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Chloride current induced by injection of calcium into Xenopus oocytes.
Open accessAbstract
Membrane currents of Xenopus oocytes were studied with the membrane under voltage clamp. Intracellular injection of the calcium‐chelating agent EGTA reduced, or abolished, the transient outward chloride current normally activated by membrane depolarization. Intracellular injection of calcium ions evoked large membrane currents, which inverted direction close to the chloride equilibrium potential. Injections of strontium, or barium, were less effective than calcium, while magnesium was ineffective. Large chloride currents could be evoked by calcium injections in oocytes which showed only small or no transient outward currents. The current activated by calcium injection increased with increasing depolarization up to high (ca. +60 mV) positive potentials, even though the transient outward current was suppressed by strong depolarization. The results indicate that the transient outward current depends upon entry of calcium through voltage‐gated calcium ion channels and show that the oocyte membrane contains numerous chloride channels which are activated by intracellular calcium. Only a few of these chloride channels are activated by depolarization.
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Cited by
Ca2 + Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition
Hollmann, M., Hartley, M., & Heinemann, S. (1991) · Science · doi:10.1126/science.1709304 · Cited by 1,456
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors
Vernino, S., Amador, M., Luetje, C. W., Patrick, J., & Dani, J. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90114-s · Cited by 469
Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities
Eiselé, J.-L., Bertrand, S., Galzi, J.-L., Devillers-Thiéry, A., Changeux, J.-P., & Bertrand, D. (1993) · Nature · doi:10.1038/366479a0 · Cited by 405
Nakai, J., Imagawa, T., Hakamata, Y., Shigekawa, M., Takeshima, H., & Numa, S. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80399-4 · Cited by 360
Intracellular calcium ions decrease the affinity of the GABA receptor
Inoue, M., Oomura, Y., Yakushiji, T., & Akaike, N. (1986) · Nature · doi:10.1038/324156a0 · Cited by 270
Metadata
- Authors
- Miledi, R., & Parker, I.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1984-12
- Volume
- 357
- Issue
- 1
- Pages
- 173-183
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1972833869
- Cited by
- 394
- References
- 0
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
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