blood-brain barrier

Dehouck, M., Méresse, S., Dehouck, B., Fruchart, J., & Cecchelli, R. (1992) · Journal of Controlled Release · doi:10.1016/0168-3659(92)90010-o · Cited by 30 · see citing works

Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism

Zloković, B. V., Segal, M. B., Davson, H., & Mitrovic, D. M. (1988) · Regulatory Peptides · doi:10.1016/0167-0115(88)90055-9 · Cited by 30 · see citing works

New concept of cerebrospinal fluid dynamics in cerebral venous sinus thrombosis

Park, J. H., & Yoon, S. H. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.03.036 · Cited by 29 · see citing works

Blood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology

Badaut, J., Ghersi‐Egea, J., Thorne, R. G., & Konsman, J. P. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00478-5 · Cited by 30 · see citing works

Weakening of the blood-brain barrier by alcohol-related stresses in the rat

Phillips, S. C., & Cragg, B. G. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90187-3 · Cited by 28 · see citing works

Central effect of taurine and its analogues on fever caused by intravenous leukocytic pyrogen in the rabbit.

Lipton, J. M., & Ticknor, C. B. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012675 · Cited by 28 · see citing works

Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier

Zloković, B. V., Segal, M. B., Davson, H., & Jankov, R. (1988) · Peptides · doi:10.1016/0196-9781(88)90160-x · Cited by 28 · see citing works

Radiation and brain calcium: A review and critique

Myers, R. D., & Ross, D. H. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90021-x · Cited by 27 · see citing works

Improved Delivery Through Biological Membranes XIX: Novel Redox Carriers for Brain-Specific Chemical Delivery Systems

Bodor, N. S., & Abdelalim, A. M. (1985) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600740304 · Cited by 27 · see citing works

Distribution, survival and biological effects in mice of a behaviorally active, enzymatically stable peptide: Pharmacokinetics of cyclo(Leu-Gly) and puromycin-induced amnesia

Rainbow, T. C., Flexner, J. B., Flexner, L. B., Hoffman, P. L., & Walter, R. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90334-4 · Cited by 27 · see citing works

Chemistry of the Gastrointestinal Hormones and Hormone-like Peptides and a Sketch of Their Physiology and Pharmacology

Mutt, V. (1982) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61138-3 · Cited by 27 · see citing works

Blood‐Brain Barrier Designated Lecture

(2002) · The Journal of Physiology · doi:10.1111/j.1469-7793.2002.tb00693.x

Blood‐Brain Barrier

(1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.tb00115.x

Blood-brain barrier in physiology and medicine

O’Brien, M. D. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90141-1 · Cited by 353 · see citing works

The blood—brain barrier and the extracellular space of brain

Davson, H., & Spaziani, E. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006330 · Cited by 156 · see citing works

The Blood-Brain Barrier

Dobbing, J. (1961) · Physiological Reviews · doi:10.1152/physrev.1961.41.1.130 · Cited by 259 · see citing works